Search Results - "Yen‐Pon, Expédite"

Strain‐Promoted 1,3‐Dithiolium‐4‐olates–Alkyne Cycloaddition by Kumar, Ramar Arun, Pattanayak, Manas R., Yen‐Pon, Expédite, Eliyan, Jijy, Porte, Karine, Bernard, Sabrina, Riomet, Margaux, Thuéry, Pierre, Audisio, Davide, Taran, Frédéric

“…Reported here is the reactivity of mesoionic 1,3‐dithiolium‐4‐olates towards strained alkynes, leading to thiophene cycloaddition products. In the process, the…”
Get full text

Strain‐Promoted 1,3‐Dithiolium‐4‐olates–Alkyne Cycloaddition by Kumar, Ramar Arun, Pattanayak, Manas R., Yen‐Pon, Expédite, Eliyan, Jijy, Porte, Karine, Bernard, Sabrina, Riomet, Margaux, Thuéry, Pierre, Audisio, Davide, Taran, Frédéric

“…Reported here is the reactivity of mesoionic 1,3‐dithiolium‐4‐olates towards strained alkynes, leading to thiophene cycloaddition products. In the process, the…”
Get full text

On-DNA Hydroalkylation to Introduce Diverse Bicyclo[1.1.1]pentanes and Abundant Alkyls via Halogen Atom Transfer by Yen-Pon, Expédite, Li, Longbo, Levitre, Guillaume, Majhi, Jadab, McClain, Edward J., Voight, Eric A., Crane, Erika A., Molander, Gary A.

“…DNA-encoded libraries have proven their tremendous value in the identification of new lead compounds for drug discovery. To access libraries in new chemical…”
Get full text

Sydnone-Based Approach to Heterohelicenes through 1,3-Dipolar-Cycloadditions by Yen-Pon, Expédite, Champagne, Pier Alexandre, Plougastel, Lucie, Gabillet, Sandra, Thuéry, Pierre, Johnson, Mizuki, Muller, Gilles, Pieters, Grégory, Taran, Frédéric, Houk, K. N, Audisio, Davide

“…The first approach to pyrazole-containing helicenes via sydnone-aryne [3 + 2]-cycloaddition is described. An unprecedented regioselectivity in the…”
Get full text

Exploiting the sp2 character of bicyclo[1.1.1]pentyl radicals in the transition-metal-free multi-component difunctionalization of [1.1.1]propellane by Dong, Weizhe, Yen-Pon, Expédite, Li, Longbo, Bhattacharjee, Ayan, Jolit, Anais, Molander, Gary A.

“…Strained bicyclic substructures are increasingly relevant in medicinal chemistry discovery research because of their role as bioisosteres. Over the last…”
Get full text

Design, Synthesis, and Biological Evaluation of Covalent Inhibitors of Focal Adhesion Kinase (FAK) against Human Malignant Glioblastoma by Li, Bo, Li, Yongliang, Tomkiewicz-Raulet, Céline, Dao, Pascal, Lietha, Daniel, Yen-Pon, Expédite, Du, Zhiyun, Coumoul, Xavier, Garbay, Christiane, Etheve-Quelquejeu, Mélanie, Chen, Huixiong

“…Human malignant glioblastoma (GBM) is a highly invasive and lethal brain tumor. Targeting of integrin downstream signaling mediators in GBM such as focal…”
Get full text

Reversing Reactivity: Stereoselective Desulfurative 1,2-trans-O‑Glycosylation of Anomeric Thiosugars with Carboxylic Acids under Copper or Cobalt Catalysis by Bennai, Nedjwa, Chabrier, Amélie, Fatthalla, Maha I, Tran, Christine, Yen-Pon, Expédite, Belkadi, Mohamed, Alami, Mouâd, Grimaud, Laurence, Messaoudi, Samir

“…We have discovered a new mode of reactivity of 1-thiosugars in the presence of Cu­(II) or Co­(II) for a stereoselective O-glycosylation reaction. The process…”
Get full text

Heterohelicenes through 1,3-Dipolar Cycloaddition of Sydnones with Arynes: Synthesis, Origins of Selectivity, and Application to pH-Triggered Chiroptical Switch with CPL Sign Reversal by Yen-Pon, Expédite, Buttard, Floris, Frédéric, Lucas, Thuéry, Pierre, Taran, Frédéric, Pieters, Grégory, Champagne, Pier Alexandre, Audisio, Davide

“…Regioselective access to heterohelicenes through the 1,3-dipolar cycloaddition of sydnones with arynes is described. Novel access to sydnones and…”
Get full text

Convergent Strategy to Dizocilpine MK-801 and Derivatives by Vardhan Reddy, K. Harsha, Yen-Pon, Expédite, Cohen-Kaminsky, Sylvia, Messaoudi, Samir, Alami, Mouad

“…A convergent total synthesis of MK-801 has been achieved. Key synthetic transformations include a multicomponent Barbier-type reaction to construct the…”
Get full text

Design, Synthesis, and Evaluation of Novel Imidazo[1,2‑a][1,3,5]triazines and Their Derivatives as Focal Adhesion Kinase Inhibitors with Antitumor Activity by Dao, Pascal, Smith, Nikaia, Tomkiewicz-Raulet, Céline, Yen-Pon, Expédite, Camacho-Artacho, Marta, Lietha, Daniel, Herbeuval, Jean-Phillipe, Coumoul, Xavier, Garbay, Christiane, Chen, Huixiong

“…A series of triazinic inhibitors of focal adhesion kinase (FAK) have been recently shown to exert antiangiogenic activity against HUVEC cells and anticancer…”
Get full text

Structure-Based Design, Synthesis, and Characterization of the First Irreversible Inhibitor of Focal Adhesion Kinase by Yen-Pon, Expédite, Li, Bo, Acebrón-Garcia-de-Eulate, Marta, Tomkiewicz-Raulet, Céline, Dawson, John, Lietha, Daniel, Frame, Margaret C, Coumoul, Xavier, Garbay, Christiane, Etheve-Quelquejeu, Mélanie, Chen, Huixiong

“…Focal Adhesion Kinase signaling pathway and its functions have been involved in the development and aggressiveness of tumor malignancy, it then presents a…”
Get full text

Fluorogenic probes based on polycyclic sydnone scaffolds by Plougastel, Lucie, Lamaa, Diana, Yen-Pon, Expédite, Audisio, Davide, Taran, Frédéric

“…We report the synthesis, photophysical characterization and kinetics of a series of polycyclic sydnone derivatives as a potential new class of fluorogenic…”
Get full text

Microwave-assisted synthesis of 2,5-disubstituted pyrimidine derivatives via Buchwald-Hartwig amination by Li, Bo, Etheve-Quelquejeu, Mélanie, Yen-Pon, Expédite, Garbay, Christiane, Chen, Huixiong

“…[Display omitted] •A practical procedure was developed to prepare 2,5-disubstituted pyrimidines.•The method has a wide range of substrate scope and good…”
Get full text

Padlocking dihydrofurannulation for the control of small degree of helicity built on a fused-tetracyclic core by Gaucherand, Arthur, Yen-Pon, Expédite, García-López, Diego, Naubron, Jean-Valère, Chentouf, Sara, Giorgi, Michel, Humbel, Stéphane, Jean, Marion, Rodriguez, Jean, Bonne, Damien

“…Enantioselective construction of small molecules displaying a configurationally stable helical shape built on a fused-tetracyclic core is a daunting synthetic…”
Get full text

Synthesis of aryl-thioglycopeptides through chemoselective Pd-mediated conjugation by Montoir, David, Amoura, Mehdi, Ababsa, Zine El Abidine, Vishwanatha, T M, Yen-Pon, Expédite, Robert, Vincent, Beltramo, Massimiliano, Piller, Véronique, Alami, Mouad, Aucagne, Vincent, Messaoudi, Samir

“…We describe herein a Pd-catalyzed methodology for the thioglycoconjugation of iodoaryl peptides and aminoacids. This operationally simple process occurs under…”
Get full text

Correction: Padlocking dihydrofurannulation for the control of small degree of helicity built on a fused-tetracyclic core by Gaucherand, Arthur, Yen-Pon, Expédite, García-López, Diego, Naubron, Jean-Valère, Chentouf, Sara, Giorgi, Michel, Humbel, Stéphane, Jean, Marion, Rodriguez, Jean, Bonne, Damien

“…[This corrects the article DOI: 10.1039/D4SC00745J.]…”
Get full text

Sydnone-Based Approach to Heterohelicenes through 1,3-Dipolar-Cycloadditions by Yen-Pon, Expédite, Champagne, Pier Alexandre, Plougastel, Lucie, Gabillet, Sandra, Thuéry, Pierre, Johnson, Mizuki, Muller, Gilles, Pieters, Grégory, Taran, Frédéric, Houk, K., Audisio, Davide

Get full text

Sydnone-based Approach to Hetero-helicenes Through 1,3-Dipolar-Cycloadditions by Yen-Pon, Expédite, Champagne, Pier Alexandre, Plougastel, Lucie, Gabillet, Sandra, Thuéry, Pierre, Johnson, Mizuki, Muller, Gilles, Pieters, Grégory, Taran, Frédéric, Houk, Kendall N, Audisio, Davide

“…The first approach to pyrazole containing helicenes via sydnone-aryne [3+2]-cycloaddition is described. An unprecedented regioselectivity in the cycloaddition…”
Get full text

Exploiting the sp 2 character of bicyclo[1.1.1]pentyl radicals in the transition-metal-free multi-component difunctionalization of [1.1.1]propellane by Dong, Weizhe, Yen-Pon, Expédite, Li, Longbo, Bhattacharjee, Ayan, Jolit, Anais, Molander, Gary A

“…Strained bicyclic substructures are increasingly relevant in medicinal chemistry discovery research because of their role as bioisosteres. Over the last…”
Get full text

Synthesis of aryl-thioglycopeptides through chemoselective Pd-mediated conjugationElectronic supplementary information (ESI) available: General, experimental procedures, and characterization of all new compounds. See DOI: 10.1039/c8sc02370k by Montoir, David, Amoura, Mehdi, Ababsa, Zine El Abidine, Vishwanatha, T. M, Yen-Pon, Expédite, Robert, Vincent, Beltramo, Massimiliano, Piller, Véronique, Alami, Mouad, Aucagne, Vincent, Messaoudi, Samir

“…We describe herein a Pd-catalyzed methodology for the thioglycoconjugation of iodoaryl peptides and aminoacids. This operationally simple process occurs under…”
Get full text