Search Results - "Yenari, M A"

Transplanted Human Fetal Neural Stem Cells Survive, Migrate, and Differentiate in Ischemic Rat Cerebral Cortex by Kelly, S., Bliss, T. M., Shah, A. K., Sun, G. H., Ma, M., Foo, W. C., Masel, J., Yenari, M. A., Weissman, I. L., Uchida, N., Palmer, T., Steinberg, G. K.

“…We characterize the survival, migration, and differentiation of human neurospheres derived from CNS stem cells transplanted into the ischemic cortex of rats 7…”
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Apocynin improves outcome in experimental stroke with a narrow dose range by Tang, X.N, Cairns, B, Cairns, N, Yenari, M.A

“…Abstract Inflammation following ischemic stroke is known to contribute to injury. NADPH oxidase (NOX) is a major enzyme system originally studied in immune…”
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Pharmacological induction of the 70-kDa heat shock protein protects against brain injury by Kim, N, Kim, J.Y, Yenari, M.A

“…Highlights • We evaluate HSP70-inducer 17-AAG as therapy for traumatic brain injury. • We compare outcomes in a mouse TBI model using two treatment paradigms…”
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Antiapoptotic and Anti-inflammatory Mechanisms of Heat-Shock Protein Protection by YENARI, M. A.

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Regulation of inflammatory transcription factors by heat shock protein 70 in primary cultured astrocytes exposed to oxygen–glucose deprivation by Kim, J.Y, Yenari, M.A, Lee, J.E

“…Highlights • Hsp70 overexpression decreases phosphorylation of IκB, JNK and p38. • Hsp70 overexpression blunts DNA binding of their transcription factors. •…”
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Agmatine reduces infarct area in a mouse model of transient focal cerebral ischemia and protects cultured neurons from ischemia-like injury by Kim, J.H., Yenari, M.A., Giffard, R.G., Cho, S.W., Park, K.A., Lee, J.E.

“…Agmatine is a primary amine formed by the decarboxylation of l-arginine synthesized in mammalian brain. In this study, we investigated the neuroprotective…”
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Correlation of perfusion- and diffusion-weighted MRI with NIHSS score in acute (<6.5 hour) ischemic stroke by TONG, D. C, YENARI, M. A, ALBERS, G. W, O'BRIEN, M, MARKS, M. P, MOSELEY, M. E

“…Diffusion-weighted (DWI) and perfusion-weighted (PWI) MRI are powerful new techniques for the assessment of acute cerebral ischemia. However, quantitative data…”
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Mild hypothermia reduces ICAM-1 expression, neutrophil infiltration and microglia/monocyte accumulation following experimental stroke by Wang, G.J, Deng, H.Y, Maier, C.M, Sun, G.H, Yenari, M.A

“…Mild hypothermia is an established neuroprotectant against cerebral ischemic injury. Studies have shown that inflammation potentiates cerebral ischemic injury,…”
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Glutathione peroxidase overexpression inhibits cytochrome c release and proapoptotic mediators to protect neurons from experimental stroke by HOEHN, B, YENARI, M. A, SAPOLSKY, R. M, STEINBERG, G. K

“…Ischemic injury and reperfusion increases superoxide (O2-) production and reduces the ability of neurons to scavenge free radicals, leading to the release of…”
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Innate inflammatory responses in stroke: mechanisms and potential therapeutic targets by Kim, J Y, Kawabori, M, Yenari, M A

“…Stroke is a frequent cause of long-term disability and death worldwide. Ischemic stroke is more commonly encountered compared to hemorrhagic stroke, and leads…”
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Serial MRI after transient focal cerebral ischemia in rats: dynamics of tissue injury, blood-brain barrier damage, and edema formation by Neumann-Haefelin, T, Kastrup, A, de Crespigny, A, Yenari, M A, Ringer, T, Sun, G H, Moseley, M E

“…With the advent of thrombolytic therapy for acute stroke, reperfusion-associated mechanisms of tissue injury have assumed greater importance. In this…”
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Chronic treatment with simvastatin upregulates muscarinic M1/4 receptor binding in the rat brain by Wang, Q, Zengin, A, Ying, W, Newell, K.A, Wang, P, Yeo, W, Wong, P.T.-H, Yenari, M.A, Huang, X.-F

“…Abstract Statins are increasingly being used for the treatment of a variety of conditions beyond their original indication for cholesterol lowering. We…”
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Delayed induction and long-term effects of mild hypothermia in a focal model of transient cerebral ischemia : neurological outcome and infarct size by MAIER, Carolina M, GUO HUA SUN, KUNIS, David, YENARI, Midori A, STEINBERG, Gary K

“…The goals of this study were to determine the effects of delaying induction of mild hypothermia (33 degrees C) after transient focal cerebral ischemia and to…”
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Gene therapy with HSP72 is neuroprotective in rat models of stroke and epilepsy by Yenari, M A, Fink, S L, Sun, G H, Chang, L K, Patel, M K, Kunis, D M, Onley, D, Ho, D Y, Sapolsky, R M, Steinberg, G K

“…Brain areas damaged by stroke and seizures express high levels of the 72-kd heat shock protein (HSP72). Whether HSP72 represents merely a marker of stress or…”
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Stroke: molecular mechanisms and potential targets for treatment by Zheng, Z, Lee, J E, Yenari, M A

“…Significant advances have been made over the past few years concerning the cellular and molecular events underlying ischemic cell death. The brain succumbs to…”
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Influence of therapeutic hypothermia on regeneration after cerebral ischemia by Yenari, M A, Han, H S

“…The protective effect of therapeutic hypothermia in cerebral ischemia is well accepted in experimental models, and some clinical studies show that there is…”
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Hu23F2G, an Antibody Recognizing the Leukocyte CD11/CD18 Integrin, Reduces Injury in a Rabbit Model of Transient Focal Cerebral Ischemia by Yenari, Midori A., Kunis, David, Sun, Guo Hua, Onley, David, Watson, Linda, Turner, Stephanie, Whitaker, Steven, Steinberg, Gary K.

“…Neutrophils are known to mediate injury in acute ischemic stroke especially during reperfusion. Migration of neutrophils into regions of ischemic injury…”
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Post-ischemic inflammation: molecular mechanisms and therapeutic implications by Zheng, Zhen, Yenari, Midori A.

“…Ischemic stroke is characterized by the disruption of cerebral blood flow (CBF). This reduction of CBF results in energy failure and secondary biochemical…”
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Thrombolysis with tissue plasminogen activator (tPA) is temperature dependent by Yenari, Midori A., Palmer, James T., Bracci, P.M., Steinberg, Gary K.

“…Thrombolysis with tissue plasminogen activator (tPA) and hypothermia are two potential treatment modalities for acute ischemic stroke. Many investigators are…”
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SNX-111, a novel, presynaptic N-type calcium channel antagonist, is neuroprotective against focal cerebral ischemia in rabbits by Perez-Pinzon, Miguel A, Yenari, Midori A, Sun, Guo H, Kunis, David M, Steinberg, Gary K

“…Cytosolic Ca 2+ overload has been proposed as a main cause of neuronal injury during cerebral ischemia. SNX-111, a synthetic product of the naturally occurring…”
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