Search Results - "Yehl, Peter M."

A strategic approach towards mass balance investigations in pharmaceutical drug substance release testing: A peculiar out of specification case study encountered during API manufacture by Scott, Brandon S., Zhang, Kelly, Yehl, Peter M., Yang, Samuel H.

“…Mass balance in drug substances release testing is a critical quality attribute in pharmaceutical manufacturing that continues to challenge modern analytical…”
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Two-dimensional reversed phase-normal phase liquid chromatography for simultaneous achiral-chiral analysis to support high-throughput experimentation by Chin, Steven, Cruz, Karissa, Goyon, Alexandre, Venkatramani, Cadapakam J., Yehl, Peter M., Kurita, Kenji L.

“…•Development of a RPLCNPLC two-dimensional liquid chromatography system.•Simultaneous achiral-chiral analysis to support high-throughput…”
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Deep eutectic solvents as green and sustainable diluents in headspace gas chromatography for the determination of trace level genotoxic impurities in pharmaceuticals by Abbasi, Nabeel Mujtaba, Anderson, Jared L., Pellett, Jackson D., Yehl, Peter M., del Barrio, Mary-Anne, Zhong, Qiqing

“…Genotoxic impurities (GTIs) are potential carcinogens that need to be controlled down to ppm or lower concentration levels in pharmaceuticals under strict…”
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Determination of trace level genotoxic impurities in small molecule drug substances using conventional headspace gas chromatography with contemporary ionic liquid diluents and electron capture detection by Ho, Tien D., Yehl, Peter M., Chetwyn, Nik P., Wang, Jin, Anderson, Jared L., Zhong, Qiqing

“…•A novel methodology using ionic liquids as diluents for headspace GC.•Greatly broadening the applicability of headspace GC for high boiling…”
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Practical aspects of fast HPLC separations for pharmaceutical process development using monolithic columns by Wu, Naijun, Dempsey, Jillian, Yehl, Peter M., Dovletoglou, Angelos, Ellison, Dean, Wyvratt, Jean

“…A large number of samples can be generated during pharmaceutical process development. Fast separation for these samples is usually challenging due to the…”
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Deep eutectic solvents as green and sustainable diluents in headspace gas chromatography for the determination of trace level genotoxic impurities in pharmaceuticals by Abbasi, Nabeel Mujtaba, Anderson, Jared L., Pellett, Jackson D., Yehl, Peter M., del Barrio, Mary-Anne, Zhong, Qiqing

“…Genotoxic impurities (GTIs) are potential carcinogens that need to be controlled down to ppm or lower concentration levels in pharmaceuticals under strict…”
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Total synthesis of a second generation HIV protease inhibitor by Gauthier, Donald R., Ikemoto, Norihiro, Fleitz, Fred J., Szumigala, Ronald H., Petrillo, Dan, Liu, Jinchu, Reamer, Robert A., Armstrong, Joseph D., Yehl, Peter M., Wu, Naijun, Volante, R.P.

“…An efficient stereoselective preparation of HIV protease inhibitor (+)- 1 was synthesized on multi-kilogram scale in 16 steps without the use of…”
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