Search Results - "Yen, Tim J"

Thyroid Hormone Receptor Interacting Protein 13 (TRIP13) AAA-ATPase Is a Novel Mitotic Checkpoint-silencing Protein by Wang, Kexi, Sturt-Gillespie, Brianne, Hittle, James C., Macdonald, Dawn, Chan, Gordon K., Yen, Tim J., Liu, Song-Tao

“…The mitotic checkpoint (or spindle assembly checkpoint) is a fail-safe mechanism to prevent chromosome missegregation by delaying anaphase onset in the…”
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OTSSP167 Abrogates Mitotic Checkpoint through Inhibiting Multiple Mitotic Kinases by Ji, Wenbin, Arnst, Christopher, Tipton, Aaron R, Bekier, 2nd, Michael E, Taylor, William R, Yen, Tim J, Liu, Song-Tao

“…OTSSP167 was recently characterized as a potent inhibitor for maternal embryonic leucine zipper kinase (MELK) and is currently tested in Phase I clinical…”
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Protein Architecture of the Human Kinetochore Microtubule Attachment Site by Wan, Xiaohu, O'Quinn, Ryan P., Pierce, Heather L., Joglekar, Ajit P., Gall, Walt E., DeLuca, Jennifer G., Carroll, Christopher W., Liu, Song-Tao, Yen, Tim J., McEwen, Bruce F., Stukenberg, P. Todd, Desai, Arshad, Salmon, E.D.

“…Chromosome segregation requires assembly of kinetochores on centromeric chromatin to mediate interactions with spindle microtubules and control cell-cycle…”
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Oncogenic Ras Regulates BRIP1 Expression to Induce Dissociation of BRCA1 from Chromatin, Inhibit DNA Repair, and Promote Senescence by Tu, Zhigang, Aird, Katherine M., Bitler, Benjamin G., Nicodemus, Jasmine P., Beeharry, Neil, Xia, Bing, Yen, Tim J., Zhang, Rugang

“…Here, we report a cell-intrinsic mechanism by which oncogenic RAS promotes senescence while predisposing cells to senescence bypass by allowing for secondary…”
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Checkpoint Inhibition of the APC/C in HeLa Cells Is Mediated by a Complex of BUBR1, BUB3, CDC20, and MAD2 by Sudakin, Valery, Gordon K. T. Chan, Yen, Tim J.

“…The mitotic checkpoint prevents cells with unaligned chromosomes from prematurely exiting mitosis by inhibiting the anaphase-promoting complex/cyclosome…”
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Clinical and Molecular Features of Anti-CENP-B Autoantibodies by Prasad, Rahul M., Bellacosa, Alfonso, Yen, Tim J.

“…Centromeric proteins are the foundation for assembling the kinetochore, a macromolecular complex that is essential for accurate chromosome segregation during…”
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The RanGAP1-RanBP2 Complex Is Essential for Microtubule-Kinetochore Interactions In Vivo by Joseph, Jomon, Liu, Song-Tao, Jablonski, Sandra A, Yen, Tim J, Dasso, Mary

“…RanGAP1 is the activating protein for the Ran GTPase. Vertebrate RanGAP1 is conjugated to a small ubiquitin-like protein, SUMO-1 [1, 2]. This modification…”
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Tripin/hSgo2 recruits MCAK to the inner centromere to correct defective kinetochore attachments by Huang, Haomin, Feng, Jie, Famulski, Jakub, Rattner, Jerome B, Liu, Song Tao, Kao, Gary D, Muschel, Ruth, Chan, Gordon K.T, Yen, Tim J

“…hSgo2 (previously annotated as Tripin) was recently reported to be a new inner centromere protein that is essential for centromere cohesion (Kitajima et al.,…”
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Role of the Tetradecapeptide Repeat Domain of Human Histone Deacetylase 6 in Cytoplasmic Retention by Bertos, Nicholas R, Gilquin, Benoit, Chan, Gordon K T, Yen, Tim J, Khochbin, Saadi, Yang, Xiang-Jiao

“…Histone deacetylase 6 (HDAC6) contains tandem catalytic domains and a ubiquitin-binding zinc finger and displays deacetylase activity toward acetylated…”
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Microtubule-dependent changes in assembly of microtubule motor proteins and mitotic spindle checkpoint proteins at PtK1 kinetochores by Hoffman, D B, Pearson, C G, Yen, T J, Howell, B J, Salmon, E D

“…The ability of kinetochores to recruit microtubules, generate force, and activate the mitotic spindle checkpoint may all depend on microtubule- and/or…”
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Human MPS1 kinase is required for mitotic arrest induced by the loss of CENP-E from kinetochores by Liu, Song-Tao, Chan, Gordon K T, Hittle, James C, Fujii, Gregory, Lees, Emma, Yen, Tim J

“…We have determined that the previously identified dual-specificity protein kinase TTK is the human orthologue of the yeast MPS1 kinase. Yeast MPS1 (monopolar…”
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Inhibitors of Histone Deacetylases Alter Kinetochore Assembly by Disrupting Pericentromeric Heterochromatin by Robbins, April R., Jablonski, Sandra A., Yen, Tim J., Yoda, Kinya, Robey, Rob, Bates, Susan E., Sackett, Dan L.

“…The kinetochore, a multi-protein complex assembled on centromeric chromatin in mitosis, is essential for sister chromosome segregation. We show here that…”
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Human CENP-I specifies localization of CENP-F, MAD1 and MAD2 to kinetochores and is essential for mitosis by Yen, Tim J, Liu, Song-Tao, Hittle, James C, Jablonski, Sandra A, Campbell, Michael S, Yoda, Kinya

“…The kinetochore, a macromolecular complex located at the centromere of chromosomes, provides essential functions for accurate chromosome segregation…”
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Specification of kinetochore-forming chromatin by the histone H3 variant CENP-A by Van Hooser, A A, Ouspenski, I I, Gregson, H C, Starr, D A, Yen, T J, Goldberg, M L, Yokomori, K, Earnshaw, W C, Sullivan, K F, Brinkley, B R

“…The mechanisms that specify precisely where mammalian kinetochores form within arrays of centromeric heterochromatin remain largely unknown. Localization of…”
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Assembly of the SMRT-histone deacetylase 3 repression complex requires the TCP-1 ring complex by Guenther, Matthew G, Yu, Jiujiu, Kao, Gary D, Yen, Tim J, Lazar, Mitchell A

“…The acetylation of histone tails is a primary determinant of gene activity. Histone deacetylase 3 (HDAC3) requires the nuclear receptor corepressor SMRT for…”
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Two different mitotic checkpoint inhibitors of the anaphase-promoting complex/cyclosome antagonize the action of the activator Cdc20 by Eytan, Esther, Braunstein, Ilana, Ganoth, Dvora, Teichner, Adar, Hittle, James C, Yen, Tim J, Hershko, Avram

“…The mitotic checkpoint system ensures the fidelity of chromosome segregation by preventing the completion of mitosis in the presence of any misaligned…”
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Disassembly of mitotic checkpoint complexes by the joint action of the AAA-ATPase TRIP13 and p31(comet) by Eytan, Esther, Wang, Kexi, Miniowitz-Shemtov, Shirly, Sitry-Shevah, Danielle, Kaisari, Sharon, Yen, Tim J, Liu, Song-Tao, Hershko, Avram

“…The mitotic (or spindle assembly) checkpoint system delays anaphase until all chromosomes are correctly attached to the mitotic spindle. When the checkpoint is…”
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Inhibition of Centrosome Separation after DNA Damage: A Role for Nek2 by Fletcher, Lynda, Cerniglia, George J., Nigg, Erich A., Yen, Tim J., Muschel, Ruth J.

“…Fletcher, L., Cerniglia, G. J., Nigg, E. A., Yen, T. J. and Muschel, R. J. Inhibition of Centrosome Separation after DNA Damage: A Role for Nek2. Radiat. Res…”
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Evidence That the Retroviral DNA Integration Process Triggers an ATR-Dependent DNA Damage Response by Daniel, René, Kao, Gary, Taganov, Konstantin, Greger, James G., Favorova, Olga, Merkel, George, Yen, Tim J., Katz, Richard A., Skalka, Anna Marie

“…Caffeine is an efficient inhibitor of cellular DNA repair, likely through its effects on ATM (ataxia telangiectasia mutated) and ATR (ATM and Rad3-related)…”
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Zwilch, a new component of the ZW10/ROD complex required for kinetochore functions by Williams, Byron C, Li, ZeXiao, Liu, Songtao, Williams, Erika V, Leung, Garmay, Yen, Tim J, Goldberg, Michael L

“…The Zeste-White 10 (ZW10) and Rough Deal (ROD) proteins are part of a complex necessary for accurate chromosome segregation. This complex recruits cytoplasmic…”
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