Search Results - "Yeh, Christine Y"

A Conserved Local Structural Motif Controls the Kinetics of PTP1B Catalysis by Yeh, Christine Y., Izaguirre, Jesus A., Greisman, Jack B., Willmore, Lindsay, Maragakis, Paul, Shaw, David E.

“…Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator of the insulin and leptin signaling pathways, making it a highly attractive target for the…”
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Assessing biological and technological variability in protein levels measured in pre-diagnostic plasma samples of women with breast cancer by Yeh, Christine Y, Adusumilli, Ravali, Kullolli, Majlinda, Mallick, Parag, John, Esther M, Pitteri, Sharon J

“…Quantitative proteomics allows for the discovery and functional investigation of blood-based pre-diagnostic biomarkers for early cancer detection. However, a…”
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Discovery and Validation of the Binding Poses of Allosteric Fragment Hits to Protein Tyrosine Phosphatase 1b: From Molecular Dynamics Simulations to X‑ray Crystallography by Greisman, Jack B., Willmore, Lindsay, Yeh, Christine Y., Giordanetto, Fabrizio, Shahamadtar, Sahar, Nisonoff, Hunter, Maragakis, Paul, Shaw, David E.

“…Fragment-based drug discovery has led to six approved drugs, but the small sizes of the chemical fragments used in such methods typically result in only weak…”
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Vitamin D supplementation decreases serum 27-hydroxycholesterol in a pilot breast cancer trial by Going, Catherine C., Alexandrova, Ludmila, Lau, Kenneth, Yeh, Christine Y., Feldman, David, Pitteri, Sharon J.

“…Purpose 27-hydroxycholesterol (27HC), an endogenous selective estrogen receptor modulator (SERM), drives the growth of estrogen receptor-positive (ER+) breast…”
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A Conserved Local Structural Motif Controls the Kinetics of PTP1b Catalysis by Yeh, Christine Y., Izaguirre, Jesus, Greisman, Jack, Willmore, Lindsay, Maragakis, Paul, Shaw, David E.

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Integrative Personal Omics Profiles during Periods of Weight Gain and Loss by Piening, Brian D, Zhou, Wenyu, Contrepois, Kévin, Röst, Hannes, Gu Urban, Gucci Jijuan, Mishra, Tejaswini, Hanson, Blake M, Bautista, Eddy J, Leopold, Shana, Yeh, Christine Y, Spakowicz, Daniel, Banerjee, Imon, Chen, Cynthia, Kukurba, Kimberly, Perelman, Dalia, Craig, Colleen, Colbert, Elizabeth, Salins, Denis, Rego, Shannon, Lee, Sunjae, Zhang, Cheng, Wheeler, Jessica, Sailani, M Reza, Liang, Liang, Abbott, Charles, Gerstein, Mark, Mardinoglu, Adil, Smith, Ulf, Rubin, Daniel L, Pitteri, Sharon, Sodergren, Erica, McLaughlin, Tracey L, Weinstock, George M, Snyder, Michael P

“…Advances in omics technologies now allow an unprecedented level of phenotyping for human diseases, including obesity, in which individual responses to excess…”
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Abstract 1128: Lineage tracing of CAR T cells in patients with B cell malignancies by Good, Zinaida, Hamilton, Mark P., Spiegel, Jay Y., Kurra, Sreevidya, Desai, Moksha H., Prabhu, Snehit, Chiou, Shin-Heng, Yeh, Christine Y., Chen, Yiyun, Yang, Eric, Ozawa, Michael G., Wu, Fang, Frank, Matthew J., Muffly, Lori, Claire, Gursharan K., Craig, Juliana, Iglesias, Maria I., Bharadwaj, Sushma, Kong, Katherine A., Wagh, Dhananjay, Coller, John, Davis, Mark M., Plevritis, Sylvia K., Sahaf, Bita, Miklos, David B., Mackall, Crystal L.

“…Autologous T cells genetically engineered to express a chimeric antigen receptor (CAR) targeting CD19 and/or CD22 have achieved high complete response rates in…”
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