Search Results - "Yechoor, Vijay K"

TEAD1 regulates cell proliferation through a pocket-independent transcription repression mechanism by Li, Feng, Negi, Vinny, Yang, Ping, Lee, Jeongkyung, Ma, Ke, Moulik, Mousumi, Yechoor, Vijay K

“…The Hippo-TEAD pathway regulates cellular proliferation and function. The existing paradigm is that TEAD co-activators, YAP and TAZ, and co-repressor, VGLL4,…”
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Tead1 is required for perinatal cardiomyocyte proliferation by Liu, Ruya, Jagannathan, Rajaganapathi, Li, Feng, Lee, Jeongkyung, Balasubramanyam, Nikhil, Kim, Byung S, Yang, Ping, Yechoor, Vijay K, Moulik, Mousumi

“…Adult heart size is determined predominantly by the cardiomyocyte number and size. The cardiomyocyte number is determined primarily in the embryonic and…”
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Bmal1 and β-Cell Clock Are Required for Adaptation to Circadian Disruption, and Their Loss of Function Leads to Oxidative Stress-Induced β-Cell Failure in Mice by Lee, Jeongkyung, Moulik, Mousumi, Fang, Zhe, Saha, Pradip, Zou, Fang, Xu, Yong, Nelson, David L., Ma, Ke, Moore, David D., Yechoor, Vijay K.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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VGLL4 and MENIN function as TEAD1 corepressors to block pancreatic β cell proliferation by Li, Feng, Liu, Ruya, Negi, Vinny, Yang, Ping, Lee, Jeongkyung, Jagannathan, Rajaganapathi, Moulik, Mousumi, Yechoor, Vijay K.

“…TEAD1 and the mammalian Hippo pathway regulate cellular proliferation and function, though their regulatory function in β cells remains poorly characterized…”
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Dopamine regulates pancreatic glucagon and insulin secretion via adrenergic and dopaminergic receptors by Aslanoglou, Despoina, Bertera, Suzanne, Sánchez-Soto, Marta, Benjamin Free, R., Lee, Jeongkyung, Zong, Wei, Xue, Xiangning, Shrestha, Shristi, Brissova, Marcela, Logan, Ryan W., Wollheim, Claes B., Trucco, Massimo, Yechoor, Vijay K., Sibley, David R., Bottino, Rita, Freyberg, Zachary

“…Dopamine (DA) and norepinephrine (NE) are catecholamines primarily studied in the central nervous system that also act in the pancreas as peripheral regulators…”
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Lipid droplet-associated hydrolase mobilizes stores of liver X receptor sterol ligands and protects against atherosclerosis by Goo, Young-Hwa, Plakkal Ayyappan, Janeesh, Cheeran, Francis D., Bangru, Sushant, Saha, Pradip K., Baar, Paula, Schulz, Sabine, Lydic, Todd A., Spengler, Bernhard, Wagner, Andreas H., Kalsotra, Auinash, Yechoor, Vijay K., Paul, Antoni

“…Foam cells in atheroma are engorged with lipid droplets (LDs) that contain esters of regulatory lipids whose metabolism remains poorly understood…”
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Author Correction: The Nuclear Receptor and Clock Repressor Rev-erbα Suppresses Myogenesis by Chatterjee, Somik, Yin, Hongshan, Li, Weini, Lee, Jeongkyung, Yechoor, Vijay K., Ma, Ke

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Brain and muscle Arnt-like 1 is a key regulator of myogenesis by Chatterjee, Somik, Nam, Deokhwa, Guo, Bingyan, Kim, Ji M, Winnier, Glen E, Lee, Jeongkyung, Berdeaux, Rebecca, Yechoor, Vijay K, Ma, Ke

“…The circadian clock network is an evolutionarily conserved mechanism that imparts temporal regulation to diverse biological processes. Brain and muscle…”
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Deficiency of Adipose Differentiation-Related Protein Impairs Foam Cell Formation and Protects Against Atherosclerosis by Paul, Antoni, Chang, Benny Hung-Junn, Li, Lan, Yechoor, Vijay K, Chan, Lawrence

“…Foam cells are a hallmark of atherosclerosis. However, it is unclear whether foam cell formation per se protects against atherosclerosis or fuels it. In this…”
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Obestatin stimulates glucose-induced insulin secretion through ghrelin receptor GHS-R by Pradhan, Geetali, Wu, Chia-Shan, Han Lee, Jong, Kanikarla, Preeti, Guo, Shaodong, Yechoor, Vijay K., Samson, Susan L., Sun, Yuxiang

“…Orexigenic hormone ghrelin and anorexic hormone obestatin are encoded by the same preproghrelin gene. While it is known that ghrelin inhibits…”
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The Human Lipodystrophy Gene Product Berardinelli-Seip Congenital Lipodystrophy 2/Seipin Plays a Key Role in Adipocyte Differentiation by Chen, Weiqin, Yechoor, Vijay K, Chang, Benny Hung-Junn, Li, Ming V, March, Keith L, Chan, Lawrence

“…Mutations in the Berardinelli-Seip congenital lipodystrophy 2 gene (BSCL2) are the underlying defect in patients with congenital generalized lipodystrophy type…”
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Light-Dark Patterns Mirroring Shift Work Accelerate Atherosclerosis and Promote Vulnerable Lesion Phenotypes by Figueiro, Mariana G, Goo, Young-Hwa, Hogan, Ryan, Plitnick, Barbara, Lee, Jeong-Kyung, Jahangir, Kiran, Moulik, Mousumi, Yechoor, Vijay K, Paul, Antoni

“…Background Despite compelling epidemiological evidence that circadian disruption inherent to long-term shift work enhances atherosclerosis progression and…”
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Effects of CaMKII-mediated phosphorylation of ryanodine receptor type 2 on islet calcium handling, insulin secretion, and glucose tolerance by Dixit, Sayali S, Wang, Tiannan, Manzano, Eiffel John Q, Yoo, Shin, Lee, Jeongkyung, Chiang, David Y, Ryan, Nicole, Respress, Jonathan L, Yechoor, Vijay K, Wehrens, Xander H T

“…Altered insulin secretion contributes to the pathogenesis of type 2 diabetes. This alteration is correlated with altered intracellular Ca(2+)-handling in…”
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Bromodomain Protein Inhibition Protects β-Cells from Cytokine-Induced Death and Dysfunction via Antagonism of NF-κB Pathway by Negi, Vinny, Lee, Jeongkyung, Mandi, Varun, Danvers, Joseph, Liu, Ruya, Perez-Garcia, Eliana M, Li, Feng, Jagannathan, Rajaganapati, Yang, Ping, Filingeri, Domenic, Kumar, Amit, Ma, Ke, Moulik, Mousumi, Yechoor, Vijay K

“…Cytokine-induced β-cell apoptosis is a major pathogenic mechanism in type 1 diabetes (T1D). Despite significant advances in understanding its underlying…”
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A metabolic dysfunction-associated steatotic liver acinus biomimetic induces pancreatic islet dysfunction in a coupled microphysiology system by Aleman, Julio, K, Ravikumar, Wiegand, Connor, Schurdak, Mark E., Vernetti, Lawrence, Gavlock, Dillon, Reese, Celeste, DeBiasio, Richard, LaRocca, Greg, Angarita, Yulder Daniel, Gough, Albert, Soto-Gutierrez, Alejandro, Behari, Jaideep, Yechoor, Vijay K., Miedel, Mark T., Stern, Andrew M., Banerjee, Ipsita, Taylor, D. Lansing

“…Preclinical and clinical studies suggest that lipid-induced hepatic insulin resistance is a primary defect that predisposes to dysfunction in islets,…”
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Transcriptional Profiling of Foam Cells Reveals Induction of Guanylate‐Binding Proteins Following Western Diet Acceleration of Atherosclerosis in the Absence of Global Changes in Inflammation by Goo, Young‐Hwa, Son, Se‐Hee, Yechoor, Vijay K., Paul, Antoni

“…Background Foam cells are central to two major pathogenic processes in atherogenesis: cholesterol buildup in arteries and inflammation. The main underlying…”
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Loss of Bmal1 leads to uncoupling and impaired glucose-stimulated insulin secretion in β-cells by Lee, Jeongkyung, Kim, Mi-Sun, Li, Rongying, Liu, Victoria Y., Fu, Loning, Moore, David D., Ma, Ke, Yechoor, Vijay K.

“…The circadian clock has been shown to regulate metabolic homeostasis. Mice with a deletion of Bmal1, a key component of the core molecular clock, develop…”
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Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin by Kahn, C. Ronald, Tseng, Yu-Hua, Butte, Atul J, Kokkotou, Efi, Yechoor, Vijay K, Taniguchi, Cullen M, Kriauciunas, Kristina M, Cypess, Aaron M, Niinobe, Michio, Yoshikawa, Kazuaki, Patti, Mary Elizabeth

“…The insulin/IGF-1 (insulin-like growth factor 1) signalling pathway promotes adipocyte differentiation via complex signalling networks. Here, using microarray…”
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Dual pancreatic adrenergic and dopaminergic signaling as a therapeutic target of bromocriptine by Aslanoglou, Despoina, Bertera, Suzanne, Friggeri, Laura, Sánchez-Soto, Marta, Lee, Jeongkyung, Xue, Xiangning, Logan, Ryan W., Lane, J. Robert, Yechoor, Vijay K., McCormick, Peter J., Meiler, Jens, Free, R. Benjamin, Sibley, David R., Bottino, Rita, Freyberg, Zachary

“…Bromocriptine is approved as a diabetes therapy, yet its therapeutic mechanisms remain unclear. Though bromocriptine’s actions have been mainly attributed to…”
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A Quantitative Systems Pharmacology Platform Reveals NAFLD Pathophysiological States and Targeting Strategies by Lefever, Daniel E, Miedel, Mark T, Pei, Fen, DiStefano, Johanna K, Debiasio, Richard, Shun, Tong Ying, Saydmohammed, Manush, Chikina, Maria, Vernetti, Lawrence A, Soto-Gutierrez, Alejandro, Monga, Satdarshan P, Bataller, Ramon, Behari, Jaideep, Yechoor, Vijay K, Bahar, Ivet, Gough, Albert, Stern, Andrew M, Taylor, D Lansing

“…Non-alcoholic fatty liver disease (NAFLD) has a high global prevalence with a heterogeneous and complex pathophysiology that presents barriers to traditional…”
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