Can anticarbamylated protein antibodies be used to support the diagnosis of systemic lupus erythematosus?

Autoantibody development plays an important role in the pathogenesis of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). In this study, we aimed to determine the diagnostic value of anticarbamylated protein antibody (anti-CarP) antibody in SLE and RA patients and its relationship wi...

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Published in:	Biomarkers in medicine Vol. 15; no. 14; pp. 1253 - 1260
Main Authors:	Özdemir, Bahar, Erden, Abdulsamet, Erten, Şükran, Yeşil, Turan H, Alışık, Murat, Kucuksahin, Orhan
Format:	Journal Article
Language:	English
Published:	England Future Medicine Ltd 01-10-2021
Subjects:	Adult anti-CarP antibody Arthritis, Rheumatoid - diagnosis Arthritis, Rheumatoid - metabolism Autoantibodies - metabolism Case-Control Studies Female Humans Lupus Erythematosus, Systemic - diagnosis Lupus Erythematosus, Systemic - metabolism Male Middle Aged Protein Carbamylation - physiology Proteins - metabolism rheumatoid arthritis systemic lupus erythematosus rheumatoid arthritis systemic lupus erythematosus anti-CarP antibody
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Summary:	Autoantibody development plays an important role in the pathogenesis of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). In this study, we aimed to determine the diagnostic value of anticarbamylated protein antibody (anti-CarP) antibody in SLE and RA patients and its relationship with disease prognosis. Fifty-seven SLE patients (F/M 50/7; median age 40.9 ± 13.7; median disease duration 2 years) who met the 2012 SLICC SLE diagnostic criteria were included in the study. A total of 46 RA patients selected according to the 2010 ACR/EULAR diagnostic criteria (F/M 38/8; median age 54.2 ± 12.4; median disease duration 2 years) were included. A total of 30 healthy individuals were selected as the control group. The anti-CarP antibody was studied by using human anticarbamylated protein antibody ELISA Kit (SunRedBio, Shanghai, China). Anti-CarP antibody positivity was found to be 17.4% in RA patients (p < 0.001), 54.4% in SLE patients (p < 0.001) and 3.3% in the healthy control group. The anti-CarP antibody was determined to predict SLE patients with 54.4% sensitivity and 96.7% specificity compared with the healthy control group (area under the curve: 0.755; p < 0.001). Anti-CarP antibody positivity was significantly higher in the SLE patients compared with the healthy control and RA group. It has significant sensitivity and specificity in both SLE and RA patients compared with the healthy controls.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1752-0363 1752-0371
DOI:	10.2217/bmm-2021-0037