Search Results - "Yeoh, Sharon"

New tools for evaluating protein tyrosine sulfation and carbohydrate sulfation by Yeoh, Sharon, Bayliss, Richard

“…Sulfation is a common modification of extracelluar glycans and tyrosine residues on proteins, which is important in many signalling pathways and interactions…”
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EML4-ALK Variants: Biological and Molecular Properties, and the Implications for Patients by Sabir, Sarah R, Yeoh, Sharon, Jackson, George, Bayliss, Richard

“…Since the discovery of the fusion between EML4 (echinoderm microtubule associated protein-like 4) and ALK (anaplastic lymphoma kinase), EML4-ALK, in lung…”
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ALKing the flames of lung cancer immunosensitivity by Bayliss, Richard, Sarnowska, Elżbieta, Yeoh, Sharon, Sampson, Josephina

“…Immune checkpoint inhibitors (ICIs) are utilised in treating non-small cell lung cancer (NSCLC) by enhancing the immune response against cancer cells. However,…”
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On the molecular mechanisms of mitotic kinase activation by Bayliss, Richard, Fry, Andrew, Haq, Tamanna, Yeoh, Sharon

“…During mitosis, human cells exhibit a peak of protein phosphorylation that alters the behaviour of a significant proportion of proteins, driving a dramatic…”
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Mechanistic basis of Nek7 activation through Nek9 binding and induced dimerization by Haq, Tamanna, Richards, Mark W., Burgess, Selena G., Gallego, Pablo, Yeoh, Sharon, O’Regan, Laura, Reverter, David, Roig, Joan, Fry, Andrew M., Bayliss, Richard

“…Mitotic spindle assembly requires the regulated activities of protein kinases such as Nek7 and Nek9. Nek7 is autoinhibited by the protrusion of Tyr97 into the…”
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Plasmodium falciparum SERA5 plays a non‐enzymatic role in the malarial asexual blood‐stage lifecycle by Stallmach, Robert, Kavishwar, Manoli, Withers‐Martinez, Chrislaine, Hackett, Fiona, Collins, Christine R., Howell, Steven A., Yeoh, Sharon, Knuepfer, Ellen, Atid, Avshalom J., Holder, Anthony A., Blackman, Michael J.

“…Summary The malaria parasite Plasmodium falciparum replicates in an intraerythrocytic parasitophorous vacuole (PV). The most abundant P. falciparum PV protein,…”
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Subcellular Discharge of a Serine Protease Mediates Release of Invasive Malaria Parasites from Host Erythrocytes by Yeoh, Sharon, O'Donnell, Rebecca A., Koussis, Konstantinos, Dluzewski, Anton R., Ansell, Keith H., Osborne, Simon A., Hackett, Fiona, Withers-Martinez, Chrislaine, Mitchell, Graham H., Bannister, Lawrence H., Bryans, Justin S., Kettleborough, Catherine A., Blackman, Michael J.

“…The most virulent form of malaria is caused by waves of replication of blood stages of the protozoan pathogen Plasmodium falciparum. The parasite divides…”
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Design of Potent and Selective Hybrid Inhibitors of the Mitotic Kinase Nek2: Structure–Activity Relationship, Structural Biology, and Cellular Activity by Innocenti, Paolo, Cheung, Kwai-Ming J, Solanki, Savade, Mas-Droux, Corine, Rowan, Fiona, Yeoh, Sharon, Boxall, Kathy, Westlake, Maura, Pickard, Lisa, Hardy, Tara, Baxter, Joanne E, Aherne, G. Wynne, Bayliss, Richard, Fry, Andrew M, Hoelder, Swen

“…We report herein a series of Nek2 inhibitors based on an aminopyridine scaffold. These compounds have been designed by combining key elements of two previously…”
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Molecular identification of a malaria merozoite surface sheddase by Harris, Philippa K, Yeoh, Sharon, Dluzewski, Anton R, O'Donnell, Rebecca A, Withers-Martinez, Chrislaine, Hackett, Fiona, Bannister, Lawrence H, Mitchell, Graham H, Blackman, Michael J

“…Proteolytic shedding of surface proteins during invasion by apicomplexan parasites is a widespread phenomenon, thought to represent a mechanism by which the…”
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A multifunctional serine protease primes the malaria parasite for red blood cell invasion by Koussis, Konstantinos, Withers-Martinez, Chrislaine, Yeoh, Sharon, Child, Matthew, Hackett, Fiona, Knuepfer, Ellen, Juliano, Luiz, Woehlbier, Ute, Bujard, Hermann, Blackman, Michael J

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Structural features of the protein kinase domain and targeted binding by small-molecule inhibitors by Arter, Chris, Trask, Luke, Ward, Sarah, Yeoh, Sharon, Bayliss, Richard

“…Protein kinases are key components in cellular signaling pathways as they carry out the phosphorylation of proteins, primarily on Ser, Thr, and Tyr residues…”
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Uncoupling actin filament fragmentation by cofilin from increased subunit turnover by Pope, Brian J, Gonsior, Sabine M, Yeoh, Sharon, McGough, Amy, Weeds, Alan G

“…The actin depolymerizing factor (ADF)/cofilin family of proteins interact with actin monomers and filaments in a pH-sensitive manner. When ADF/cofilin binds…”
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The journey of Zika to the developing brain by Rombi, Francesca, Bayliss, Richard, Tuplin, Andrew, Yeoh, Sharon

“…Zika virus is a mosquito-borne Flavivirus originally isolated from humans in 1952. Following its re-emergence in Brazil in 2015, an increase in the number of…”
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The Ys and wherefores of protein kinase autoinhibition by Bayliss, Richard, Haq, Tamanna, Yeoh, Sharon

“…Protein phosphorylation is a key reaction in the regulation of cellular events and is catalysed by over 500 protein kinases in humans. The activities of…”
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Determining the differences in actin binding by human ADF and cofilin 1 1Edited by J. Karn by Yeoh, Sharon, Pope, Brian, Mannherz, Hans G, Weeds, Alan

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A kinetic test characterizes kinase intramolecular and intermolecular autophosphorylation mechanisms by Dodson, Charlotte A, Yeoh, Sharon, Haq, Tamanna, Bayliss, Richard

“…Many protein kinases catalyze their own activation by autophosphorylation. The mechanism of this is generally considered to be intermolecular and similar to…”
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Nek7 conformational flexibility and inhibitor binding probed through protein engineering of the R-spine by Byrne, Matthew J, Nasir, Nazia, Basmadjian, Christine, Bhatia, Chitra, Cunnison, Rory F, Carr, Katherine H, Mas-Droux, Corine, Yeoh, Sharon, Cano, Céline, Bayliss, Richard

“…Nek7 is a serine/threonine-protein kinase required for proper spindle formation and cytokinesis. Elevated Nek7 levels have been observed in several cancers,…”
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A multifunctional serine protease primes the malaria parasite for red blood cell invasion by Koussis, Konstantinos, Withers‐Martinez, Chrislaine, Yeoh, Sharon, Child, Matthew, Hackett, Fiona, Knuepfer, Ellen, Juliano, Luiz, Woehlbier, Ute, Bujard, Hermann, Blackman, Michael J

“…The malaria parasite Plasmodium falciparum replicates within an intraerythrocytic parasitophorous vacuole (PV). Rupture of the host cell allows release…”
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Identification of proteases that regulate erythrocyte rupture by the malaria parasite Plasmodium falciparum by Bogyo, Matthew, Arastu-Kapur, Shirin, Ponder, Elizabeth L, Fonovi, Urša Pe ar, Yeoh, Sharon, Yuan, Fang, Fonovi, Marko, Grainger, Munira, Phillips, Carolyn I, Powers, James C

“…Newly replicated Plasmodium falciparum parasites escape from host erythrocytes through a tightly regulated process that is mediated by multiple classes of…”
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Descriptive analysis of adult patients referred to the nepean family obesity service in the first six months of service operation by Ahn, Jeff, Chua, Verene, Wu, Yu-Fang, Badorrek, Sally, Lam, Sarah, Macdonald, Annette, Yeoh, Sharon, Williams, Kathryn

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