Search Results - "Yeomans, D. C."

Cytokine profile in human skin in response to experimental inflammation, noxious stimulation, and administration of a COX-inhibitor: A microdialysis study by Angst, M.S., Clark, J.D., Carvalho, B., Tingle, M., Schmelz, M., Yeomans, D.C.

“…Animal studies have documented a critical role for cytokines in cell signaling events underlying inflammation and pain associated with tissue injury. While…”
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Peripheral and central p38 MAPK mediates capsaicin-induced hyperalgesia by Sweitzer, S.M., Peters, M.C., Ma, J.Y., Kerr, I., Mangadu, R., Chakravarty, S., Dugar, S., Medicherla, S., Protter, A.A., Yeomans, D.C.

“…The stress-activated mitogen-activated protein kinase (MAPK) p38 is emerging as an important mediator of pain. The present study examined the possible…”
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Decrease in inflammatory hyperalgesia by herpes vector-mediated knockdown of Nav1.7 sodium channels in primary afferents by Yeomans, D C, Levinson, S R, Peters, M C, Koszowski, A G, Tzabazis, A Z, Gilly, W F, Wilson, S P

“…Induction of peripheral inflammation increases the expression of the Nav1.7 sodium channel in sensory neurons, potentially increasing their excitability…”
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Discovery of a selective, state-independent inhibitor of NaV1.7 by modification of guanidinium toxins by Pajouhesh, H., Beckley, J. T., Delwig, A., Hajare, H. S., Luu, G., Monteleone, D., Zhou, X., Ligutti, J., Amagasu, S., Moyer, B. D., Yeomans, D. C., Du Bois, J., Mulcahy, J. V.

“…The voltage-gated sodium channel isoform Na V 1.7 is highly expressed in dorsal root ganglion neurons and is obligatory for nociceptive signal transmission…”
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Nasal application of HSV encoding human preproenkephalin blocks craniofacial pain in a rat model of traumatic brain injury by Meidahl, A C, Klukinov, M, Tzabazis, A Z, Sorensen, J C, Yeomans, D C

“…According to Centers for Disease Control and Prevention, each year, an estimated 1.7 million Americans sustain a traumatic brain injury (TBI), which frequently…”
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Nociceptive responses to high and low rates of noxious cutaneous heating are mediated by different nociceptors in the rat: electrophysiological evidence by Yeomans, David C, Proudfit, Herbert K

“…Behavioral nociceptive responses evoked by relatively high rates of noxious radiant skin heating appear to be mediated by A delta nociceptor activation,…”
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Antihyperalgesic Effects of Infection with a Preproenkephalin-Encoding Herpes Virus by Wilson, Steven P., Yeomans, David C., Bender, Mary Ann, Lu, Ying, Goins, William F., Glorioso, Joseph C.

“…To test the utility of gene therapeutic approaches for the treatment of pain, a recombinant herpes simplex virus, type 1, has been engineered to contain the…”
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Antibody-mediated lung endothelium targeting: in vivo model on primates by BALYASNIKOVA, I. V, YEOMANS, D. C, MCDONALD, T. B, DANILOV, S. M

“…We have recently provided evidence that angiotensin-converting enzyme (ACE) is a rational target and anti-ACE monoclonal antibodies (mAbs) are suitable…”
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Gene therapy for trigeminal pain in mice by Tzabazis, A Z, Klukinov, M, Feliciano, D P, Wilson, S P, Yeomans, D C

“…The aim of this study was to test the efficacy of a single direct injection of viral vector encoding for encephalin to induce a widespread expression of the…”
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High-dose remifentanil prevents development of thermal hyperalgesia in a neuropathic pain model by Manering, N.A., Reuter, T., Ihmsen, H., Yeomans, D.C., Tzabazis, A.

“…Intraoperative nerve lesions can lead to chronic postoperative pain. There are conflicting data as to whether or not anaesthetics administered intraoperatively…”
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Differential antinociceptive effects of spinal opioids on foot withdrawal responses evoked by C fibre or Aδ nociceptor activation by Lu, Y, Pirec, V, Yeomans, D C

“…Intrathecal application of μ, δ, and κ opioids attenuate responses on several tests of animal nociception. However, the potency of these opioids differ…”
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Herpes virus-based recombinant herpes vectors: gene therapy for pain and molecular tool for pain science by Yeomans, D C, Wilson, S P

“…This paper reviews work by Yeomans and Wilson in the area of herpes vector-mediated gene transfer to sensory neurons. Beginning in 1997, these researchers have…”
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The Combined Effects of N-type Calcium Channel Blockers and Morphine on Aδ Versus C Fiber Mediated Nociception by Pirec, Vesna, Laurito, Charles E., Lu, Ying, Yeomans, David C.

“…Intrathecal mu opiates produce analgesia presynaptically by inhibiting calcium ion influx and postsynaptically by increasing potassium flux. Mu receptors are…”
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Antinociception induced by microinjection of substance P into the A7 catecholamine cell group in the rat by Yeomans, D C, Proudfit, H K

“…Stimulation of neurons in the ventromedial medulla produces antinociception that is mediated in part by indirect activation of pontospinal noradrenergic…”
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Ameroid rings for gradual chronic constriction of the sciatic nerve in rats: contribution of different nerves to neuropathic pain by Tzabazis, A., Kim, P.H., Sweitzer, S.M., Yeomans, D.C.

“…Mononeuropathy was induced by placing an ameroid ring around the sciatic nerve and was compared with chronic constriction injury (CCI) of the sciatic nerve…”
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Purification of adrenal chromaffin cells increases antinociceptive efficacy of xenotransplants without immunosuppression by Michalewicz, P, Laurito, C E, Pappas, G D, Lu, Y, Yeomans, D C

“…We have found that immunosuppression is necessary for the survival of xenogeneic adrenal medullary transplants. Because chromaffin cells are essentially…”
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Effects of systemic morphine on responses of primates to first or second pain sensations by Yeomans, D C, Cooper, B Y, Vierck, Jr, C J

“…Despite evidence that systemic morphine preferentially attenuates second pain sensations that are presumed to result from activation of unmyelinated (C)…”
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Purification of rat brain, rabbit aorta, and human platelet thromboxane A2/prostaglandin H2 receptors by immunoaffinity chromatography employing anti-peptide and anti-receptor antibodies by BORG, C, LIM, C. T, YEOMANS, D. C, DIETER, J. P, KOMIOTIS, D, ANDERSON, E. G, LE BRETON, G. C

“…In the present study, a new polyclonal antibody (TxAb) was raised against native thromboxane A2 (TXA2)/prostaglandin H2 (PGH2) receptor protein. Previously…”
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Projections of substance P-immunoreactive neurons located in the ventromedial medulla to the A7 noradrenergic nucleus of the rat demonstrated using retrograde tracing combined with immunocytochemistry by Yeomans, D C, Proudfit, H K

“…Stimulation of neurons located in the ventromedial medulla (VMM), including the nucleus raphe magnus (RMg), produces antinociception which appears to be…”
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Nociceptive responses to high and low rates of noxious cutaneous heating are mediated by different nociceptors in the rat: behavioral evidence by Yeomans, David C, Pirec, Vesna, Proudfit, Herbert K

“…Several lines of evidence suggest that different classes of nociceptive afferents mediate the responses produced by different rates of noxious skin heating…”
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