Search Results - "Yeung, Ken K.‐C."
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Adolescent nicotine exposure induces long-term, sex-specific disturbances in mood and anxiety-related behavioral, neuronal and molecular phenotypes in the mesocorticolimbic system
Published in Neuropsychopharmacology (New York, N.Y.) (01-06-2024)“…The majority of lifetime smokers begin using nicotine during adolescence, a critical period of brain development wherein neural circuits critical for mood,…”
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Prenatal THC exposure induces long-term, sex-dependent cognitive dysfunction associated with lipidomic and neuronal pathology in the prefrontal cortex-hippocampal network
Published in Molecular psychiatry (01-10-2023)“…With increasing maternal cannabis use, there is a need to investigate the lasting impact of prenatal exposure to Δ9-tetrahydrocannabinol (THC), the main…”
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Membrane-lipid homeostasis in a prodromal rat model of Alzheimer's disease: Characteristic profiles in ganglioside distributions during aging detected using MALDI imaging mass spectrometry
Published in Biochimica et biophysica acta. General subjects (01-06-2018)“…Accumulation of simple gangliosides GM2 and GM3, and gangliosides with longer long-chain bases (d20:1) have been linked to toxicity and the pathogenesis of…”
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Environmental Concentrations of the Type 2 Diabetes Medication Metformin and Its Transformation Product Guanylurea in Surface Water and Sediment in Ontario and Quebec, Canada
Published in Environmental toxicology and chemistry (01-08-2023)“…Metformin, used to treat Type 2 diabetes, is the active ingredient of one of the most prescribed drugs in the world, with over 120 million yearly prescriptions…”
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5
Diagnostic fragmentation filtering for the discovery of new chaetoglobosins and cytochalasins
Published in Rapid communications in mass spectrometry (15-01-2019)“…Rationale Microbial natural products are often biosynthesized as classes of structurally related compounds that have similar tandem mass spectrometry (MS/MS)…”
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Detection of Amyloid Beta (Aβ) Oligomeric Composition Using Matrix-Assisted Laser Desorption Ionization Mass Spectrometry (MALDI MS)
Published in Journal of the American Society for Mass Spectrometry (01-04-2018)“…The use of MALDI MS as a fast and direct method to detect the Aβ oligomers of different masses is examined in this paper. Experimental results suggest that Aβ…”
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Diversity of Mycotoxin-Producing Black Aspergilli in Canadian Vineyards
Published in Journal of agricultural and food chemistry (24-02-2016)“…Several Aspergillus species produce ochratoxin A (OTA) and/or fumonisins on wine and table grapes. The relevant species and their mycotoxins have been…”
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Increased Expression of Simple Ganglioside Species GM2 and GM3 Detected by MALDI Imaging Mass Spectrometry in a Combined Rat Model of Aβ Toxicity and Stroke
Published in PloS one (18-06-2015)“…The aging brain is often characterized by the presence of multiple comorbidities resulting in synergistic damaging effects in the brain as demonstrated through…”
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Identification of six new Alternaria sulfoconjugated metabolites by high-resolution neutral loss filtering
Published in Rapid communications in mass spectrometry (15-10-2015)“…Rationale Many species of Alternaria damage important agricultural crops, including small grains and tomatoes. These fungi can produce a variety of secondary…”
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Insecticidal Activity of Bio-oil from the Pyrolysis of Straw from Brassica spp
Published in Journal of agricultural and food chemistry (23-04-2014)“…Agricultural crop residues can be converted through thermochemical pyrolysis to bio-oil, a sustainable source of biofuel and biochemicals. The pyrolysis…”
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Matrix‐assisted laser desorption/ionization imaging mass spectrometry of intraperitoneally injected danegaptide (ZP1609) for treatment of stroke‐reperfusion injury in mice
Published in Rapid communications in mass spectrometry (30-06-2018)“…Rationale This work focuses on direct matrix‐assisted laser desorption/ionization imaging mass spectrometry (MALDI‐IMS) detection of intraperitoneally…”
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The Impacts of Adolescent Cannabinoid Exposure on Striatal Anxiety- and Depressive-Like Pathophysiology Are Prevented by the Antioxidant N-Acetylcysteine
Published in Biological psychiatry global open science (01-11-2024)“…Exposure to Δ9-tetrahydrocannabinol (THC) is an established risk factor for later-life neuropsychiatric vulnerability, including mood- and anxiety-related…”
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Proteomic Analyses Detect Higher Expression of C-Type Lectins in Imidacloprid-Resistant Colorado Potato Beetle Leptinotarsa decemlineata Say
Published in Insects (Basel, Switzerland) (23-12-2020)“…The Colorado potato beetle (CPB) is one of the most adaptable insect pests to both plant toxins and synthetic insecticides. Resistance in CPB is reported for…”
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Production of a bio-magnetic adsorbent via co-pyrolysis of pine wood waste and red mud
Published in Waste management (Elmsford) (15-07-2022)“…[Display omitted] •Simultaneous waste biomass and red mud reduction and fabrication of magnetic adsorbent.•Comprehensive characterizations to reveal the…”
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Recent applications of capillary electrophoresis–mass spectrometry (CE–MS): CE performing functions beyond separation
Published in Analytica chimica acta (03-10-2008)“…Capillary electrophoresis is one of the separation tools commonly used in conjugation with mass spectrometry. Its primary purpose is to resolve the components…”
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1,6-Diphenyl-1,3,5-hexatriene (DPH) as a Novel Matrix for MALDI MS Imaging of Fatty Acids, Phospholipids, and Sulfatides in Brain Tissues
Published in Analytical chemistry (Washington) (05-12-2017)“…1,6-Diphenyl-1,3,5-hexatriene (DPH) is a commonly used fluorescence probe for studying cell membrane-lipids due to its affinity toward the acyl chains in the…”
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Ganglioside Detection from Formalin-Fixed Human Brain Tissue Utilizing MALDI Imaging Mass Spectrometry
Published in Journal of the American Society for Mass Spectrometry (04-03-2020)“…Matrix assisted laser desorption ionization (MALDI) imaging mass spectrometry (IMS) is used to perform mass spectrometric analysis directly on biological…”
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Imaging of Neurotransmitters and Small Molecules in Brain Tissues Using Laser Desorption/Ionization Mass Spectrometry Assisted with Zinc Oxide Nanoparticles
Published in Journal of the American Society for Mass Spectrometry (07-04-2021)“…Inorganic nanostructured materials such as silicon, carbon, metals, and metal oxides have been explored as matrices of low-background signals to assist the…”
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In-Capillary Protein Enrichment and Removal of Nonbuffering Salts Using Capillary Electrophoresis with Discontinuous Buffers
Published in Analytical chemistry (Washington) (15-11-2008)“…Salt is abundant in biological samples and can cause problems in capillary electrophoresis (CE) due to excessive Joule heating and electrodispersion. Desalting…”
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Sphingomyelins as semi-permanent capillary coatings for protein separations in CE and off-line analysis with MALDI-MS
Published in Electrophoresis (01-05-2009)“…Phosphatidylcholine (PC) is one of the major phospholipids that make up the biological cell membrane. It was previously reported to form capillary inner wall…”
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