Serum oxidized low density lipoprotein levels in preeclamptic and normotensive pregnants

BACKGROUNDS/AIM: The aim of the study was to determine serum lipids and oxidized low density lipoprotein (ox-LDL) levels in preeclamptic pregnants and compare with those of normotensives. Ox-LDL levels were determined by enzyme linked immunosorbent assay (ELISA); total cholesterol, hight density lip...

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Published in:	Clinical and experimental obstetrics & gynecology Vol. 42; no. 6; pp. 746 - 748
Main Authors:	Kozan, A, Yildirmak, S Turkmen, Mihmanli, V, Ayabakan, H, Cicek, Y G, Kalaslioglu, V, Doean, S, Cebeci, H Cerci
Format:	Journal Article
Language:	English
Published:	Canada 01-01-2015
Subjects:	Adult Blood Pressure Case-Control Studies Cholesterol - blood Cholesterol, LDL - blood Enzyme-Linked Immunosorbent Assay Female Humans Lipoproteins - blood Lipoproteins, LDL - blood Pre-Eclampsia - blood Pregnancy - blood Triglycerides - blood Turkey Turkey
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Summary:	BACKGROUNDS/AIM: The aim of the study was to determine serum lipids and oxidized low density lipoprotein (ox-LDL) levels in preeclamptic pregnants and compare with those of normotensives. Ox-LDL levels were determined by enzyme linked immunosorbent assay (ELISA); total cholesterol, hight density lipoprotein (HDL)-cholesterol and triglyceride levels were measured by enzymatic colorimetric assay in 26 normotensive and 27 preeclamptic pregnants. LDL and very low density lipoprotein (VLDL) cholesterol was calculated by Friedwald formula. Serum levels of Ox-LDL (U/L), total-cholesterol (mg/dL), HDL-cholesterol (mg/dL), LDL-cholesterol (mg/dL), triglyceride (mg/dL), and VLDL-cholesterol (mg/dL) in normotensive and preeclamptic pregnants were found as 130±60 and 133±69; 248±49 and 248±81; 67±14 and 61±16; 147±61 and 135±59; 207±76 and 256±87; 41±15 and 50±17, respectively. Mean values of Ox-LDL and other lipid parameters were higher than the upper limits of their reference ranges in both of groups. However no significant differences were found in Ox-LDL, total, HDL and LDL-cholesterol levels between two groups. However, the levels of triglyceride and VLDL-cholesterol were significantly higher in preeclampsia group. The present results suggest that the levels of serum Ox-LDL and other lipid parameters rise as a result of pregnancy rather than as a result of preeclampsia.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Undefined-2
ISSN:	0390-6663
DOI:	10.12891/ceog1974.2015