Search Results - "Yen-Pei Christy Chang"

Haploinsufficiency of Telomerase Reverse Transcriptase Leads to Anticipation in Autosomal Dominant Dyskeratosis Congenita by Mary Armanios, Chen, Jiunn-Liang, Yen-Pei Christy Chang, Brodsky, Robert A., Anita Hawkins, Griffin, Constance A., James R. Eshleman, Cohen, Alan R., Chakravarti, Aravinda, Hamosh, Ada, Greider, Carol W.

“…Dyskeratosis congenita is a rare inherited disorder characterized by abnormal skin manifestations. Morbidity and mortality from this disease is usually due to…”
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Allele-specific enhancers mediate associations between LCAT and ABCA1 polymorphisms and HDL metabolism by Howard, Alicia D, Wang, Xiaochun, Prasad, Megana, Sahu, Avinash Das, Aniba, Radhouane, Miller, Michael, Hannenhalli, Sridhar, Chang, Yen-Pei Christy

“…For most complex traits, the majority of SNPs identified through genome-wide association studies (GWAS) reside within noncoding regions that have no known…”
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Multiple Genes for Essential-Hypertension Susceptibility on Chromosome 1q by Chang, Yen-Pei Christy, Liu, Xin, Kim, James Dae Ok, Ikeda, Morna A., Layton, Marnie R., Weder, Alan B., Cooper, Richard S., Kardia, Sharon L.R., Rao, D.C., Hunt, Steve C., Luke, Amy, Boerwinkle, Eric, Chakravarti, Aravinda

“…Essential hypertension, defined as elevated levels of blood pressure (BP) without any obvious cause, is a major risk factor for coronary heart disease, stroke,…”
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Prediction and Subtyping of Hypertension from Pan-Tissue Transcriptomic and Genetic Analyses by Basu, Mahashweta, Sharmin, Mahfuza, Das, Avinash, Nair, Nishanth Ulhas, Wang, Kun, Lee, Joo Sang, Chang, Yen-Pei Christy, Ruppin, Eytan, Hannenhalli, Sridhar

“…(HT) is a complex systemic disease involving transcriptional changes in multiple organs. Here we systematically investigate the pan-tissue transcriptional and…”
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Leveraging linkage evidence to identify low-frequency and rare variants on 16p13 associated with blood pressure using TOPMed whole genome sequencing data by He, Karen Y., Li, Xiaoyin, Kelly, Tanika N., Liang, Jingjing, Cade, Brian E., Assimes, Themistocles L., Becker, Lewis C., Beitelshees, Amber L., Bress, Adam P., Chang, Yen-Pei Christy, Chen, Yii-Der Ida, de Vries, Paul S., Fox, Ervin R., Franceschini, Nora, Furniss, Anna, Gao, Yan, Guo, Xiuqing, Haessler, Jeffrey, Hwang, Shih-Jen, Irvin, Marguerite Ryan, Kalyani, Rita R., Liu, Ching-Ti, Liu, Chunyu, Martin, Lisa Warsinger, Montasser, May E., Muntner, Paul M., Mwasongwe, Stanford, Palmas, Walter, Reiner, Alex P., Shimbo, Daichi, Smith, Jennifer A., Snively, Beverly M., Yanek, Lisa R., Boerwinkle, Eric, Correa, Adolfo, Cupples, L. Adrienne, He, Jiang, Kardia, Sharon L. R., Kooperberg, Charles, Mathias, Rasika A., Mitchell, Braxton D., Psaty, Bruce M., Vasan, Ramachandran S., Rao, D. C., Rich, Stephen S., Rotter, Jerome I., Wilson, James G., Chakravarti, Aravinda, Morrison, Alanna C., Levy, Daniel, Arnett, Donna K., Redline, Susan, Zhu, Xiaofeng

“…In this study, we investigated low-frequency and rare variants associated with blood pressure (BP) by focusing on a linkage region on chromosome 16p13. We used…”
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The impact of data quality on the identification of complex disease genes: experience from the Family Blood Pressure Program by CHANG, Yen-Pei Christy, KIM, James Dae-Ok, KARDIA, Sharon L. R, QUERTERMOUS, Thomas, CHAKRAVARTI, Aravinda, SCHWANDER, Karen, RAO, Dabeeru C, MILLER, Mike B, WEDER, Alan B, COOPER, Richard S, SCHORK, Nicholas J, PROVINCE, Michael A, MORRISON, Alanna C

“…The application of genome-wide linkage scans to uncover susceptibility loci for complex diseases offers great promise for the risk assessment, treatment, and…”
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Epigenomic model of cardiac enhancers with application to genome wide association studies by Sahu, Avinash Das, Aniba, Radhouane, Chang, Yen-Pei Christy, Hannenhalli, Sridhar

“…Mammalian gene regulation is often mediated by distal enhancer elements, in particular, for tissue specific and developmental genes. Computational…”
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OPRM1 rs1799971, COMT rs4680, and FAAH rs324420 genes interact with placebo procedures to induce hypoalgesia by Colloca, Luana, Wang, Yang, Martinez, Pedro E, Chang, Yen-Pei C, Ryan, Kathleen A, Hodgkinson, Colin, Goldman, David, Dorsey, Susan G

“…Genetics studies on the placebo hypoalgesic effect highlight a promising link between single nucleotide polymorphisms (SNPs) in the dopamine, opioid, and…”
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OPRM1 rs1799971, COMT rs4680, and FAAH rs324420 genes interact with placebo procedures to induce hypoalgesia by Colloca, Luana, Wang, Yang, Martinez, Pedro E., Chang, Yen-Pei C., Ryan, Kathleen A., Hodgkinson, Colin, Goldman, David, Dorsey, Susan G.

“…Genetics studies on the placebo hypoalgesic effect highlight a promising link between single nucleotide polymorphisms (SNPs) in the dopamine, opioid, and…”
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Functional characterization of blood pressure‐associated common variants in STK39 by Chang, Yen Pei Christy, Chen, Junji, Wang, Ying, Dorff, Sarah, Wade, James, O'Connell, Jeff, Shuldiner, Alan

“…Abstract only…”
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Multiple Genes for Essential-Hypertension Susceptibility on Chromosome lq by Yen-Pei, Christy Chang, Liu, Xin, Kim, James Dae Ok, Ikeda, Morna A

“…Essential hypertension, defined as elevated levels of blood pressure (BP) without any obvious cause, is a major risk factor for coronary heart disease, stroke,…”
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Haploinsufficiency of t e lomerase reverse transcriptase leads to anticipation in autosomal dominant dyskeratosis congenita by Armanios, Mary, Chen, Jiunn-Liang, Chang, Yen-Pei Christy, Brodsky, Robert A., Hawkins, Anita, Griffin, Constance A., Eshleman, James R., Cohen, Alan R., Chakravarti, Aravinda, Hamosh, Ada, Greider, Carol W.

“…Dyskeratosis congenita is a rare inherited disorder characterized by abnormal skin manifestations. Morbidity and mortality from this disease is usually due to…”
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Genetic and functional analyses of the F cell production locus by Chang, Yen-Pei Christy

“…Fetal hemoglobin (Hb F, $\alpha\sb2\beta\sb2)$ production in adults is confined to a subset of erythrocytes termed F cells. The levels of Hb F and F cells are…”
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