Search Results - "Yiew, Nicole K H"

Sex-Dependent Role of Adipose Tissue HDAC9 in Diet-Induced Obesity and Metabolic Dysfunction by Goo, Brandee, Ahmadieh, Samah, Zarzour, Abdalrahman, Yiew, Nicole K H, Kim, David, Shi, Hong, Greenway, Jacob, Cave, Stephen, Nguyen, Jenny, Aribindi, Swetha, Wendolowski, Mark, Veerapaneni, Praneet, Ogbi, Mourad, Chen, Weiqin, Lei, Yun, Lu, Xin-Yun, Kim, Ha Won, Weintraub, Neal L

“…Obesity is a major risk factor for both metabolic and cardiovascular disease. We reported that, in obese male mice, histone deacetylase 9 (HDAC9) is…”
Get full text

An epithelial cell-derived metabolite tunes immunoglobulin A secretion by gut-resident plasma cells by Ceglia, Simona, Berthelette, Alyssa, Howley, Kelsey, Li, Yun, Mortzfeld, Benedikt, Bhattarai, Shakti K., Yiew, Nicole K. H., Xu, Ying, Brink, Robert, Cyster, Jason G., Hooper, Lora V., Randolph, Gwendalyn J., Bucci, Vanni, Reboldi, Andrea

“…Immunoglobulin A (IgA) secretion by plasma cells, terminally differentiated B cells residing in the intestinal lamina propria, assures microbiome homeostasis…”
Get full text

Role of Arginase 2 in Systemic Metabolic Activity and Adipose Tissue Fatty Acid Metabolism in Diet-Induced Obese Mice by Atawia, Reem T, Toque, Haroldo A, Meghil, Mohamed M, Benson, Tyler W, Yiew, Nicole K H, Cutler, Christopher W, Weintraub, Neal L, Caldwell, Ruth B, Caldwell, Robert W

“…Visceral adipose tissue (VAT) inflammation and metabolic dysregulation are key components of obesity-induced metabolic disease. Upregulated arginase, a…”
Get full text

The mitochondrial pyruvate carrier at the crossroads of intermediary metabolism by Yiew, Nicole K H, Finck, Brian N

“…Pyruvate metabolism, a central nexus of carbon homeostasis, is an evolutionarily conserved process and aberrant pyruvate metabolism is associated with and…”
Get more information

Enhancer of zeste homolog 2 (EZH2) regulates adipocyte lipid metabolism independent of adipogenic differentiation: Role of apolipoprotein E by Yiew, Nicole K.H., Greenway, Charlotte, Zarzour, Abdalrahman, Ahmadieh, Samah, Goo, Brandee, Kim, David, Benson, Tyler W., Ogbi, Mourad, Tang, Yao Liang, Chen, Weiqin, Stepp, David, Patel, Vijay, Hilton, Renee, Lu, Xin-Yun, Hui, David Y., Kim, Ha Won, Weintraub, Neal L.

“…Enhancer of zeste homolog 2 (EZH2), an epigenetic regulator that plays a key role in cell differentiation and oncogenesis, was reported to promote adipogenic…”
Get full text

Silencing alanine transaminase 2 in diabetic liver attenuates hyperglycemia by reducing gluconeogenesis from amino acids by Martino, Michael R., Gutiérrez-Aguilar, Manuel, Yiew, Nicole K.H., Lutkewitte, Andrew J., Singer, Jason M., McCommis, Kyle S., Ferguson, Daniel, Liss, Kim H.H., Yoshino, Jun, Renkemeyer, M. Katie, Smith, Gordon I., Cho, Kevin, Fletcher, Justin A., Klein, Samuel, Patti, Gary J., Burgess, Shawn C., Finck, Brian N.

“…Hepatic gluconeogenesis from amino acids contributes significantly to diabetic hyperglycemia, but the molecular mechanisms involved are incompletely…”
Get full text

Impact of housing temperature on adipose tissue HDAC9 expression and adipogenic differentiation in high fat‐fed mice by Ahmadieh, Samah, Goo, Brandee, Zarzour, Abdalrahman, Kim, David, Shi, Hong, Veerapaneni, Praneet, Chouhaita, Ronnie, Yiew, Nicole K. H., Dominguez Gonzalez, Carla, Chakravartty, Akash, Pennoyer, James, Hassan, Nazeera, Benson, Tyler W., Ogbi, Mourad, Fulton, David J., Lee, Richard, Rice, Robert D., Hilton, Lisa R., Lei, Yun, Lu, Xin‐Yun, Chen, Weiqin, Kim, Ha Won, Weintraub, Neal L.

“…Objective Impaired adipogenic differentiation exacerbates metabolic disease in obesity. This study reported that high‐fat diet (HFD)‐fed mice housed at…”
Get full text

Mitochondrial pyruvate carrier inhibition initiates metabolic crosstalk to stimulate branched chain amino acid catabolism by Ferguson, Daniel, Eichler, Sophie J., Yiew, Nicole K.H., Colca, Jerry R., Cho, Kevin, Patti, Gary J., Shew, Trevor M., Lutkewitte, Andrew J., Mukherjee, Sandip, McCommis, Kyle S., Niemi, Natalie M., Finck, Brian N.

“…The mitochondrial pyruvate carrier (MPC) has emerged as a therapeutic target for treating insulin resistance, type 2 diabetes, and nonalcoholic steatohepatitis…”
Get full text

A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity by Yiew, Nicole K.H., Chatterjee, Tapan K., Tang, Yao Liang, Pellenberg, Rod, Stansfield, Brian K., Bagi, Zsolt, Fulton, David J., Stepp, David W., Chen, Weiqin, Patel, Vijay, Kamath, Vinayak M., Litwin, Sheldon E., Hui, David Y., Rudich, Steven M., Kim, Ha Won, Weintraub, Neal L.

“…Impaired adipogenic differentiation during diet-induced obesity (DIO) promotes adipocyte hypertrophy and inflammation, thereby contributing to metabolic…”
Get full text

Silencing alanine transaminase 2 in diabetic liver attenuates hyperglycemia by reducing gluconeogenesis from amino acids by Martino, Michael R., Gutiérrez-Aguilar, Manuel, Yiew, Nicole K.H., Lutkewitte, Andrew J., Singer, Jason M., McCommis, Kyle S., Ferguson, Daniel, Liss, Kim H.H., Yoshino, Jun, Renkemeyer, M. Katie, Smith, Gordon I., Cho, Kevin, Fletcher, Justin A., Klein, Samuel, Patti, Gary J., Burgess, Shawn C., Finck, Brian N.

Get full text

Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult by Yiew, Nicole K.H., Vazquez, Joel H., Martino, Michael R., Kennon-McGill, Stefanie, Price, Jake R., Allard, Felicia D., Yee, Eric U., Layman, Alexander J., James, Laura P., McCommis, Kyle S., Finck, Brian N., McGill, Mitchell R.

“…Mitochondrial pyruvate is a critical intermediary metabolite in gluconeogenesis, lipogenesis, and NADH production. As a result, the mitochondrial pyruvate…”
Get full text

Deletion of the Duffy antigen receptor for chemokines (DARC) promotes insulin resistance and adipose tissue inflammation during high fat feeding by Benson, Tyler W., Weintraub, Daniel S., Crowe, Matthew, Yiew, Nicole K.H., Popoola, Orishebawo, Pillai, Ajay, Joseph, Joel, Archer, Krystal, Greenway, Charlotte, Chatterjee, Tapan K., Mintz, James, Stepp, David W., Stansfield, Brian K., Chen, Weiqin, Brittain, Julia, Bogdanov, Vladimir Y., Gao, Yan, Wilson, James G., Tang, Yaoliang, Kim, Ha Won, Weintraub, Neal L.

“…Inflammation in adipose tissues in obesity promotes insulin resistance and metabolic disease. The Duffy antigen receptor for chemokines (DARC) is a promiscuous…”
Get full text

Effects of hepatic mitochondrial pyruvate carrier deficiency on de novo lipogenesis and gluconeogenesis in mice by Yiew, Nicole K.H., Deja, Stanislaw, Ferguson, Daniel, Cho, Kevin, Jarasvaraparn, Chaowapong, Jacome-Sosa, Miriam, Lutkewitte, Andrew J., Mukherjee, Sandip, Fu, Xiaorong, Singer, Jason M., Patti, Gary J., Burgess, Shawn C., Finck, Brian N.

“…The liver coordinates the systemic response to nutrient deprivation and availability by producing glucose from gluconeogenesis during fasting and synthesizing…”
Get full text

Epithelial-derived oxysterol production tunes intestinal IgA secretion against commensals and enteric pathogen in tissue by Ceglia, Simona, Berthelette, Alyssa, Howley, Kelsey, Li, Yun, Yiew, Nicole K. H., Xu, Ying, Brink, Robert Adrian, Cyster, Jason G., Hooper, Lora V., Randolph, Gwendalyn J., Reboldi, Andrea

“…Abstract Immunoglobulin A (IgA) secretion by plasma cells (PCs), terminally differentiated B cells residing in the intestinal lamina propria, assures…”
Get full text

Obesity‐induced metabolic and vascular dysregulation: Implication of arginase by Atawia, Reem T., Toque, Haroldo A., Chen, Jijun, Meghil, Mohamed M., Benson, Tyler W., Yiew, Nicole K. H., Bunch, Katharine L., Cutler, Christopher W., Weintraub, Neal L., Caldwell, Ruth B., Caldwell, Robert W.

“…Obesity epidemic continues to rise worldwide, currently affecting more than 2 billion people. Visceral (central) obesity is of great importance as it…”
Get full text

213-LB: Mechanisms of Metabolic Cross Talk between Mitochondrial Pyruvate Carrier Inhibition and Branched-Chain Amino Acid Catabolism in Hepatocytes by FERGUSON, DANIEL, YIEW, NICOLE K.H., MCCOMMIS, KYLE S., COLCA, JERRY R., FINCK, BRIAN N.

“…The mitochondrial pyruvate carrier (MPC) has emerged as a therapeutic target for treating insulin resistance, type 2 diabetes, and nonalcoholic steatohepatitis…”
Get full text