Search Results - "Yi, Kaikai"

Dual‐Locking Nanoparticles Disrupt the PD‐1/PD‐L1 Pathway for Efficient Cancer Immunotherapy by Zhang, Zhanzhan, Wang, Qixue, Liu, Qi, Zheng, Yadan, Zheng, Chunxiong, Yi, Kaikai, Zhao, Yu, Gu, Yu, Wang, Ying, Wang, Chun, Zhao, Xinzhi, Shi, Linqi, Kang, Chunsheng, Liu, Yang

“…The clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR‐associated (Cas) enzyme, Cas13a, holds great promise in cancer treatment due to…”
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EGFR/c-myc axis regulates TGFβ/Hippo/Notch pathway via epigenetic silencing miR-524 in gliomas by Zhao, Kai, Wang, Qixue, Wang, Yunfei, Huang, Kai, Yang, Chao, Li, Yansheng, Yi, Kaikai, Kang, Chunsheng

“…The epidermal growth factor receptor (EGFR) frequently undergoes high-level genomic amplification and variant III (vIII) deletion in adult glioblastoma…”
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Engineering blood exosomes for tumor-targeting efficient gene/chemo combination therapy by Zhan, Qi, Yi, Kaikai, Qi, Hongzhao, Li, Sidi, Li, Xueping, Wang, Qixue, Wang, Yunfei, Liu, Chaoyong, Qiu, Mingzhe, Yuan, Xubo, Zhao, Jin, Hou, Xin, Kang, Chunsheng

“…Developing an effective nanoplatform to realize 'multi-in-one' is essential to broaden the therapeutic potential of combination therapy. Exosomes are ideal…”
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Phosphatidylcholine‐Engineered Exosomes for Enhanced Tumor Cell Uptake and Intracellular Antitumor Drug Delivery by Zhan, Qi, Yi, Kaikai, Li, Xueping, Cui, Xiaoteng, Yang, Eryan, Chen, Ning, Yuan, Xubo, Zhao, Jin, Hou, Xin, Kang, Chunsheng

“…Exosomes derived from non‐tumor cells hold great potential as drug delivery vehicles because of their good biosafety and natural transference of bioactive…”
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FUNDC1-dependent mitophagy induced by tPA protects neurons against cerebral ischemia-reperfusion injury by Cai, Ying, Yang, Eryan, Yao, Xiuhua, Zhang, Xuebin, Wang, Qixue, Wang, Yunfei, Liu, Ji, Fan, Weijia, Yi, Kaikai, Kang, Chunsheng, Wu, Jialing

“…Autophagy of mitochondria, termed mitophagy, plays an important role in cerebral ischemia-reperfusion (IR) injury, but the mechanism is not yet clear…”
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RUNX1 contributes to the mesenchymal subtype of glioblastoma in a TGFβ pathway-dependent manner by Zhao, Kai, Cui, Xiaoteng, Wang, Qixue, Fang, Chuan, Tan, Yanli, Wang, Yunfei, Yi, Kaikai, Yang, Chao, You, Hua, Shang, Rui, Wang, Jiachong, Kang, Chunsheng

“…Runt-Related Transcription Factor 1 (RUNX1) is highly expressed in the Mesenchymal (Mes) subtype of glioblastoma (GBM). However, the specific molecular…”
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The CRISPR‐Cas13a Gene‐Editing System Induces Collateral Cleavage of RNA in Glioma Cells by Wang, Qixue, Liu, Xing, Zhou, Junhu, Yang, Chao, Wang, Guangxiu, Tan, Yanli, Wu, Ye, Zhang, Sijing, Yi, Kaikai, Kang, Chunsheng

“…RNA is rarely used as a therapeutic target due to its flexible structure and instability. CRISPR‐Cas13a is a powerful tool for RNA knockdown, and the potential…”
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TCA-phospholipid-glycolysis targeted triple therapy effectively suppresses ATP production and tumor growth in glioblastoma by Yang, Shixue, Zhao, Jixing, Cui, Xiaoteng, Zhan, Qi, Yi, Kaikai, Wang, Qixue, Xiao, Menglin, Tan, Yanli, Hong, Biao, Fang, Chuan, Kang, Chunsheng

“…Glioblastoma (GBM) displays a complex metabolic reprogramming in cancer cells. Adenosine triphosphate (ATP) is one of the central mediators of cell metabolism…”
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Tumor Microenvironment‐Tailored Weakly Cell‐Interacted Extracellular Delivery Platform Enables Precise Antibody Release and Function by Li, Sidi, Chen, Luyang, Huang, Kai, Chen, Ning, Zhan, Qi, Yi, Kaikai, Qi, Hongzhao, Liu, Chaoyong, Tan, Yanli, Hou, Xin, Lu, Yunfeng, Zhao, Jin, Yuan, Xubo, Kang, Chunsheng

“…Precise delivery of extracellularly functional protein drugs is limited by the drawback in that the protective carrier often causes undesirable cellular uptake…”
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The role of PTRF/Cavin1 as a biomarker in both glioma and serum exosomes by Huang, Kai, Fang, Chuan, Yi, Kaikai, Liu, Xing, Qi, Hongzhao, Tan, Yanli, Zhou, Junhu, Li, Ying, Liu, Mingyang, Zhang, Yuqing, Yang, Jingxuan, Zhang, Jianning, Li, Min, Kang, Chunsheng

“…Exosomes play critical roles in intercellular communication in both nearby and distant cells in individuals and organs. Polymerase I and transcript release…”
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HOTAIR Up-Regulation Activates NF-κB to Induce Immunoescape in Gliomas by Wang, Yunfei, Yi, Kaikai, Liu, Xing, Tan, Yanli, Jin, Weili, Li, Yansheng, Zhou, Junhu, Wang, Hongjun, Kang, Chunsheng

“…Checkpoint blockade therapies targeting programmed death ligand 1 (PD-L1) and its receptor programmed cell death 1 promote T cell-mediated immune surveillance…”
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A Compound AC1Q3QWB Selectively Disrupts HOTAIR-Mediated Recruitment of PRC2 and Enhances Cancer Therapy of DZNep by Li, Yansheng, Ren, Yu, Wang, Yunfei, Tan, Yanli, Wang, Qixue, Cai, Jinquan, Zhou, Junhu, Yang, Chao, Zhao, Kai, Yi, Kaikai, Jin, Weili, Wang, Lin, Liu, Mingyang, Yang, Jingxuan, Li, Min, Kang, Chunsheng

“…Over 20% of cancer 'driver' genes encode chromatin regulators. Long noncoding RNAs (lincRNAs), which are dysregulated in various cancers, play a critical role…”
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PTRF/Cavin-1 as a Novel RNA-Binding Protein Expedites the NF-κB/PD-L1 Axis by Stabilizing lncRNA NEAT1, Contributing to Tumorigenesis and Immune Evasion in Glioblastoma by Yi, Kaikai, Cui, Xiaoteng, Liu, Xing, Wang, Yunfei, Zhao, Jixing, Yang, Shixue, Xu, Can, Yang, Eryan, Xiao, Menglin, Hong, Biao, Fang, Chuan, Kang, Chunsheng, Tan, Yanli, Wang, Qixue

“…Immunotherapy, especially checkpoint inhibitors targeting PD-1 or PD-L1, has revolutionized cancer therapy. However, PD-1/PD-L1 inhibitors have not been…”
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lncRNA PRADX is a Mesenchymal Glioblastoma Biomarker for Cellular Metabolism Targeted Therapy by Xu, Can, Zhao, Jixing, Song, Jia, Xiao, Menglin, Cui, Xiaoteng, Xin, Lei, Xu, Jianglong, Zhang, Yuhao, Yi, Kaikai, Hong, Biao, Tong, Fei, Tian, Shaohui, Tan, Yanli, Kang, Chunsheng, Fang, Chuan

“…Glioblastoma (GBM) is the most common and lethal type of primary malignant central nervous system (CNS) tumor with an extremely poor prognosis, and the…”
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EGFR-vIII downregulated H2AZK4/7AC though the PI3K/AKT-HDAC2 axis to regulate cell cycle progression by Zhao, Hongyu, Wang, Yunfei, Yang, Chao, Zhou, Junhu, Wang, Lin, Yi, Kaikai, Li, Yansheng, wang, Qixue, Shi, Jin, Kang, Chunsheng, Zeng, Liang

“…Background The EGFR-vIII mutation is the most common malignant event in GBM. Epigenetic reprogramming in EGFR-activated GBM has recently been suggested to…”
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Blockage of EGFR/AKT and mevalonate pathways synergize the antitumor effect of temozolomide by reprogramming energy metabolism in glioblastoma by Cui, Xiaoteng, Zhao, Jixing, Li, Guanzhang, Yang, Chao, Yang, Shixue, Zhan, Qi, Zhou, Junhu, Wang, Yunfei, Xiao, Menglin, Hong, Biao, Yi, Kaikai, Tong, Fei, Tan, Yanli, Wang, Hu, Wang, Qixue, Jiang, Tao, Fang, Chuan, Kang, Chunsheng

“…Background Metabolism reprogramming plays a vital role in glioblastoma (GBM) progression and recurrence by producing enough energy for highly proliferating…”
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Virus-like nanoparticle as a co-delivery system to enhance efficacy of CRISPR/Cas9-based cancer immunotherapy by Liu, Qi, Wang, Chun, Zheng, Yadan, Zhao, Yu, Wang, Ying, Hao, Jialei, Zhao, Xinzhi, Yi, Kaikai, Shi, Linqi, Kang, Chunsheng, Liu, Yang

“…The Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-associated protein 9 (Cas9) system holds great promise for the cancer gene therapy…”
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Blood exosomes-based targeted delivery of cPLA2 siRNA and metformin to modulate glioblastoma energy metabolism for tailoring personalized therapy by Zhan, Qi, Yi, Kaikai, Cui, Xiaoteng, Li, Xueping, Yang, Shixue, Wang, Qixue, Fang, Chuan, Tan, Yanli, Li, Lijie, Xu, Can, Yuan, Xubo, Kang, Chunsheng

“…Targeting glioblastoma (GBM) energy metabolism through multiple metabolic pathways has emerged as an effective therapeutic approach. Dual inhibition of…”
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Glioma-derived exosomes hijack the blood–brain barrier to facilitate nanocapsule delivery via LCN2 by Yang, Chao, Wu, Ye, Wang, Lin, Li, Sidi, Zhou, Junhu, Tan, Yanli, Song, Jia, Xing, Huike, Yi, Kaikai, Zhan, Qi, Zhao, Jin, Wang, Qixue, Yuan, Xubo, Kang, Chunsheng

“…Exosomes are small extracellular vehicles which could transport genetic materials and proteins between cells. Although there are reports about exosomes…”
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PTRF/cavin-1 remodels phospholipid metabolism to promote tumor proliferation and suppress immune responses in glioblastoma by stabilizing cPLA2 by Yi, Kaikai, Zhan, Qi, Wang, Qixue, Tan, Yanli, Fang, Chuan, Wang, Yunfei, Zhou, Junhu, Yang, Chao, Li, Yansheng, Kang, Chunsheng

“…Abstract Background Metabolism remodeling is a hallmark of glioblastoma (GBM) that regulates tumor proliferation and the immune microenvironment. Previous…”
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