Search Results - "Yennek, Siham"
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Distinct metabolic states govern skeletal muscle stem cell fates during prenatal and postnatal myogenesis
Published in Journal of cell science (15-07-2018)“…During growth, homeostasis and regeneration, stem cells are exposed to different energy demands. Here, we characterise the metabolic pathways that mediate the…”
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Wnt4 is heterogeneously activated in maturing β-cells to control calcium signaling, metabolism and function
Published in Nature communications (21-10-2022)“…Diabetes is a multifactorial disorder characterized by loss or dysfunction of pancreatic β-cells. β-cells are heterogeneous, exhibiting different glucose…”
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Cell Adhesion Geometry Regulates Non-Random DNA Segregation and Asymmetric Cell Fates in Mouse Skeletal Muscle Stem Cells
Published in Cell reports (Cambridge) (22-05-2014)“…Cells of several metazoan species have been shown to non-randomly segregate their DNA such that older template DNA strands segregate to one daughter cell. The…”
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Intracellular Inactivation of Thyroid Hormone Is a Survival Mechanism for Muscle Stem Cell Proliferation and Lineage Progression
Published in Cell metabolism (02-12-2014)“…Precise control of the thyroid hormone (T3)-dependent transcriptional program is required by multiple cell systems, including muscle stem cells. Deciphering…”
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Apical Restriction of the Planar Cell Polarity Component VANGL in Pancreatic Ducts Is Required to Maintain Epithelial Integrity
Published in Cell reports (Cambridge) (26-05-2020)“…Cell polarity is essential for the architecture and function of numerous epithelial tissues. Here, we show that apical restriction of planar cell polarity…”
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Deconstructing the principles of ductal network formation in the pancreas
Published in PLoS biology (26-07-2018)“…The mammalian pancreas is a branched organ that does not exhibit stereotypic branching patterns, similarly to most other glands. Inside branches, it contains a…”
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Quantification of Visco-Elastic Properties of a Matrigel for Organoid Development as a Function of Polymer Concentration
Published in Frontiers in physics (30-10-2020)“…The biophysical properties of polymer based gels, for instance the commonly used Matrigel, crucially depend on polymer concentration. Only certain polymer…”
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Comparison of multiple transcriptomes exposes unified and divergent features of quiescent and activated skeletal muscle stem cells
Published in Skeletal muscle (22-12-2017)“…Skeletal muscle satellite (stem) cells are quiescent in adult mice and can undergo multiple rounds of proliferation and self-renewal following muscle injury…”
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Correction to: Comparison of multiple transcriptomes exposes unified and divergent features of quiescent and activated skeletal muscle stem cells
Published in Skeletal muscle (06-06-2018)“…After publication of this article [1], the authors noted that the legends for supplementary files Figures S3 and S4 were truncated in the production process,…”
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Towards a better understanding of diabetes mellitus using organoid models
Published in Nature reviews. Endocrinology (01-04-2023)“…Our understanding of diabetes mellitus has benefited from a combination of clinical investigations and work in model organisms and cell lines. Organoid models…”
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DNA asymmetry and cell fate regulation in stem cells
Published in Seminars in cell & developmental biology (01-08-2013)“…•Cell divisions can be invariant, or stochastic where they can potentially alternate between symmetric and asymmetric divisions.•We propose that all cell…”
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