Search Results - "Yeo, Giselle C"
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Soluble matrix protein is a potent modulator of mesenchymal stem cell performance
Published in Proceedings of the National Academy of Sciences - PNAS (05-02-2019)“…We challenge the conventional designation of structural matrix proteins primarily as supporting scaffolds for resident cells. The extracellular matrix protein…”
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Extracellular Vesicles: Interplay with the Extracellular Matrix and Modulated Cell Responses
Published in International journal of molecular sciences (21-03-2022)“…The discovery that cells secrete extracellular vesicles (EVs), which carry a variety of regulatory proteins, nucleic acids, and lipids, has shed light on the…”
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Stress-induced senescence in mesenchymal stem cells: Triggers, hallmarks, and current rejuvenation approaches
Published in European journal of cell biology (01-06-2023)“…Mesenchymal stem cells (MSCs) have emerged as promising cell-based therapies in the treatment of degenerative and inflammatory conditions. However, despite…”
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Tropoelastin coated PLLA-PLGA scaffolds promote vascular network formation
Published in Biomaterials (01-04-2017)“…Abstract The robust repair of large wounds and tissue defects relies on blood flow. This vascularization is the major challenge faced by tissue engineering on…”
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Fabricated Elastin
Published in Advanced healthcare materials (18-11-2015)“…The mechanical stability, elasticity, inherent bioactivity, and self‐assembly properties of elastin make it a highly attractive candidate for the fabrication…”
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The Matrix Protein Tropoelastin Prolongs Mesenchymal Stromal Cell Vitality and Delays Senescence During Replicative Aging
Published in Advanced science (01-10-2024)“…Cellular senescence leads to the functional decline of regenerative cells such as mesenchymal stromal/stem cells (MSCs), which gives rise to chronic conditions…”
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Mechanical Properties of Plasma Immersion Ion Implanted PEEK for Bioactivation of Medical Devices
Published in ACS applied materials & interfaces (21-10-2015)“…Plasma immersion ion implantation (PIII) is used to modify the surface properties of polyether ether ketone for biomedical applications. Modifications to the…”
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Tropoelastin bridge region positions the cell-interactive C terminus and contributes to elastic fiber assembly
Published in Proceedings of the National Academy of Sciences - PNAS (21-02-2012)“…The tropoelastin monomer undergoes stages of association by coacervation, deposition onto microfibrils, and cross-linking to form elastic fibers. Tropoelastin…”
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A cost-effective and enhanced mesenchymal stem cell expansion platform with internal plasma-activated biofunctional interfaces
Published in Materials today bio (01-10-2023)“…Mesenchymal stem cells (MSCs) used for clinical applications require in vitro expansion to achieve therapeutically relevant numbers. However, conventional…”
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Plasma ion implantation enabled bio-functionalization of PEEK improves osteoblastic activity
Published in APL bioengineering (01-06-2018)“…Slow appositional growth of bone in vivo is a major problem associated with polyether ether ketone (PEEK) based orthopaedic implants. Early stage promotion of…”
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A New Vascular Engineering Strategy Using 3D Printed Ice
Published in Trends in biotechnology (Regular ed.) (01-05-2019)“…Vascular engineering requires integrating dimensional flexibility, strength, and bioactivity to fabricate materials that enable diffusive exchange of oxygen…”
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Characterization of Endothelial Progenitor Cell Interactions with Human Tropoelastin
Published in PloS one (26-06-2015)“…The deployment of endovascular implants such as stents in the treatment of cardiovascular disease damages the vascular endothelium, increasing the risk of…”
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Emerging concepts in bone repair and the premise of soft materials
Published in Current opinion in biotechnology (01-04-2022)“…[Display omitted] •New approaches in bone tissue engineering have been developed.•The generation of synthetic bone tissues reflective of native tissue…”
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Coacervation of tropoelastin
Published in Advances in colloid and interface science (14-09-2011)“…The coacervation of tropoelastin represents the first major stage of elastic fiber assembly. The process has been modeled in vitro by numerous studies,…”
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A cell adhesive peptide from tropoelastin promotes sequential cell attachment and spreading via distinct receptors
Published in The FEBS journal (01-07-2017)“…Tropoelastin is the dominant monomer that assembles to form elastin, which confers elasticity to vertebrate elastic tissues including skin, arteries, and…”
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Molecular model of human tropoelastin and implications of associated mutations
Published in Proceedings of the National Academy of Sciences - PNAS (10-07-2018)“…Protein folding poses unique challenges for large, disordered proteins due to the low resolution of structural data accessible in experiment and on the basis…”
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Hydrogel−Solid Hybrid Materials for Biomedical Applications Enabled by Surface‐Embedded Radicals
Published in Advanced functional materials (01-09-2020)“…Combinations of hydrogels and solids provide high level functionality for devices such as tissue engineering scaffolds and soft machines. However, the weak…”
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Domains 12 to 16 of tropoelastin promote cell attachment and spreading through interactions with glycosaminoglycan and integrins alphaV and alpha5beta1
Published in The FEBS journal (01-07-2021)“…Elastin is an extracellular matrix component with key structural and biological roles in elastic tissues. Interactions between resident cells and tropoelastin,…”
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Mapping the microcarrier design pathway to modernise clinical mesenchymal stromal cell expansion
Published in Trends in biotechnology (Regular ed.) (01-07-2024)“…The current limitations of commercial microcarriers for mesenchymal stromal cell (MSC) expansion are driving the demand for novel tuneable microcarriers.Novel…”
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Tropoelastin: A versatile, bioactive assembly module
Published in Acta biomaterialia (01-04-2014)“…Elastin provides structural integrity, biological cues and persistent elasticity to a range of important tissues, including the vasculature and lungs. Its…”
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