Search Results - "Yee, Ying K"

Identification and characterization of noncalcemic, tissue-selective, nonsecosteroidal vitamin D receptor modulators by Ma, Yanfei, Khalifa, Berket, Yee, Ying K, Lu, Jianfen, Memezawa, Ai, Savkur, Rajesh S, Yamamoto, Yoko, Chintalacharuvu, Subba R, Yamaoka, Kazuyoshi, Stayrook, Keith R, Bramlett, Kelli S, Zeng, Qing Q, Chandrasekhar, Srinivasan, Yu, Xiao-Peng, Linebarger, Jared H, Iturria, Stephen J, Burris, Thomas P, Kato, Shigeaki, Chin, William W, Nagpal, Sunil

“…Vitamin D receptor (VDR) ligands are therapeutic agents for the treatment of psoriasis, osteoporosis, and secondary hyperparathyroidism. VDR ligands also show…”
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Novel 3-Aryl Indoles as Progesterone Receptor Antagonists for Uterine Fibroids by Richardson, Timothy I, Clarke, Christian A, Yu, Kuo-Long, Yee, Ying K, Bleisch, Thomas J, Lopez, Jose E, Jones, Scott A, Hughes, Norman E, Muehl, Brian S, Lugar, Charles W, Moore, Terry L, Shetler, Pamela K, Zink, Richard W, Osborne, John J, Montrose-Rafizadeh, Chahrzad, Patel, Nita, Geiser, Andrew G, Galvin, Rachelle J. Sells, Dodge, Jeffrey A

“…We report the synthesis and characterization of novel 3-aryl indoles as potent and efficacious progesterone receptor (PR) antagonists with potential for the…”
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Vitamin D receptor modulators for inflammation and cancer by Yee, Ying K, Chintalacharuvu, Subba R, Lu, Jianfen, Nagpal, Sunil

“…1alpha, 25-Dihydroxyvitamin D3 [1,25-(OH)2D3], the biologically active form of vitamin D, is an important hormone that is critically required for the…”
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Vitamin D receptor as a drug discovery target by Pinette, Karen V, Yee, Ying K, Amegadzie, Bernard Y, Nagpal, Sunil

“…1alpha, 25-dihydroxyvitamin D3 [1,25 (OH)(2)D(3)], the active metabolite of vitamin D3, is known for the maintenance of normal skeleton architecture and…”
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Anthranilamide inhibitors of factor Xa by Mendel, David, Marquart, Angela L., Joseph, Sajan, Waid, Philip, Yee, Ying K., Tebbe, Anne Louise, Ratz, Andrew M., Herron, David K., Goodson, Theodore, Masters, John J., Franciskovich, Jeffry B., Tinsley, Jennifer M., Wiley, Michael R., Weir, Leonard C., Kyle, Jeffrey A., Klimkowski, Valentine J., Smith, Gerald F., Towner, Richard D., Froelich, Larry L., Buben, John, Craft, Trelia J.

“…SAR about the B-ring of N 2-aroyl anthranilamide 3e is described. B-ring o-aminoalkylethers and B-ring p-amine probes of the S1′ and S4 sites, respectively,…”
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A novel series of selective leukotriene antagonists: exploration and optimization of the acidic region in 1,6-disubstituted indoles and indazoles by Yee, Ying K, Bernstein, Peter R, Adams, Edward J, Brown, Frederick J, Cronk, Laura A, Hebbel, Kevin C, Vacek, Edward P, Krell, Robert D, Snyder, David W

“…A systematic structure-activity exploration of the carboxylic acid region in a series of indole- or indazole-derived leukotriene antagonists 1 led to several…”
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Evolution of a series of peptidoleukotriene antagonists: synthesis and structure-activity relationships of 1,6-disubstituted indoles and indazoles by Brown, Frederick J, Yee, Ying K, Cronk, Laura A, Hebbel, Kevin C, Krell, Robert D, Snyder, David W

“…A perception of structural similarities between two independent series of leukotriene antagonists (one emanating from FPL 55712 and one based upon the…”
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N 2-Aroylanthranilamide Inhibitors of Human Factor Xa by Yee, Ying K, Tebbe, Anne Louise, Linebarger, Jared H, Beight, Douglas W, Craft, Trelia J, Gifford-Moore, Donetta, Goodson, Theodore, Herron, David K, Klimkowski, Valentine J, Kyle, Jeffrey A, Sawyer, J. Scott, Smith, Gerald F, Tinsley, Jennifer M, Towner, Richard D, Weir, Leonard, Wiley, Michael R

“…Reversal of the A-ring amide link in 1,2-dibenzamidobenzene 1 (fXa K ass = 0.81 × 106 L/mol) led to a series of human factor Xa (hfXa) inhibitors based on N…”
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Non-Amidine-Containing 1,2-Dibenzamidobenzene Inhibitors of Human Factor Xa with Potent Anticoagulant and Antithrombotic Activity by Masters, John J, Franciskovich, Jeffry B, Tinsley, Jennifer M, Campbell, Charles, Campbell, Jack B, Craft, Trelia J, Froelich, Larry L, Gifford-Moore, Donetta S, Hay, Lynne A, Herron, David K, Klimkowski, Valentine J, Kurz, Kenneth D, Metz, James T, Ratz, Andrew M, Shuman, Robert T, Smith, Gerald F, Smith, Tommy, Towner, Richard D, Wiley, Michael R, Wilson, Alex, Yee, Ying K

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Conjugate and direct addition of ester enolates to cyclohexenone. Selective control of reaction composition by Schultz, Arthur G, Yee, Ying K

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Hydroxyacetophenone-derived antagonists of the peptidoleukotrienes by Brown, Frederick J, Bernstein, Peter R, Cronk, Laura A, Dosset, David L, Hebbel, Kevin C, Maduskuie, Thomas P, Shapiro, Howard S, Vacek, Edward P, Yee, Ying K

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Identification of Essential Residues for the Catalytic Function of 85-kDa Cytosolic Phospholipase A2 by Pickard, Richard T., Chiou, X. Grace, Strifler, Beth A., DeFelippis, Michael R., Hyslop, Paul A., Tebbe, Ann Louise, Yee, Ying K., Reynolds, Laure J., Dennis, Edward A., Kramer, Ruth M., Sharp, John D.

“…Cytosolic phospholipase A 2 (cPLA 2 ) hydrolyzes the sn -2-acyl ester bond of phospholipids and shows a preference for arachidonic acid-containing substrates…”
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Biochemical and pharmacological characterization of the binding of the selective peptide-leukotriene antagonist, 3H-ICI 198,615, to leukotriene D4 receptors in guinea-pig lung membranes by Aharony, D, Falcone, R C, Yee, Y K, Hesp, B, Giles, R E, Krell, R D

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Synthesis and in vitro LTD4 antagonist activity of bicyclic and monocyclic cyclopentylurethane and cyclopentylacetamide N-arylsulfonyl amides by Matassa, Victor G, Brown, Frederick J, Bernstein, Peter R, Shapiro, Howard S, Maduskuie, Thomas P, Cronk, Laura A, Vacek, Edward P, Yee, Ying K, Snyder, David W

“…The dissociation constants (KB) at the LTD4 receptor on guinea pig trachea of a series of monocyclic and bicyclic cyclopentylurethane and cyclopentylacetamide…”
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Studies directed at a synthesis of the morphine alkaloids. A photochemical approach by Schultz, Arthur G, Lucci, Robert D, Napier, James J, Kinoshita, Hideki, Ravichandran, Ramanathan, Shannon, Paul, Yee, Ying K

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Carbonyl transposition studies by Yee, Ying K, Schultz, Arthur G

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Total synthesis of dl-lycoramine by Schultz, Arthur G, Yee, Ying K, Berger, Mitchell H

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Identification of essential residues for the catalytic function of 85-kDa cytosolic phospholipase A2. Probing the role of histidine, aspartic acid, cysteine, and arginine by Pickard, R T, Chiou, X G, Strifler, B A, DeFelippis, M R, Hyslop, P A, Tebbe, A L, Yee, Y K, Reynolds, L J, Dennis, E A, Kramer, R M, Sharp, J D

“…Cytosolic phospholipase A2 (cPLA2) hydrolyzes the sn-2-acyl ester bond of phospholipids and shows a preference for arachidonic acid-containing substrates. We…”
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N(2)-Aroylanthranilamide inhibitors of human factor Xa by Yee, Y K, Tebbe, A L, Linebarger, J H, Beight, D W, Craft, T J, Gifford-Moore, D, Goodson, Jr, T, Herron, D K, Klimkowski, V J, Kyle, J A, Sawyer, J S, Smith, G F, Tinsley, J M, Towner, R D, Weir, L, Wiley, M R

“…Reversal of the A-ring amide link in 1,2-dibenzamidobenzene 1 (fXa K(ass) = 0.81 x 10(6) L/mol) led to a series of human factor Xa (hfXa) inhibitors based on…”
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The preclinical pharmacology of ICI 204,219. A peptide leukotriene antagonist by Krell, R D, Aharony, D, Buckner, C K, Keith, R A, Kusner, E J, Snyder, D W, Bernstein, P R, Matassa, V G, Yee, Y K, Brown, F J

“…ICI 204,219 (4-(5-cyclopentyloxycarbonylamino-1-methylindol-3-ylmethy l)-3- methoxy-N-o-tolylsulfonylbenzamide) was designed as a peptide leukotriene (LT)…”
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