Search Results - "Ye, Richard D"

Emerging functions of serum amyloid A in inflammation by Ye, Richard D., Sun, Lei

“…Review of potential functions of SAA in inflammation, and open questions requiring further research. SAA is a major acute‐phase protein produced in large…”
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Serum amyloid A1: Structure, function and gene polymorphism by Sun, Lei, Ye, Richard D.

“…Inducible expression of serum amyloid A (SAA) is a hallmark of the acute-phase response, which is a conserved reaction of vertebrates to environmental…”
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The Formyl Peptide Receptors: Diversity of Ligands and Mechanism for Recognition by He, Hui-Qiong, Ye, Richard D

“…The formyl peptide receptors (FPRs) are G protein-coupled receptors that transduce chemotactic signals in phagocytes and mediate host-defense as well as…”
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Role of G protein-coupled receptors in inflammation by Sun, Lei, Ye, Richard D

“…G protein-coupled receptors （GPCRs） play important roles in inflammation. Inflammatory cells such as polymorphonuclear leuko- cytes （PMN）, monocytes and…”
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International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the Formyl Peptide Receptor (FPR) Family by Ye, Richard D, Boulay, François, Wang, Ji Ming, Dahlgren, Claes, Gerard, Craig, Parmentier, Marc, Serhan, Charles N, Murphy, Philip M

“…Formyl peptide receptors (FPRs) are a small group of seven-transmembrane domain, G protein-coupled receptors that are expressed mainly by mammalian phagocytic…”
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Structural basis of ligand binding modes at the human formyl peptide receptor 2 by Chen, Tong, Xiong, Muya, Zong, Xin, Ge, Yunjun, Zhang, Hui, Wang, Mu, Won Han, Gye, Yi, Cuiying, Ma, Limin, Ye, Richard D., Xu, Yechun, Zhao, Qiang, Wu, Beili

“…The human formyl peptide receptor 2 (FPR2) plays a crucial role in host defense and inflammation, and has been considered as a drug target for chronic…”
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In vitro immunomodulatory effects of human milk oligosaccharides on murine macrophage RAW264.7 cells by Zhang, Weiyue, Yan, Jingyu, Wu, Lehao, Yu, Yang, Ye, Richard D., Zhang, Yan, Liang, Xinmiao

“…•Human milk oligosaccharides (HMOs) were separated and characterized.•HMO-7 increased the inflammatory mediators and cytokines production in macrophages.•HMO-7…”
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Structural insights into ligand recognition and activation of the succinate receptor SUCNR1 by Liu, Aijun, Liu, Yezhou, Zhang, Weijia, Ye, Richard D.

“…Succinate, a citric acid cycle intermediate, serves important functions in energy homeostasis and metabolic regulation. Extracellular succinate acts as a…”
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A predicted structure of NADPH Oxidase 1 identifies key components of ROS generation and strategies for inhibition by Liu, Yezhou, Liang, Shiyu, Shi, Danfeng, Zhang, Yue, Bai, Chen, Ye, Richard D

“…NADPH oxidase 1 (NOX1) is primarily expressed in epithelial cells and responsible for local generation of reactive oxygen species (ROS). By specifically…”
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Ex vivo and in vitro effect of serum amyloid a in the induction of macrophage M2 markers and efferocytosis of apoptotic neutrophils by Sun, Lei, Zhou, Huibin, Zhu, Ziyan, Yan, Qian, Wang, Lili, Liang, Qing, Ye, Richard D

“…Macrophages affect the magnitude and duration of inflammatory response in a functionally heterogeneous manner. The phenotype of macrophages is maintained…”
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Bidirectional regulation of neutrophil migration by mitogen-activated protein kinases by Liu, Xiaowen, Ma, Bo, Malik, Asrar B, Tang, Haiyang, Yang, Tao, Sun, Bo, Wang, Gang, Minshall, Richard D, Li, Yan, Zhao, Yong, Ye, Richard D, Xu, Jingsong

“…Neutrophils are early responders and must navigate using spatial cues to arrive at infection sites. Xu and colleagues show that the opposing activities of MAP…”
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The redox-sensitive cation channel TRPM2 modulates phagocyte ROS production and inflammation by Di, Anke, Gao, Xiao-Pei, Qian, Feng, Kawamura, Takeshi, Han, Jin, Hecquet, Claudie, Ye, Richard D, Vogel, Stephen M, Malik, Asrar B

“…The generation of reactive oxygen species needs to be carefully controlled to prevent tissue injury. Malik and colleagues identify a negative feedback…”
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Structure of G protein-coupled receptor GPR1 bound to full-length chemerin adipokine reveals a chemokine-like reverse binding mode by Liu, Aijun, Liu, Yezhou, Chen, Geng, Lyu, Wenping, Ye, Fang, Wang, Junlin, Liao, Qiwen, Zhu, Lizhe, Du, Yang, Ye, Richard D

“…Chemerin is an adipokine with chemotactic activity to a subset of leukocytes. Chemerin binds to 3 G protein-coupled receptors, including chemokine-like…”
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Lipopolysaccharide Stimulates Platelet Secretion and Potentiates Platelet Aggregation via TLR4/MyD88 and the cGMP-Dependent Protein Kinase Pathway by Zhang, Guoying, Han, Jingyan, Welch, Emily J, Ye, Richard D, Voyno-Yasenetskaya, Tatyana A, Malik, Asrar B, Du, Xiaoping, Li, Zhenyu

“…Bacterial LPS induces rapid thrombocytopenia, hypotension, and sepsis. Although growing evidence suggests that platelet activation plays a critical role in…”
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Cryo-EM structure of monomeric CXCL12-bound CXCR4 in the active state by Liu, Yezhou, Liu, Aijun, Li, Xinyu, Liao, Qiwen, Zhang, Weijia, Zhu, Lizhe, Ye, Richard D.

“…CXCR4 binding of its endogenous agonist CXCL12 leads to diverse functions, including bone marrow retention of hematopoietic progenitors and cancer metastasis…”
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Cutting Edge: TLR2 Is a Functional Receptor for Acute-Phase Serum Amyloid A by Cheng, Ni, He, Rong, Tian, Jun, Ye, Patrick P, Ye, Richard D

“…Induced secretion of acute-phase serum amyloid A (SAA) is a host response to danger signals and a clinical indication of inflammation. The biological functions…”
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AKT2 Regulates Pulmonary Inflammation and Fibrosis via Modulating Macrophage Activation by Nie, Yunjuan, Sun, Lei, Wu, Yaxian, Yang, Yaoyao, Wang, Jun, He, Huiqiong, Hu, Yudong, Chang, Yanhua, Liang, Qing, Zhu, Jianwei, Ye, Richard D, Christman, John W, Qian, Feng

“…Idiopathic pulmonary fibrosis (IPF) is a highly lethal pathological process that is characterized by inflammation, fibroblast accumulation, and excessive…”
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Structural basis for recognition of N-formyl peptides as pathogen-associated molecular patterns by Chen, Geng, Wang, Xiankun, Liao, Qiwen, Ge, Yunjun, Jiao, Haizhan, Chen, Qiang, Liu, Yezhou, Lyu, Wenping, Zhu, Lizhe, van Zundert, Gydo C. P., Robertson, Michael J., Skiniotis, Georgios, Du, Yang, Hu, Hongli, Ye, Richard D.

“…The formyl peptide receptor 1 (FPR1) is primarily responsible for detection of short peptides bearing N-formylated methionine (fMet) that are characteristic of…”
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Identification of Alkaloids from Corydalis yanhusuo W. T. Wang as Dopamine D₁ Receptor Antagonists by Using CRE-Luciferase Reporter Gene Assay by Wu, Lehao, Zhang, Weiyue, Qiu, Xin, Wang, Chaoran, Liu, Yanfang, Wang, Zhiwei, Yu, Yang, Ye, Richard D, Zhang, Yan

“…W. T. Wang ( ) has been traditionally used for drug addiction and pain relief in China. In our previous study, we showed that the extract of blocks dopamine…”
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Nedd8 modification of Cullin-5 regulates lipopolysaccharide-induced acute lung injury by Zhu, Ziyan, Sun, Lei, Hao, Rui, Jiang, Hongchao, Qian, Feng, Ye, Richard D

“…Lung infections are major causes of acute lung injury (ALI), with limited effective treatment available. Tumor necrosis factor receptor-associated factor 6…”
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