Comparison of the Protoscolocidal Effectiveness of Hypertonic Saline, Povidone—Iodine and Albendazole Solutions in an Experimental Lung Hydatid Cyst Model

Secondary hydatidosis is an important problem encountered during the surgical treatment of hydatid cysts. This study describes an experimental model of secondary hydatidosis by cyst inoculation, used to explore whether simultaneous inoculation of protoscolocidal agents could prevent secondary hydati...

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Bibliographic Details
Published in:	Journal of international medical research Vol. 39; no. 4; pp. 1230 - 1238
Main Authors:	Yetim, T Durgun, Basoglu, A, Sengul, A Taslak, Yetim, I, Bekdemir, O Serdar, Hokelek, M
Format:	Journal Article
Language:	English
Published:	London, England SAGE Publications 01-08-2011
Subjects:	Albendazole - therapeutic use Animals Anthelmintics - therapeutic use Anti-Infective Agents, Local - therapeutic use Echinococcosis, Hepatic - diagnostic imaging Echinococcosis, Hepatic - drug therapy Echinococcosis, Hepatic - pathology Eosinophilia - diagnostic imaging Eosinophilia - drug therapy Eosinophilia - pathology Male Pneumothorax - diagnostic imaging Pneumothorax - drug therapy Pneumothorax - pathology Povidone-Iodine - therapeutic use Rabbits Saline Solution, Hypertonic - therapeutic use Tomography, X-Ray Computed Treatment Outcome Povidone—Iodine Hypertonic saline Albendazole Protoscolocidal agents Lung hydatidosis Experimental model
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Summary:	Secondary hydatidosis is an important problem encountered during the surgical treatment of hydatid cysts. This study describes an experimental model of secondary hydatidosis by cyst inoculation, used to explore whether simultaneous inoculation of protoscolocidal agents could prevent secondary hydatidosis. Fertile cyst fluid was injected into the pleural space of rabbits alone (group 1, n = 8), and in combination with 2% albendazole solution (group 2, n = 8), 20% hypertonic saline (group 3, n = 8) or 10% povidone—iodine (group 4, n = 8). Computed tomography imaging of the thorax, indirect haemagglutination (IHA) titres and eosinophil counts were used to determine cyst development. After 16 months, three control rabbits had pneumothorax, seven had cysts and four had parenchymal nodules. Histopatho logical investigation of nodules revealed 87.5% cyst formation. Pleural thickening was observed in rabbits from all groups. Cyst formation rates, IHA titres and eosinophilia counts were higher in group 1 than in groups 2 – 4. This study demonstrated the experimental formation of secondary hydatidosis and found that topical protoscolocidal agents were beneficial in preventing cyst recurrence.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0300-0605 1473-2300
DOI:	10.1177/147323001103900411