Peripheral nesfatin-1 reduces basal brain activity but has limited effect on epilepsy-like conditions

In this study, we investigated the effects of peripheral nesfatin-1 on basal brain activity and 4-aminopyridine (4-AP)-induced epileptiform activity, and its relationship with the electrocorticogram (ECoG) power spectrum and EEG bands. Forty-nine male Wistar rats were divided into seven groups: cont...

Full description

Saved in:

Bibliographic Details
Published in:	General physiology and biophysics Vol. 43; no. 5; p. 457
Main Authors:	Faruk Kalkan, Ömer, Aktaş, Osman, Şahin, Zafer, Aydin Abidin, Selcen, Yildirim, Abdulhamit, Faruk Özyaşar, Ali, Uzun, İbrahim, Abidin, İsmail
Format:	Journal Article
Language:	English
Published:	Slovakia 01-09-2024
Subjects:	Animals Anticonvulsants - administration & dosage Anticonvulsants - pharmacology Brain - drug effects Brain - metabolism Calcium-Binding Proteins - administration & dosage Calcium-Binding Proteins - metabolism DNA-Binding Proteins - administration & dosage DNA-Binding Proteins - metabolism Electroencephalography Epilepsy - blood Epilepsy - chemically induced Epilepsy - physiopathology Male Nerve Tissue Proteins - administration & dosage Nerve Tissue Proteins - metabolism Nerve Tissue Proteins - pharmacology Nucleobindins Rats Rats, Wistar Treatment Outcome
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	In this study, we investigated the effects of peripheral nesfatin-1 on basal brain activity and 4-aminopyridine (4-AP)-induced epileptiform activity, and its relationship with the electrocorticogram (ECoG) power spectrum and EEG bands. Forty-nine male Wistar rats were divided into seven groups: control sham, 4-AP (2.5 mg/kg i.p.), Nesfatin-1 (1, 2, and 4 μg/kg i.p.), Nesfatin-1 (2 μg/kg) post-treatment, and Nesfatin-1 (2 μg/kg) pre-treatment. Recordings were conducted for 70 min under ketamine/xylazine (90/10 mg/kg) anesthesia. In the post-treatment group, nesfatin-1 was injected 20 min after 4-AP induction. In the pre-treatment groups, nesfatin-1 was administered following basal recordings and before 4-AP injection. 4-AP induced epileptiform activity in all animals, peaking at 30 min. Nesfatin-1 (2 μg/kg) reduced basal brain activity (p < 0.05) and decreased alpha, delta, and theta bands in ECoG. Post-treatment of nesfatin-1 did not affect 4-AP-induced activity (p > 0.05) but increased gamma band activity (p > 0.05). Pre-treatment of nesfatin-1 reduced epileptiform activity between 50 and 60 min (p < 0.05), decreased delta bands, and increased gamma bands (p > 0.05). We conclude that peripheral nesfatin-1 modulates normal brain activity but has limited effects on abnormal discharges.
ISSN:	0231-5882
DOI:	10.4149/gpb_2024026