Assessment of The Role of Serum Neutrophil Gelatinase-Associated Lipocalin in Egyptian Childhood Bronchial Asthma: One Centre Study

Neutrophil gelatinase-associated lipocalin (NGAL) is emerging as a potential biomarker in many medical conditions including asthma. The aim of this study was to assess the role of serum NGAL in Egyptian childhood bronchial asthma. The study included 156 patients and 39 apparently healthy control chi...

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Bibliographic Details
Published in:	The Egyptian journal of immunology Vol. 27; no. 2; p. 93
Main Authors:	Allam, Ayman A, Naguib, Mohamed S, Hegazy, Mohamed S, Fouad, Ahmed M, Yehia, Shymaa, Morad, Emad A
Format:	Journal Article
Language:	English
Published:	Egypt 01-06-2020
Subjects:	Asthma - blood Asthma - diagnosis Biomarkers Child Egypt Humans Lipocalin-2 - blood ROC Curve Egypt
Online Access:	Get more information
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Summary:	Neutrophil gelatinase-associated lipocalin (NGAL) is emerging as a potential biomarker in many medical conditions including asthma. The aim of this study was to assess the role of serum NGAL in Egyptian childhood bronchial asthma. The study included 156 patients and 39 apparently healthy control children. Full clinical examination, pulmonary function tests; CBC, CRP, IgE, liver function tests, and renal function tests, and serum NGAL level were performed. The difference between the studied groups was statistically significant regarding IgE, eosinophils and NGAL (P= 0.001 for each). In addition, the difference between the subgroup with severe persistent asthma and the subgroup with mild intermittent asthma was significant (P=0.001). ROC curve analysis showed that at a cut-off value of 0.884 the sensitivity and specificity of differentiating severe bronchial asthma patients from controls was 82 % and 76 %, respectively. In conclusion, NGAL may represent a potential marker of bronchial asthma in children with severe disease.
ISSN:	1110-4902