Search Results - "Yemma, Michael"

MiR-138 and MiR-135 directly target focal adhesion kinase, inhibit cell invasion, and increase sensitivity to chemotherapy in cancer cells by Golubovskaya, Vita M, Sumbler, Brittany, Ho, Baotran, Yemma, Michael, Cance, William G

“…Focal Adhesion Kinase is a 125 kDa non-receptor kinase and overexpressed in many types of tumors. Recently, short noncoding RNAs, called microRNAs have been…”
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Pharmacologic blockade of FAK autophosphorylation decreases human glioblastoma tumor growth and synergizes with temozolomide by Golubovskaya, Vita M, Huang, Grace, Ho, Baotran, Yemma, Michael, Morrison, Carl D, Lee, Jisook, Eliceiri, Brian P, Cance, William G

“…Malignant gliomas are characterized by aggressive tumor growth with a mean survival of 15 to 18 months and frequently developed resistance to temozolomide…”
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Abstract C211: Demonstration of the efficacy of compound CFAK-C4, Targeting FAK-VEGFR-3 protein-protein interaction in animal models of gastric cancer by Kurenova, Elena, Sanghera, Sartaj, Liao, Jian, Yemma, Michael, Cance, William

“…While the emerging data strongly suggests that FAK is an excellent target for developmental therapeutics of cancer, small molecule kinase inhibitors of FAK…”
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A small molecule focal adhesion kinase (FAK) inhibitor, targeting Y397 site: 1-(2-hydroxyethyl) -3, 5, 7-triaza-1-azoniatricyclo [3.3.1.13,7]decane; bromide effectively inhibits FAK autophosphorylation activity and decreases cancer cell viability, clonogenicity and tumor growth in vivo by GOLUBOVSKAYA, Vita M, FIGEL, Sheila, GELMAN, Irwin H, CANCE, William G, HO, Baotran T, JOHNSON, Christopher P, YEMMA, Michael, HUANG, Grace, MIN ZHENG, NYBERG, Carl, MAGIS, Andrew, OSTROV, David A

“…Focal adhesion kinase (FAK) is a protein tyrosine kinase that is overexpressed in most solid types of tumors and plays an important role in the survival…”
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A FAK scaffold inhibitor disrupts FAK and VEGFR-3 signaling and blocks melanoma growth by targeting both tumor and endothelial cells by Kurenova, Elena, Ucar, Deniz, Liao, Jianqun, Yemma, Michael, Gogate, Priyanka, Bshara, Wiam, Sunar, Ulas, Seshadri, Mukund, Hochwald, Steven N, Cance, William G

“…Melanoma has the highest mortality rate of all skin cancers and a major cause of treatment failure is drug resistance. Tumors heterogeneity requires novel…”
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Targeting the C-terminal focal adhesion kinase scaffold in pancreatic cancer by Gogate, Priyanka N, Kurenova, Elena V, Ethirajan, Manivannan, Liao, Jianqun, Yemma, Michael, Sen, Arindam, Pandey, Ravindra K, Cance, William G

“…Highlights • C-terminal FAK scaffold inhibitor C10 selectively targets cancer cells with high FAK-Y925 and VEGFR3 expression levels. • FAK inhibitor C10…”
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Demonstration of the efficacy of compound CFAK-C4 targeting FAK-VEGFR3 protein-protein interaction in gastric cancer by Kurenova, Elena V., Sanghera, Sartaj Singh, Liao, Jianqun, Yemma, Michael, Cance, William G.

“…Abstract only e22143 Background: While the emerging data strongly suggest that FAK is an excellent target for developmental therapeutics of cancer, kinase…”
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The FAK scaffold inhibitor C4 disrupts FAK-VEGFR-3 signaling and inhibits pancreatic cancer growth by Kurenova, Elena, Liao, Jianqun, He, Di-Hua, Hunt, Darrell, Yemma, Michael, Bshara, Wiam, Seshadri, Mukund, Cance, William G

“…Even with successful surgical resection and perioperative chemotherapy and radiation, pancreatic ductal adenocarcinoma (PDA) has a high incidence of…”
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Abstract B3: Anti-angiogenic properties of FAK-VEGFR3 scaffold inhibitors, C9 and C10 by Agharkar, Priyanka A., Ethirajan, Manivannan, Liao, Jianqun, Yemma, Michael, Buckley, Brian, Chernov, Mikhail, Cance, William, Pandey, Ravindra, Kurenova, Elena

“…Introduction: Focal adhesion kinase (FAK) and vascular endothelial growth factor receptor 3 (VEGFR3) are tyrosine kinases, which function as key modulators of…”
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Abstract A293: Novel allosteric small molecule FAK inhibitors effectively inhibit cancer cell viability and clonogenicity by Golubovskaya, Vita M., Lebedyeva, Iryna, Ho, Baotran, Yemma, Michael, Singh, Neha, Arcara, Makayla, Ostrov, David, Katritzky, Alan, Cance, William

“…Introduction: Focal Adhesion Kinase is overexpressed and activated in many types of tumors and plays an important role in survival. Recently, we developed FAK…”
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Abstract 3247: Novel small molecule inhibitors C9 and C10 specifically disrupt the FAK-VEGFR3 signaling axis in cancer cells by Agharkar, Priyanka A., Ethirajan, Manivannan, Magis, Andrew, Liao, Jian, Yemma, Michael, Cance, William, Pandey, Ravindra, Kurenova, Elena

“…Introduction: FAK functions as both, a critical signaling kinase and a scaffolding protein to collectively mediate proliferation, survival, cell adhesion and…”
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Abstract 3756: Structure activity relationship studies of novel FAK inhibitor C4 by Agharkar, Priyanka A., Ethirajan, Manivannan, Liao, Jianqun, Yemma, Michael, Cance, William, Pandey, Ravindra, Kurenova, Elena

“…Introduction: FAK and VEGFR3 have stirred considerable interest in recent years as attractive anti-cancer targets, owing to their high expression across…”
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Pharmacological blockade of FAK autophosphorylation decreases human glioblastoma tumor growth and synergizes with temozolomide by Golubovskaya, Vita M., Huang, Grace, Ho, Baotran, Yemma, Michael, Morrison, Carl D., Lee, Jisook, Eliceiri, Brian P., Cance, William G.

“…Malignant gliomas are characterized by aggressive tumor growth with a mean survival of 15–18 months and frequently developed resistance to temozolomide…”
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Abstract C191: Preclinical investigation of the antitumor efficacy in lung cancer of Y15, a novel focal adhesion kinase inhibitor by Dy, Grace K., Shao, Huanjie, Ho, Baotran, Yemma, Michael, Adjei, Alex, Golubovskaya, Vita, Cance, William

“…Introduction: Focal adhesion kinase (FAK) is a nonreceptor tyrosine kinase that associates with a number of cell adhesion components, such as integrins,…”
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Abstract B244: The small molecule focal adhesion kinase inhibitor Y15 decreases human glioblastoma cell viability, clonogenicity, and tumor growth by Golubovskaya, Vita M., Grace, Huang, Ho, Baotran, Yemma, Michael, Morrison, Carl, Song, Liu, Hu, Qiang, Cance, William

“…Introduction: Glioblastomas are the third most frequent cause of cancer-associated deaths due to the cancer cell rapid growth and high invasion and novel…”
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Abstract C124: Development of novel FAK inhibitors targeting the FAK-VEGFR3 protein-protein interaction site by Agharkar, Priyanka A., Ethirajan, Manivannan, Liao, Jianqun, Yemma, Michael, Magis, Andrew, Cance, William, Pandey, Ravindra, Kurenova, Elena

“…Introduction: FAK and VEGFR-3 have stirred considerable interest in recent years as attractive anti-cancer targets, owing to their high expression across…”
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