Search Results - "Yee, Vivien C."

Structural Basis of Substrate Recognition in Human Nicotinamide N-Methyltransferase by Peng, Yi, Sartini, Davide, Pozzi, Valentina, Wilk, Dennis, Emanuelli, Monica, Yee, Vivien C

“…Nicotinamide N-methyltransferase (NNMT) catalyzes the N-methylation of nicotinamide, pyridines, and other analogues using S-adenosyl-l-methionine as donor…”
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Crystal structure of the human prion protein reveals a mechanism for oligomerization by Yee, Vivien C, Knaus, Karen J, Morillas, Manuel, Swietnicki, Wieslaw, Malone, Michael, Surewicz, Witold K

“…The pathogenesis of transmissible encephalopathies is associated with the conversion of the cellular prion protein, PrPC, into a conformationally altered…”
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Bora downregulation results in radioresistance by promoting repair of double strand breaks by Cairns, Junmei, Peng, Yi, Yee, Vivien C, Lou, Zhenkun, Wang, Liewei

“…Following DNA double-strand breaks cells activate several DNA-damage response protein kinases, which then trigger histone H2AX phosphorylation and the…”
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Crystal Structure of the 2′-Specific and Double-Stranded RNA-Activated Interferon-Induced Antiviral Protein 2′-5′-Oligoadenylate Synthetase by Hartmann, Rune, Justesen, Just, Sarkar, Saumendra N, Sen, Ganes C, Yee, Vivien C

“…2′-5′-oligoadenylate synthetases are interferon-induced, double-stranded RNA-activated antiviral enzymes which are the only proteins known to catalyze…”
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Crystal Structure of the Deglycating Enzyme Fructosamine Oxidase (Amadoriase II) by Collard, François, Zhang, Jianye, Nemet, Ina, Qanungo, Kaustubha R., Monnier, Vincent M., Yee, Vivien C.

“…Fructosamine oxidases (FAOX) catalyze the oxidative deglycation of low molecular weight fructosamines (Amadori products). These proteins are of interest in…”
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Cytosolic 5′-nucleotidase III (NT5C3): gene sequence variation and functional genomics by Aksoy, Pinar, Zhu, Min Jia, Kalari, Krishna R, Moon, Irene, Pelleymounter, Linda L, Eckloff, Bruce W, Wieben, Eric D, Yee, Vivien C, Weinshilboum, Richard M, Wang, Liewei

“…BACKGROUND5′-Nucleotidases play a critical role in nucleotide pool balance and in the metabolism of nucleoside analogs such as gemcitabine and cytosine…”
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Impaired dimer assembly and decreased stability of naturally recurring R260C mutant A subunit for coagulation factor XIII by Maeda, Shoko, Zhang, Wei Guang, Souri, Masayoshi, Yee, Vivien C, Ichinose, Akitada

“…Factor XIII (FXIII) consists of catalytic A subunits (FXIII-A) and carrier B subunits. Congenital FXIII deficiency is a severe bleeding disorder. We previously…”
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Characterization of Four Variant Forms of Human Propionyl-CoA Carboxylase Expressed in Escherichia coli by Jiang, Hua, Rao, K. Sudhindra, Yee, Vivien C., Kraus, Jan P.

“…Propionyl-CoA carboxylase (PCC) is a biotin-dependent mitochondrial enzyme that catalyzes the conversion of propionyl-CoA to d-methylmalonyl-CoA. PCC consists…”
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Structure of the dimerized hormone-binding domain of a guanylyl- cyclase-coupled receptor by Miyagi, Masaru, van den Akker, Focco, Zhang, Xiaolun, Yee, Vivien C, Huo, Xuewen, Misono, Kunio S

“…The atrial natriuretic peptide (ANP) hormone is secreted by the heart in response to an increase in blood pressure. ANP exhibits several potent…”
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Crystal Structures of Polymorphic Prion Protein β1 Peptides Reveal Variable Steric Zipper Conformations by Yu, Lu, Lee, Seung-Joo, Yee, Vivien C

“…The pathogenesis of prion diseases is associated with the conformational conversion of normal, predominantly α-helical prion protein (PrPC) into a pathogenic…”
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An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein by Glidden, Michael D., Aldabbagh, Khadijah, Phillips, Nelson B., Carr, Kelley, Chen, Yen-Shan, Whittaker, Jonathan, Phillips, Manijeh, Wickramasinghe, Nalinda P., Rege, Nischay, Swain, Mamuni, Peng, Yi, Yang, Yanwu, Lawrence, Michael C., Yee, Vivien C., Ismail-Beigi, Faramarz, Weiss, Michael A.

“…Thermal degradation of insulin complicates its delivery and use. Previous efforts to engineer ultra-stable analogs were confounded by prolonged cellular…”
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Structure-based stabilization of insulin as a therapeutic protein assembly via enhanced aromatic–aromatic interactions by Rege, Nischay K., Wickramasinghe, Nalinda P., Tustan, Alisar N., Phillips, Nelson F.B., Yee, Vivien C., Ismail-Beigi, Faramarz, Weiss, Michael A.

“…Key contributions to protein structure and stability are provided by weakly polar interactions, which arise from asymmetric electronic distributions within…”
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Conformational diversity in prion protein variants influences intermolecular β-sheet formation by Lee, Seungjoo, Antony, Lizamma, Hartmann, Rune, Knaus, Karen J, Surewicz, Krystyna, Surewicz, Witold K, Yee, Vivien C

“…A conformational transition of normal cellular prion protein (PrP C ) to its pathogenic form (PrP Sc ) is believed to be a central event in the transmission of…”
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The Dual Regulatory Role of Amino Acids Leu480 and Gln481 of Prothrombin by Wiencek, Joesph R., Hirbawi, Jamila, Yee, Vivien C., Kalafatis, Michael

“…Prothrombin (FII) is activated to α-thrombin (IIa) by prothrombinase. Prothrombinase is composed of a catalytic subunit, factor Xa (fXa), and a regulatory…”
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Targeting Bcl-2 based on the interaction of its BH4 domain with the inositol 1,4,5-trisphosphate receptor by Rong, Yi-Ping, Barr, Paul, Yee, Vivien C., Distelhorst, Clark W.

“…Bcl-2 is the founding member of a large family of apoptosis regulating proteins. Bcl-2 is a prime target for novel therapeutics because it is elevated in many…”
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Aggresome formation and pharmacogenetics: sulfotransferase 1A3 as a model system by Wang, Liewei, Yee, Vivien C., Weinshilboum, Richard M.

“…A common cause for pharmacogenetic alteration in drug response is genetic variation in encoded amino acid sequence. We have used the catecholamine and…”
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A chimeric prokaryotic pentameric ligand-gated channel reveals distinct pathways of activation by Schmandt, Nicolaus, Velisetty, Phanindra, Chalamalasetti, Sreevatsa V, Stein, Richard A, Bonner, Ross, Talley, Lauren, Parker, Mark D, Mchaourab, Hassane S, Yee, Vivien C, Lodowski, David T, Chakrapani, Sudha

“…Recent high resolution structures of several pentameric ligand-gated ion channels have provided unprecedented details of their molecular architecture. However,…”
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Thiopurine S-methyltransferase pharmacogenetics: variant allele functional and comparative genomics by Salavaggione, Oreste E, Wang, Liewei, Wiepert, Mathieu, Yee, Vivien C, Weinshilboum, Richard M

“…Thiopurine S-methyltransferase (TPMT) catalyses the S-methylation of thiopurine drugs. Genetic polymorphisms for TPMT are a major factor responsible for large…”
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Residues required for phosphorylation of translation initiation factor eIF2α under diverse stress conditions are divergent between yeast and human by Majumder, Mithu, Mitchell, Daniel, Merkulov, Sergei, Wu, Jing, Guan, Bo-Jhih, Snider, Martin D., Krokowski, Dawid, Yee, Vivien C., Hatzoglou, Maria

“…•eIF2α phosphorylation is the master signal of the cellular response to stress.•Four stress-activated kinases phosphorylate eIF2α on Ser51.•Phosphorylation…”
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Molecular modeling predicts structural changes in the A subunit of factor XIII caused by two novel mutations identified in a neonate with severe congenital factor XIII deficiency by Souri, Masayoshi, Yee, Vivien C, Fujii, Noriko, Ichinose, Akitada

“…Abstract Introduction Coagulation factor XIII (FXIII) is a fibrin-stabilizing factor, which contributes to hemostasis, wound healing, and maintenance of…”
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