Search Results - "Yee, L K"

A phase I II study of imatinib plus reinduction therapy for c-kit-positive relapsed refractory acute myeloid leukemia: inhibition of Akt activation correlates with complete response by Brandwein, J M, Hedley, D W, Chow, S, Schimmer, A D, Yee, K W L, Schuh, A C, Gupta, V, Xu, W, Kamel-Reid, S, Minden, M D

“…This phase I/II study evaluated imatinib as a c-kit inhibitor combined with mitoxantrone, etoposide and cytarabine therapy for patients with primary refractory…”
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A phase I study of tipifarnib combined with conventional induction and consolidation therapy for previously untreated patients with acute myeloid leukemia aged 60 years and over by Brandwein, J M, Leber, B F, Howson-Jan, K, Schimmer, A D, Schuh, A C, Gupta, V, Yee, K W L, Wright, J, Moore, M, MacAlpine, K, Minden, M D

“…Patients aged 60 years and over with previously untreated acute myeloid leukemia were enrolled in a Phase I study combining tipifarnib with standard induction…”
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Venous thromboembolism prevention during asparaginase-based therapy for acute lymphoblastic leukemia by Sibai, H, Seki, J T, Wang, T Q, Sakurai, N, Atenafu, E G, Yee, K W L, Schuh, A C, Gupta, V, Minden, M D, Schimmer, A D, Brandwein, J M

“…Venous thromboembolism (vte) is a recognized complication in patients treated with asparaginase-containing chemotherapy regimens; the optimal preventive…”
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Transrepression activity of T-box1 in a gene regulation network in mouse cells by Yee, Karen K.L., Yagi, Hisato, Matsuoka, Rumiko, Nakanishi, Toshio, Furukawa, Toru

“…T-box1 (TBX1) has been identified as a candidate disease-causing gene in DiGeorge syndrome/conotruncal anomaly face syndrome (DGS/CAFS). Tbx1 can function as a…”
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Integrin-mediated signalling through the MAP-kinase pathway by Yee, K L, Weaver, V M, Hammer, D A

“…The mitogen activated protein (MAP) kinase cascade, leading to extracellular-regulated kinase (ERK) activation, is a key regulator of cell growth and…”
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Improving the efficiency of discrete time scheduling formulation by Yee, K.L., Shah, N.

“…The problem of production scheduling in multipurpose plants can be formulated as a mixed integer linear programming (MILP) problem based on a discrete…”
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High Inter- and Intrapatient Variation in 5-Fluorouracil Plasma Concentrations during a Prolonged Drug Infusion by TAKIMOTO, C. H, YEE, L. K, VENZON, D. J, SCHULER, B, GROLLMAN, F, CHABUK, C, HAMILTON, J. M, CHEN, A. P, ALLEGRA, C. J, GREM, J. L

“…The purpose of the study was to examine inter- and intrapatient variation in 5-fluorouracil (5-FU) plasma concentrations in adult cancer patients receiving a…”
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N-(phosphonacetyl)-L-aspartate and calcium leucovorin modulation of fluorouracil administered by constant rate and circadian pattern of infusion over 72 hours in metastatic gastrointestinal adenocarcinoma by Grem, J. L., Yee, L. K., Schuler, B., Hamilton, J. M., Chen, A. P., Chabuk, C., Grollman, F., Grabenc, M., Allegra, C. J., Takimoto, C. H.

“…Summary Background- We have reported that N-(phosphonacetyl)-L-aspartic acid (PALA) 1266 mg/m2 can safely be given 24 hours prior to the start of a 72-hour…”
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Scheduling of Multistage Fast-Moving Consumer Goods Plants by Yee, K. L., Shah, N.

“…Fast-moving consumer goods (FMCG) plants are required to be highly flexible due to their multiproduct nature and frequent portfolio changes with seasons or…”
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Inter- and intraindividual variation in dihydropyrimidine dehydrogenase activity in peripheral blood mononuclear cells by GREM, J. L, YEE, L. K, VENZON, D. J, TAKIMOTO, C. H, ALLEGRA, C. J

“…The activity of dihydropyrimidine dehydrogenase (DPD), the rate-limiting enzyme in fluorouracil catabolism, has been reported to vary according to time of day…”
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Metabolism and RNA incorporation of cyclopentenyl cytosine in human colorectal cancer cells by Yee, L K, Allegra, C J, Trepel, J B, Grem, J L

“…We studied the cytotoxicity and metabolism of the investigational cytidine analogue cyclopentenyl cytosine (CPE-C) in three human colorectal cancer cell lines:…”
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The prognostic impact of FLT3-ITD and NPM1 mutations in patients with relapsed acute myeloid leukemia and intermediate-risk cytogenetics by How, J, Sykes, J, Minden, M D, Gupta, V, Yee, K W L, Schimmer, A D, Schuh, A C, Kamel-Reid, S, Brandwein, J M

“…Internal tandem duplication of the fms-like tyrosine kinase-3 gene ( FLT3- ITD) and nucleophosmin-1 ( NPM1 ) mutations have prognostic importance in acute…”
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Scheduling of multistage fast-moving consumer goods plants by Yee, K L, Shah, N

“…Fast-moving consumer goods (FMCG) plants are required to be highly flexible due to their multiproduct nature and frequent portfolio changes with seasons or…”
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Coated piezoelectric quartz crystal monitor for determination of propylene glycol dinitrate vapor levels by Turnham, B. D, Yee, L. K, Luoma, G. A

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Determination of microgram amounts of asbestos in mixtures by infrared spectrometry by Luoma, G. A, Yee, L. K, Rowland, R

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POSB314 Method of Predicting Serotype Specific Effectiveness Against Invasive Pneumococcal Disease for Pneumococcal Conjugate Vaccines in Infant Population by Ryman, J, Yee, KL, Weaver, J, Hu, T, Sachs, J

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Decreased catabolism of fluorouracil in peripheral blood mononuclear cells during combination therapy with fluorouracil, leucovorin, and interferon alpha-2a by Yee, L K, Allegra, C J, Steinberg, S M, Grem, J L

“…We previously reported that recombinant interferon alpha-2a (IFN alpha-2a) therapy was associated with a dose-dependent decrease in fluorouracil (5-FU)…”
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Drug–Drug Interaction Studies: Regulatory Guidance and An Industry Perspective by Prueksaritanont, Thomayant, Chu, Xiaoyan, Gibson, Christopher, Cui, Donghui, Yee, Ka Lai, Ballard, Jeanine, Cabalu, Tamara, Hochman, Jerome

“…Recently, the US Food and Drug Administration and European Medicines Agency have issued new guidance for industry on drug interaction studies, which outline…”
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Genetic variability in Macadamia by Aradhya, M.K. (Hawaii Univ., Honolulu, HI (USA). Dept. of Horticulture), Yee, L.K, Zee, F.T, Manshardt, R.M

“…A genetic variability analysis involving 45 accessions of Macadamia including four species, M. integrifolia, M. tetraphylla, M. ternifolia, and M. hildebrandii…”
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Population Pharmacokinetics and Pharmacodynamics of Bezlotoxumab in Adults with Primary and Recurrent Clostridium difficile Infection by Yee, Ka Lai, Kleijn, Huub Jan, Kerbusch, Thomas, Matthews, Randolph P, Dorr, Mary Beth, Garey, Kevin W, Wrishko, Rebecca E

“…The fully human monoclonal antibody bezlotoxumab is indicated for preventing the recurrence of (formerly ) infection (CDI) in adults who receive antibacterial…”
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