Search Results - "Ye, Guosen"

TRPV4 inhibition counteracts edema and inflammation and improves pulmonary function and oxygen saturation in chemically induced acute lung injury by Balakrishna, Shrilatha, Song, Weifeng, Achanta, Satyanarayana, Doran, Stephen F, Liu, Boyi, Kaelberer, Melanie M, Yu, Zhihong, Sui, Aiwei, Cheung, Mui, Leishman, Emma, Eidam, Hilary S, Ye, Guosen, Willette, Robert N, Thorneloe, Kevin S, Bradshaw, Heather B, Matalon, Sadis, Jordt, Sven-Eric

“…The treatment of acute lung injury caused by exposure to reactive chemicals remains challenging because of the lack of mechanism-based therapeutic approaches…”
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Discovery of GSK2193874: An Orally Active, Potent, and Selective Blocker of Transient Receptor Potential Vanilloid 4 by Cheung, Mui, Bao, Weike, Behm, David J, Brooks, Carl A, Bury, Michael J, Dowdell, Sarah E, Eidam, Hilary S, Fox, Ryan M, Goodman, Krista B, Holt, Dennis A, Lee, Dennis, Roethke, Theresa J, Willette, Robert N, Xu, Xiaoping, Ye, Guosen, Thorneloe, Kevin S

“…Transient Receptor Potential Vanilloid 4 (TRPV4) is a member of the Transient Receptor Potential (TRP) superfamily of cation channels. TRPV4 is expressed in…”
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Development of Dihydropyridone Indazole Amides as Selective Rho-Kinase Inhibitors by Goodman, Krista B, Cui, Haifeng, Dowdell, Sarah E, Gaitanopoulos, Dimitri E, Ivy, Robert L, Sehon, Clark A, Stavenger, Robert A, Wang, Gren Z, Viet, Andrew Q, Xu, Weiwei, Ye, Guosen, Semus, Simon F, Evans, Christopher, Fries, Harvey E, Jolivette, Larry J, Kirkpatrick, Robert B, Dul, Edward, Khandekar, Sanjay S, Yi, Tracey, Jung, David K, Wright, Lois L, Smith, Gary K, Behm, David J, Bentley, Ross, Doe, Christopher P, Hu, Erding, Lee, Dennis

“…Rho kinase (ROCK1) mediates vascular smooth muscle contraction and is a potential target for the treatment of hypertension and related disorders. Indazole…”
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Observation on the ice crystal formation process of large yellow croaker (Pseudosciaena crocea) and the effect of multiple cryoprotectants pre-soaking treatments on frozen quality by Yang, Zhikang, Ye, Guosen, Yang, Dazhang, Xie, Jing, Huo, Yilin

“…By observing the formation behavior of ice crystals, the quality of food products under different freezing conditions can be intuitively judged. In this paper,…”
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Design of amidobenzimidazole STING receptor agonists with systemic activity by Ramanjulu, Joshi M., Pesiridis, G. Scott, Yang, Jingsong, Concha, Nestor, Singhaus, Robert, Zhang, Shu-Yun, Tran, Jean-Luc, Moore, Patrick, Lehmann, Stephanie, Eberl, H. Christian, Muelbaier, Marcel, Schneck, Jessica L., Clemens, Jim, Adam, Michael, Mehlmann, John, Romano, Joseph, Morales, Angel, Kang, James, Leister, Lara, Graybill, Todd L., Charnley, Adam K., Ye, Guosen, Nevins, Neysa, Behnia, Kamelia, Wolf, Amaya I., Kasparcova, Viera, Nurse, Kelvin, Wang, Liping, Puhl, Ana C., Li, Yue, Klein, Michael, Hopson, Christopher B., Guss, Jeffrey, Bantscheff, Marcus, Bergamini, Giovanna, Reilly, Michael A., Lian, Yiqian, Duffy, Kevin J., Adams, Jerry, Foley, Kevin P., Gough, Peter J., Marquis, Robert W., Smothers, James, Hoos, Axel, Bertin, John

“…Stimulator of interferon genes (STING) is a receptor in the endoplasmic reticulum that propagates innate immune sensing of cytosolic pathogen-derived and self…”
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Discovery of Aminofurazan-azabenzimidazoles as Inhibitors of Rho-Kinase with High Kinase Selectivity and Antihypertensive Activity by Stavenger, Robert A, Cui, Haifeng, Dowdell, Sarah E, Franz, Robert G, Gaitanopoulos, Dimitri E, Goodman, Krista B, Hilfiker, Mark A, Ivy, Robert L, Leber, Jack D, Marino, Joseph P, Oh, Hye-Ja, Viet, Andrew Q, Xu, Weiwei, Ye, Guosen, Zhang, Daohua, Zhao, Yongdong, Jolivette, Larry J, Head, Martha S, Semus, Simon F, Elkins, Patricia A, Kirkpatrick, Robert B, Dul, Edward, Khandekar, Sanjay S, Yi, Tracey, Jung, David K, Wright, Lois L, Smith, Gary K, Behm, David J, Doe, Christopher P, Bentley, Ross, Chen, Zunxuan X, Hu, Erding, Lee, Dennis

“…The discovery, proposed binding mode, and optimization of a novel class of Rho-kinase inhibitors are presented. Appropriate substitution on the 6-position of…”
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Optimization of zero superheat control at the evaporator outlet: Application of EXV and pressure regulation valve by Ma, Xingxing, Wang, Jinfeng, Xie, Jing, Xu, Hao, Ye, Guosen, Jiang, Jilin, Han, Xinrong

“…•Zero-superheat control are explored experimentally.•A method of controlling zero-superheat is proposed.•A stable control with zero superheat is achieved.•The…”
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Evaluation of GSK2789917-induced TRPV4 inhibition in animal models of fluid induced lung injury by Bihari, Shailesh, Costell, Melissa H., Bouchier, Tara, Behm, David J., Burgert, Mark, Ye, Guosen, Bersten, Andrew D., Puukila, Stephanie, Cavallaro, Elena, Sprecher, Dennis L., Dixon, Dani-Louise

“…Administration of bolus intravenous fluids, common in pre-hospital and hospitalised patients, is associated with increased lung vascular permeability and…”
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Design and Optimization of an Acyclic Amine Series of TRPV4 Antagonists by Electronic Modulation of Hydrogen Bond Interactions by Patterson, Jaclyn R, Terrell, Lamont R, Donatelli, Carla A, Holt, Dennis A, Jolivette, Larry J, Rivero, Ralph A, Roethke, Theresa J, Shu, Arthur, Stoy, Patrick, Ye, Guosen, Youngman, Mark, Lawhorn, Brian G

“…Investigation of TRPV4 as a potential target for the treatment of pulmonary edema associated with heart failure generated a novel series of acyclic amine…”
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Discovery of Pyrrolidine Sulfonamides as Selective and Orally Bioavailable Antagonists of Transient Receptor Potential Vanilloid‑4 (TRPV4) by Brnardic, Edward J, Ye, Guosen, Brooks, Carl, Donatelli, Carla, Barton, Linda, McAtee, Jeff, Sanchez, Robert M, Shu, Arthur, Erhard, Karl, Terrell, Lamont, Graczyk-Millbrandt, Grazyna, He, Yanan, Costell, Melissa H, Behm, David J, Roethke, Theresa, Stoy, Patrick, Holt, Dennis A, Lawhorn, Brian G

“…A novel series of pyrrolidine sulfonamide transient receptor potential vanilloid-4 (TRPV4) antagonists was developed by modification of a previously reported…”
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Discovery of GSK2798745: A Clinical Candidate for Inhibition of Transient Receptor Potential Vanilloid 4 (TRPV4) by Brooks, Carl A, Barton, Linda S, Behm, David J, Eidam, Hilary S, Fox, Ryan M, Hammond, Marlys, Hoang, Tram H, Holt, Dennis A, Hilfiker, Mark A, Lawhorn, Brian G, Patterson, Jaclyn R, Stoy, Patrick, Roethke, Theresa J, Ye, Guosen, Zhao, Steve, Thorneloe, Kevin S, Goodman, Krista B, Cheung, Mui

“…GSK2798745, a clinical candidate, was identified as an inhibitor of the transient receptor potential vanilloid 4 (TRPV4) ion channel for the treatment of…”
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Abstract 5574: Degradation of PIP4K2C by novel bivalent functional degrader LRK-A induces tumor regression in CRC by Corse, Emily, Goodman, Krista, O'Shea, Morgan, Ye, Guosen, Chow, Melvyn, Arnold, Julie, Giacalone, Vincent, Hayes, Sebastian, Dube, Erica, Alnemy, Sydney, Adigun, Oluwatimileyin Akinrinmade, Brown, Kristin, d'Hennezel, Eva, Sabatos-Peyton, Catherine

“…Abstract Phosphatidylinositol 5-phosphate 4-kinase, type II, gamma (PIP4K2C) is a lipid kinase with critical roles in vesicular trafficking,…”
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Discovery of 6‑Phenylpyrimido[4,5‑b][1,4]oxazines as Potent and Selective Acyl CoA:Diacylglycerol Acyltransferase 1 (DGAT1) Inhibitors with in Vivo Efficacy in Rodents by Fox, Brian M, Sugimoto, Kazuyuki, Iio, Kiyosei, Yoshida, Atsuhito, Zhang, Jian (Ken), Li, Kexue, Hao, Xiaolin, Labelle, Marc, Smith, Marie-Louise, Rubenstein, Steven M, Ye, Guosen, McMinn, Dustin, Jackson, Simon, Choi, Rebekah, Shan, Bei, Ma, Ji, Miao, Shichang, Matsui, Takuya, Ogawa, Nobuya, Suzuki, Masahiro, Kobayashi, Akio, Ozeki, Hidekazu, Okuma, Chihiro, Ishii, Yukihito, Tomimoto, Daisuke, Furakawa, Noboru, Tanaka, Masahiro, Matsushita, Mutsuyoshi, Takahashi, Mitsuru, Inaba, Takashi, Sagawa, Shoichi, Kayser, Frank

“…The discovery and optimization of a series of acyl CoA:diacylglycerol acyltransferase 1 (DGAT1) inhibitors based on a pyrimido[4,5-b][1,4]oxazine scaffold is…”
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Author Correction: Design of amidobenzimidazole STING receptor agonists with systemic activity by Ramanjulu, Joshi M., Pesiridis, G. Scott, Yang, Jingsong, Concha, Nestor, Singhaus, Robert, Zhang, Shu-Yun, Tran, Jean-Luc, Moore, Patrick, Lehmann, Stephanie, Eberl, H. Christian, Muelbaier, Marcel, Schneck, Jessica L., Clemens, Jim, Adam, Michael, Mehlmann, John, Romano, Joseph, Morales, Angel, Kang, James, Leister, Lara, Graybill, Todd L., Charnley, Adam K., Ye, Guosen, Nevins, Neysa, Behnia, Kamelia, Wolf, Amaya I., Kasparcova, Viera, Nurse, Kelvin, Wang, Liping, Puhl, Ana C., Li, Yue, Klein, Michael, Hopson, Christopher B., Guss, Jeffrey, Bantscheff, Marcus, Bergamini, Giovanna, Reilly, Michael A., Lian, Yiqian, Duffy, Kevin J., Adams, Jerry, Foley, Kevin P., Gough, Peter J., Marquis, Robert W., Smothers, James, Hoos, Axel, Bertin, John

“…Change history: In this Letter, author Ana Puhl was inadvertently omitted; this error has been corrected online. An amendment to this paper has been published…”
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Reverse Hydroxamate Inhibitors of Bone Morphogenetic Protein 1 by Kallander, Lara S., Washburn, David, Hilfiker, Mark A., Eidam, Hilary Schenck, Lawhorn, Brian G., Prendergast, Joanne, Fox, Ryan, Dowdell, Sarah, Manns, Sharada, Hoang, Tram, Zhao, Steve, Ye, Guosen, Hammond, Marlys, Holt, Dennis A., Roethke, Theresa, Hong, Xuan, Reid, Robert A., Gampe, Robert, Zhang, Hong, Diaz, Elsie, Rendina, Alan R., Quinn, Amy M., Willette, Bob

“…Bone Morphogenetic Protein 1 (BMP1) inhibition is a potential method for treating fibrosis because BMP1, a member of the zinc metalloprotease family, is…”
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Discovery of INT131: A selective PPARγ modulator that enhances insulin sensitivity by Taygerly, Joshua P., McGee, Lawrence R., Rubenstein, Steven M., Houze, Jonathan B., Cushing, Timothy D., Li, Yang, Motani, Alykhan, Chen, Jin-Long, Frankmoelle, Walter, Ye, Guosen, Learned, Marc R., Jaen, Juan, Miao, Shichang, Timmermans, Pieter B., Thoolen, Martin, Kearney, Patrick, Flygare, John, Beckmann, Holger, Weiszmann, Jennifer, Lindstrom, Michelle, Walker, Nigel, Liu, Jinsong, Biermann, Donna, Wang, Zhulun, Hagiwara, Atsushi, Iida, Tetsuya, Aramaki, Hisateru, Kitao, Yuki, Shinkai, Hisashi, Furukawa, Noboru, Nishiu, Jun, Nakamura, Motonao

“…PPARγ is a member of the nuclear hormone receptor family and plays a key role in the regulation of glucose homeostasis. This Letter describes the discovery of…”
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Discovery of INT131: A selective PPARI3 modulator that enhances insulin sensitivity by Taygerly, Joshua, McGee, Lawrence, Rubenstein, Steven, Houze, Jonathan, Cushing, Timothy, Li, Yang, Motani, Alykhan, Chen, Jin-Long, Frankmoelle, Walter, Ye, Guosen, Learned, Marc, Jaen, Juan, Miao, Shichang, Timmermans, Pieter, Thoolen, Martin, Kearney, Patrick, Flygare, John, Beckmann, Holger, Weiszmann, Jennifer, Lindstrom, Michelle, Walker, Nigel, Liu, Jinsong, Biermann, Donna, Wang, Zhulun, Hagiwara, Atsushi, Iida, Tetsuya, Aramaki, Hisateru, Kitao, Yuki, Shinkai, Hisashi, Furukawa, Noboru, Nishiu, Jun, Nakamura, Motonao

“…PPARI3 is a member of the nuclear hormone receptor family and plays a key role in the regulation of glucose homeostasis. This Letter describes the discovery of…”
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Discovery of INT131: A selective PPAR[gamma] modulator that enhances insulin sensitivity by Taygerly, Joshua P, McGee, Lawrence R, Rubenstein, Steven M, Houze, Jonathan B, Cushing, Timothy D, Li, Yang, Motani, Alykhan, Chen, Jin-Long, Frankmoelle, Walter, Ye, Guosen, Learned, Marc R, Jaen, Juan, Miao, Shichang, Timmermans, Pieter B, Thoolen, Martin, Kearney, Patrick, Flygare, John, Beckmann, Holger, Weiszmann, Jennifer, Lindstrom, Michelle, Walker, Nigel, Liu, Jinsong, Biermann, Donna, Wang, Zhulun, Hagiwara, Atsushi, Iida, Tetsuya, Aramaki, Hisateru, Kitao, Yuki, Shinkai, Hisashi, Furukawa, Noboru, Nishiu, Jun, Nakamura, Motonao

“…PPAR[gamma] is a member of the nuclear hormone receptor family and plays a key role in the regulation of glucose homeostasis. This Letter describes the…”
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Syntheses and Structure-Activity Relationship Studies of Cryptophycin Unit in D Analogues by Ye, Guosen

“…Cancer is a group of diseases characterized by uncontrolled growth and spread of abnormal cells. If the spread is not controlled, it can result in death,…”
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