Search Results - "Ye, Xiang S"

A novel CDK9 inhibitor shows potent antitumor efficacy in preclinical hematologic tumor models by Yin, Tinggui, Lallena, Maria J, Kreklau, Emiko L, Fales, Kevin R, Carballares, Santiago, Torrres, Raquel, Wishart, Graham N, Ajamie, Rose T, Cronier, Damien M, Iversen, Phillip W, Meier, Timothy I, Foreman, Robert T, Zeckner, Douglas, Sissons, Sean E, Halstead, Bart W, Lin, Aimee B, Donoho, Gregory P, Qian, Yuewei, Li, Shuyu, Wu, Song, Aggarwal, Amit, Ye, Xiang S, Starling, James J, Gaynor, Richard B, de Dios, Alfonso, Du, Jian

“…DNA-dependent RNA polymerase II (RNAP II) largest subunit RPB1 C-terminal domain (CTD) kinases, including CDK9, are serine/threonine kinases known to regulate…”
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Genomic alterations and molecular subtypes of gastric cancers in Asians by Ye, Xiang S, Yu, Chunping, Aggarwal, Amit, Reinhard, Christoph

“…Gastric cancer (GC) is a highly heterogenic disease, and it is the second leading cause of cancer death in the world. Common chemotherapies are not very…”
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p38 Mitogen-Activated Protein Kinase Promotes Cell Survival in Response to DNA Damage but Is Not Required for the G2 DNA Damage Checkpoint in Human Cancer Cells by Phong, Mark S., Van Horn, Robert D., Li, Shuyu, Tucker-Kellogg, Gregory, Surana, Uttam, Ye, Xiang S.

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Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes by Cristescu, Razvan, Lee, Jeeyun, Nebozhyn, Michael, Kim, Kyoung-Mee, Ting, Jason C, Wong, Swee Seong, Liu, Jiangang, Yue, Yong Gang, Wang, Jian, Yu, Kun, Ye, Xiang S, Do, In-Gu, Liu, Shawn, Gong, Lara, Fu, Jake, Jin, Jason Gang, Choi, Min Gew, Sohn, Tae Sung, Lee, Joon Ho, Bae, Jae Moon, Kim, Seung Tae, Park, Se Hoon, Sohn, Insuk, Jung, Sin-Ho, Tan, Patrick, Chen, Ronghua, Hardwick, James, Kang, Won Ki, Ayers, Mark, Hongyue, Dai, Reinhard, Christoph, Loboda, Andrey, Kim, Sung, Aggarwal, Amit

“…By using gene expression data, gastric cancer is divided into subtypes associated with distinct molecular alterations and clinical prognosis. Gastric cancer, a…”
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Induction of Apoptosis by Sphingoid Long-Chain Bases in Aspergillus nidulans by Cheng, Jijun, Park, Tae-Sik, Chio, Li-Chun, Fischl, Anthony S., Ye, Xiang S.

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The Genomic Landscape of Intrinsic and Acquired Resistance to Cyclin-Dependent Kinase 4/6 Inhibitors in Patients with Hormone Receptor-Positive Metastatic Breast Cancer by Wander, Seth A, Cohen, Ofir, Gong, Xueqian, Johnson, Gabriela N, Buendia-Buendia, Jorge E, Lloyd, Maxwell R, Kim, Dewey, Luo, Flora, Mao, Pingping, Helvie, Karla, Kowalski, Kailey J, Nayar, Utthara, Waks, Adrienne G, Parsons, Stephen H, Martinez, Ricardo, Litchfield, Lacey M, Ye, Xiang S, Yu, Chunping, Jansen, Valerie M, Stille, John R, Smith, Patricia S, Oakley, Gerard J, Chu, Quincy S, Batist, Gerald, Hughes, Melissa E, Kremer, Jill D, Garraway, Levi A, Winer, Eric P, Tolaney, Sara M, Lin, Nancy U, Buchanan, Sean G, Wagle, Nikhil

“…Mechanisms driving resistance to cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) in hormone receptor-positive (HR ) breast cancer have not been clearly…”
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Genomic Aberrations that Activate D-type Cyclins Are Associated with Enhanced Sensitivity to the CDK4 and CDK6 Inhibitor Abemaciclib by Gong, Xueqian, Litchfield, Lacey M., Webster, Yue, Chio, Li-Chun, Wong, Swee Seong, Stewart, Trent R., Dowless, Michele, Dempsey, Jack, Zeng, Yi, Torres, Raquel, Boehnke, Karsten, Mur, Cecilia, Marugán, Carlos, Baquero, Carmen, Yu, Chunping, Bray, Steven M., Wulur, Isabella H., Bi, Chen, Chu, Shaoyou, Qian, Hui-Rong, Iversen, Philip W., Merzoug, Farhana F., Ye, Xiang S., Reinhard, Christoph, De Dios, Alfonso, Du, Jian, Caldwell, Charles W., Lallena, María José, Beckmann, Richard P., Buchanan, Sean G.

“…Most cancers preserve functional retinoblastoma (Rb) and may, therefore, respond to inhibition of D-cyclin-dependent Rb kinases, CDK4 and CDK6. To date, CDK4/6…”
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Aurora A Kinase Inhibition Is Synthetic Lethal with Loss of the RB1 Tumor Suppressor Gene by Gong, Xueqian, Du, Jian, Parsons, Stephen H, Merzoug, Farhana F, Webster, Yue, Iversen, Philip W, Chio, Li-Chun, Van Horn, Robert D, Lin, Xi, Blosser, Wayne, Han, Bomie, Jin, Shaoling, Yao, Sufang, Bian, Huimin, Ficklin, Chris, Fan, Li, Kapoor, Avnish, Antonysamy, Stephen, Mc Nulty, Ann M, Froning, Karen, Manglicmot, Danalyn, Pustilnik, Anna, Weichert, Kenneth, Wasserman, Stephen R, Dowless, Michele, Marugán, Carlos, Baquero, Carmen, Lallena, María José, Eastman, Scott W, Hui, Yu-Hua, Dieter, Matthew Z, Doman, Thompson, Chu, Shaoyou, Qian, Hui-Rong, Ye, Xiang S, Barda, David A, Plowman, Gregory D, Reinhard, Christoph, Campbell, Robert M, Henry, James R, Buchanan, Sean G

“…Loss-of-function mutations in the retinoblastoma gene are common in several treatment-refractory cancers such as small-cell lung cancer and triple-negative…”
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Genomic landscape and genetic heterogeneity in gastric adenocarcinoma revealed by whole-genome sequencing by Wong, Swee Seong, Kim, Kyoung-Mee, Ting, Jason C., Yu, Kun, Fu, Jake, Liu, Shawn, Cristescu, Razvan, Nebozhyn, Michael, Gong, Lara, Yue, Yong Gang, Wang, Jian, Ronghua, Chen, Loboda, Andrey, Hardwick, James, Liu, Xiaoqiao, Dai, Hongyue, Jin, Jason Gang, Ye, Xiang S., Kang, So Young, Do, In Gu, Park, Joon Oh, Sohn, Tae Sung, Reinhard, Christoph, Lee, Jeeyun, Kim, Sung, Aggarwal, Amit

“…Gastric cancer (GC) is the second most common cause of cancer-related deaths. It is known to be a heterogeneous disease with several molecular and histological…”
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Cdk1 Activity Is Required for Mitotic Activation of Aurora A during G2/M Transition of Human Cells by Van Horn, Robert D., Chu, Shaoyou, Fan, Li, Yin, Tinggui, Du, Jian, Beckmann, Richard, Mader, Mary, Zhu, Guoxin, Toth, John, Blanchard, Kerry, Ye, Xiang S.

“…In mammalian cells entry into and progression through mitosis are regulated by multiple mitotic kinases. How mitotic kinases interact with each other and…”
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Discovery of Cercosporamide, a Known Antifungal Natural Product, as a Selective Pkc1 Kinase Inhibitor through High-Throughput Screening by Sussman, Andrea, Huss, Karen, Chio, Li-Chun, Heidler, Steve, Shaw, Margaret, Ma, Doreen, Zhu, Guoxin, Campbell, Robert M, Park, Tae-Sik, Kulanthaivel, Palaniappan, Scott, John E, Carpenter, John W, Strege, Mark A, Belvo, Matthew D, Swartling, James R, Fischl, Anthony, Yeh, Wu-Kuang, Shih, Chuan, Ye, Xiang S

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Characterization of LY2228820 dimesylate, a potent and selective inhibitor of p38 MAPK with antitumor activity by Campbell, Robert M, Anderson, Bryan D, Brooks, Nathan A, Brooks, Harold B, Chan, Edward M, De Dios, Alfonso, Gilmour, Raymond, Graff, Jeremy R, Jambrina, Enrique, Mader, Mary, McCann, Denis, Na, Songqing, Parsons, Stephen H, Pratt, Susan E, Shih, Chuan, Stancato, Louis F, Starling, James J, Tate, Courtney, Velasco, Juan A, Wang, Yong, Ye, Xiang S

“…p38α mitogen-activated protein kinase (MAPK) is activated in cancer cells in response to environmental factors, oncogenic stress, radiation, and chemotherapy…”
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A Novel Eg5 Inhibitor (LY2523355) Causes Mitotic Arrest and Apoptosis in Cancer Cells and Shows Potent Antitumor Activity in Xenograft Tumor Models by Ye, Xiang S, Fan, Li, Van Horn, Robert D, Nakai, Ryuichiro, Ohta, Yoshihisa, Akinaga, Shiro, Murakata, Chikara, Yamashita, Yoshinori, Yin, Tinggui, Credille, Kelly M, Donoho, Gregory P, Merzoug, Farhana F, Li, Heng, Aggarwal, Amit, Blanchard, Kerry, Westin, Eric H

“…Intervention of cancer cell mitosis by antitubulin drugs is among the most effective cancer chemotherapies. However, antitubulin drugs have dose-limiting side…”
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p38 mitogen-activated protein kinase promotes cell survival in response to DNA damage but is not required for the G(2) DNA damage checkpoint in human cancer cells by Phong, Mark S, Van Horn, Robert D, Li, Shuyu, Tucker-Kellogg, Gregory, Surana, Uttam, Ye, Xiang S

“…p38 mitogen-activated protein kinase (MAPK) is rapidly activated by stresses and is believed to play an important role in the stress response. While Chk1 is…”
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Combined inhibition of PIM and CDK4/6 suppresses both mTOR signaling and Rb phosphorylation and potentiates PI3K inhibition in cancer cells by Litchfield, Lacey M, Boehnke, Karsten, Brahmachary, Manisha, Mur, Cecilia, Bi, Chen, Stephens, Jennifer R, Sauder, J Michael, Gutiérrez, Sonia M, McNulty, Ann M, Ye, Xiang S, Wu, Wenjuan, Lallena, María José, Gong, Xueqian, Merzoug, Farhana F, Jansen, Valerie M, Buchanan, Sean G

“…Aberrant activation of mitogenic signaling pathways in cancer promotes growth and proliferation of cells by activating mTOR and S6 phosphorylation, and…”
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Isolation of functional homolog of the cell cycle-specific NIMA protein kinase of Aspergillus nidulans and functional analysis of conserved residues by Pu, R.T. (Geisinger Clinic, Danville, PA.), Xu, G, Wu, L, Vierula, J, O'Donnell, K, Ye, X.S, Osmani, S.A

“…To investigate the degree of conservation of the cell cycle-specific NIMA protein kinase of Aspergillus nidulans, and to help direct its functional analysis,…”
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Cell Cycle Progression and Cell Polarity Require Sphingolipid Biosynthesis in Aspergillus nidulans by Cheng, Jijun, Park, Tae-Sik, Fischl, Anthony S., Ye, Xiang S.

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Checkpoint defects leading to premature mitosis also cause endoreplication of DNA in Aspergillus nidulans by De Souza, C P, Ye, X S, Osmani, S A

“…The G2 DNA damage and slowing of S-phase checkpoints over mitosis function through tyrosine phosphorylation of NIMX(cdc2) in Aspergillus nidulans. We…”
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Interaction between developmental and cell cycle regulators is required for morphogenesis in Aspergillus nidulans by Ye, X.S, Lee, S.L, Wolkow, T.D, McGuire, S.L, Hamer, J.E, Wood, G.C, Osmani, S.A

“…In Aspergillus nidulans, mutation of the transcriptional regulator brlA arrests formation of asexual spore‐forming structures called conidiophores but does not…”
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Targets of checkpoints controlling mitosis: lessons from lower eukaryotes by Osmani, Stephen A, Ye, Xiang s

“…Prevention of mitosis if DNA is damaged, or not fully replicated, is a widespread mechanism used by eukaryotic cells to maintain their ploidy and prevent…”
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