Search Results - "Yim, H. C. H."

Cu‐Catalyzed Desulfonylative Amination of Benzhydryl Sulfones by Nambo, Masakazu, Tahara, Yasuyo, Yim, Jacky C.‐H., Crudden, Cathleen M.

“…A new method for the synthesis of benzhydryl amines from the reaction of readily available sulfone derivatives with amines is described. The Cu‐catalyzed…”
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Pd-Catalyzed Desulfonative Cross-Coupling of Benzylic Sulfone Derivatives with 1,3-Oxazoles by Yim, Jacky C.-H, Nambo, Masakazu, Crudden, Cathleen M

“…The Pd-catalyzed desulfonative cross-coupling reaction of benzylic sulfone derivatives with 1,3-oxazoles via a deprotonative pathway has been developed. Broad…”
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Efficient Anti-Markovnikov-Selective Catalysts for Intermolecular Alkyne Hydroamination: Recent Advances and Synthetic Applications by Yim, Jacky C. -H., Schafer, Laurel L.

“…Transition‐metal‐catalyzed hydroamination of alkynes with primary amines is a reliable tool for the synthesis of imines and enamines. Intramolecular…”
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SARS-CoV-2 and male infertility: from short- to long-term impacts by Dai, P., Qiao, F., Chen, Y., Chan, D. Y. L., Yim, H. C. H., Fok, K. L., Chen, H.

“…Purpose The coronavirus 2019 (COVID-19) pandemic—caused by a new type of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)—has posed severe impacts…”
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Visible-light-induced direct C-H alkylation of polycyclic aromatic hydrocarbons with alkylsulfones by Ohtsuka, Motoo, Ghosh, Koushik, Yim, Jacky C.-H, Sotome, Hikaru, Okamoto, Tsubasa, Suda, Kayo, Kobori, Yasuhiro, Yokogawa, Daisuke, Miyasaka, Hiroshi, Crudden, Cathleen M, Nambo, Masakazu

“…Polycyclic aromatic hydrocarbons (PAHs) are fragments of graphene that have attracted considerable attention as a new class of carbon-based materials. The…”
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Tantalum Catalyzed Hydroaminoalkylation for the Synthesis of α- and β‑Substituted N‑Heterocycles by Payne, Philippa R, Garcia, Pierre, Eisenberger, Patrick, Yim, Jacky C.-H, Schafer, Laurel L

“…Unprotected secondary amines are directly alkylated by C–H functionalization adjacent to nitrogen, thereby opening new routes toward the synthesis of α- and…”
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Bis(amidate)bis(amido) Titanium Complex: A Regioselective Intermolecular Alkyne Hydroamination Catalyst by Yim, Jacky C.-H, Bexrud, Jason A, Ayinla, Rashidat O, Leitch, David C, Schafer, Laurel L

“…An efficient and selective bis­(amidate)­bis­(amido) titanium precatalyst for the anti-Markovnikov hydroamination of alkynes is reported. Hydroamination of…”
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The kinase activity of PKR represses inflammasome activity by Yim, Howard CH, Wang, Die, Yu, Liang, White, Christine L, Faber, Pieter W, Williams, Bryan RG, Sadler, Anthony J

“…The protein kinase R （PKR） functions in the antiviral response by controlling protein translation and inflamma- tory cell signaling pathways. We generated a…”
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Integrin-Linked Kinase Expression in Myeloid Cells Promotes Inflammatory Signaling during Experimental Colitis by Ahmed, Afsar U, Yim, Howard C H, Alorro, Mariah, Ernst, Matthias, Williams, Bryan R G

“…The pathology of inflammatory bowel diseases is driven by the inflammatory signaling pathways associated with mucosal epithelial damage. Myeloid cells are…”
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BTB-ZF transcriptional regulator PLZF modifies chromatin to restrain inflammatory signaling programs by Sadler, Anthony J., Rossello, Fernando J., Yu, Liang, Deane, James A., Yuan, Xiangliang, Wang, Die, Irving, Aaron T., Kaparakis-Liaskos, Maria, Gantier, Michael P., Ying, Hangjie, Yim, Howard C. H., Hartland, Elizabeth L., Notini, Amanda J., de Boer, Suzan, White, Stefan J., Mansell, Ashley, Liu, Jun-Ping, Watkins, D. Neil, Gerondakis, Steve, Williams, Bryan R. G., Xu, Dakang

“…Inflammation is critical for host defense, but without appropriate control, it can cause chronic disease or even provoke fatal responses. Here we identify a…”
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Modular synthesis of α-fluorinated arylmethanes via desulfonylative cross-coupling by Nambo, Masakazu, Yim, Jacky C.-H., Freitas, Luiza B. O., Tahara, Yasuyo, Ariki, Zachary T., Maekawa, Yuuki, Yokogawa, Daisuke, Crudden, Cathleen M.

“…α-Fluoromethylarenes are common substructures in pharmaceuticals and agrochemicals, with the introduction of fluorine often resulting in improved biological…”
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Synthesis and preclinical testing of a selective beta-subtype agonist of thyroid hormone receptor ZTA-261 by Nambo, Masakazu, Nishiwaki-Ohkawa, Taeko, Ito, Akihiro, Ariki, Zachary T., Ito, Yuka, Kato, Yuuki, Yar, Muhammad, Yim, Jacky C. -H., Kim, Emily, Sharkey, Elizabeth, Kano, Keiko, Mishiro-Sato, Emi, Okimura, Kosuke, Maruyama, Michiyo, Ota, Wataru, Furukawa, Yuko, Nakayama, Tomoya, Kobayashi, Misato, Horio, Fumihiko, Sato, Ayato, Crudden, Cathleen M., Yoshimura, Takashi

“…Background Thyroid hormones (TH) regulate the basal metabolic rate through their receptors THRα and THRβ. TH activates lipid metabolism via THRβ, however, an…”
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Copper-catalyzed Desulfonylative Cross-coupling of Benzhydryl Sulfones with Azoles by Yim, Jacky C.-H., Nambo, Masakazu, Tahara, Yasuyo, Crudden, Cathleen M.

“…The synthesis of azole-containing triarylmethanes via the Cu-catalyzed desulfonylative reaction of benzhydryl sulfone derivatives with azoles is described…”
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Facile Access to Tuneable Schwartz's Reagents: Oxidative Addition Products from the Reaction of Amide NH Bonds with Reduced Zirconocene Complexes by Haehnel, Martin, Yim, Jacky C.-H., Schafer, Laurel L., Rosenthal, Uwe

“…On the tracks of Schwartz's reagent: Two zirconocene hydrido amidate complexes are synthesized by formal oxidative addition of amide NH bonds to reduced…”
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The CYP3A418 Genotype in the Cytochrome P450 3A4 Gene, a Rapid Metabolizer of Sex Steroids, Is Associated With Low Bone Mineral Density by Kang, YS, Park, SY, Yim, CH, Kwak, HS, Gajendrarao, P, Krishnamoorthy, N, Yun, S‐C, Lee, KW, Han, KO

“…Osteoporosis is influenced by genetic factors. The interindividual variability in the activity of CYP3A, the metabolic enzyme of sex hormones, may result from…”
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Synthesis of quaternary centres by single electron reduction and alkylation of alkylsulfones by Nambo, Masakazu, Tahara, Yasuyo, Yim, Jacky C.-H, Yokogawa, Daisuke, Crudden, Cathleen M

“…A new method for the generation of tertiary radicals through single electron reduction of alkylsulfones promoted by Zn and 1,10-phenanthroline has been…”
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Four-Membered Heterometallacyclic d0 and d1 Complexes of Group 4 Metallocenes with Amidato Ligands by Haehnel, Martin, Priebe, Jacqueline B., Yim, Jacky C.-H., Spannenberg, Anke, Brückner, Angelika, Schafer, Laurel L., Rosenthal, Uwe

“…A study of the coordination chemistry of different amidato ligands [(R)NC(Ph)O] (R=Ph, 2,6‐diisopropylphenyl (Dipp)) at Group 4 metallocenes is presented. The…”
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role for c-Myc in regulating anti-mycobacterial responses by Yim, Howard C. H, Li, James C. B, Pong, John C. H, Lau, Allan S. Y

“…c-Myc (Myc) is a well known transcription factor that regulates many essential cellular processes; however, its role in modulating immunity is not known. Here,…”
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Development of Versatile Sulfone Electrophiles for Suzuki–Miyaura Cross-Coupling Reactions by Nambo, Masakazu, Keske, Eric C, Rygus, Jason P. G, Yim, Jacky C.-H, Crudden, Cathleen M

“…The development of fluorinated sulfone derivatives as versatile electrophiles for Suzuki–Miyaura cross-coupling reactions is described. Introducing…”
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Hydration of nitriles: an examination in terms of No Barrier Theory by Guthrie, J. Peter, Yim, Jacky C.-H., Wang, Qiang

“…Nitriles pose an interesting problem to the explanatory powers of organic chemistry because, despite the favorable overall thermodynamics of hydrolysis to the…”
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