The Association of Thyroid Hormone Changes with Inflammatory Status and Prognosis in COVID-19

The Association of Thyroid Hormone Changes with Inflammatory Status and Prognosis in COVID-19

Background. COVID-19 infection may have multiorgan effects in addition to effects on the lungs and immune system. Recently, studies have found thyroid function abnormalities in COVID-19 cases which were interpreted as euthyroid sick syndrome (ESS) or destructive thyroiditis. Therefore, in this study...

Full description

Saved in:
Bibliographic Details
Published in:International journal of endocrinology Vol. 2021; pp. 2395212 - 11
Main Authors: Dincer Yazan, Ceyda, Ilgin, Can, Elbasan, Onur, Apaydin, Tugce, Dashdamirova, Saida, Yigit, Tayfun, Sili, Uluhan, Karahasan Yagci, Aysegul, Sirikci, Onder, Haklar, Goncagul, Gozu, Hulya
Format: Journal Article
Language:English
Published: Egypt Hindawi 2021
John Wiley & Sons, Inc
Hindawi Limited
Subjects:
Antibodies
Autoimmunity
Cardiovascular disease
Cluster analysis
Coronaviruses
COVID-19
Creatinine
Dehydrogenases
Endocrinology
Health aspects
Hormones
Hyperthyroidism
Hypothyroidism
Immunoassay
Intensive care
Lymphocytes
Medical records
Mortality
Patients
Prognosis
Thyroid diseases
Thyroid gland
Thyrotropin
Thyroxine
Tumor necrosis factor-TNF
Ventilators
Viral antibodies
United States > US
Germany
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background. COVID-19 infection may have multiorgan effects in addition to effects on the lungs and immune system. Recently, studies have found thyroid function abnormalities in COVID-19 cases which were interpreted as euthyroid sick syndrome (ESS) or destructive thyroiditis. Therefore, in this study, we aimed to evaluate the thyroid function status and thyroid autoimmunity in COVID-19 patients. Material and Method. 205 patients were included. The medical history and laboratory parameters at admission were collected from medical records. Serum thyroid-stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3), thyroid peroxidase antibody, and thyroglobulin antibody were measured, and patients were classified according to thyroid function status. Results. 34.1% of the patients were euthyroid. Length of hospitalization (p<0.001), rate of oxygen demand (p<0.001), and intensive care unit (ICU) admission (p=0.022) were lower, and none of the euthyroid patients died. 108 (52.6%) patients were classified to have ESS, 57 were classified as mild, and 51 were moderate. The inflammatory parameters were higher in patients with moderate ESS. In cluster analysis, a high-risk group with a lower median FT3 value (median = 2.34 ng/L; IQR = 0.86), a higher median FT4 value (median = 1.04 ng/dL; IQR = 0.33), and a lower median TSH value (median = 0.62 mIU/L; IQR = 0.59) included 8 of 9 died patients and 25 of the 31 patients that were admitted to ICU. Discussion. Length of hospitalization, oxygen demand, ICU admission, and mortality were lower in euthyroid patients. Moreover, none of the euthyroid patients died. In conclusion, evaluation of thyroid function tests during COVID-19 infection may give information about the prognosis of disease.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Academic Editor: Per Hellström
ISSN:1687-8337
1687-8345
DOI:10.1155/2021/2395212