Search Results - "Ye, Dien"

(Pro)renin Receptor Inhibition Reprograms Hepatic Lipid Metabolism and Protects Mice From Diet-Induced Obesity and Hepatosteatosis by Ren, Liwei, Sun, Yuan, Lu, Hong, Ye, Dien, Han, Lijuan, Wang, Na, Daugherty, Alan, Li, Furong, Wang, Miaomiao, Su, Fengting, Tao, Wenjun, Sun, Jie, Zelcer, Noam, Mullick, Adam E, Danser, A.H Jan, Jiang, Yizhou, He, Yongcheng, Ruan, Xiongzhong, Lu, Xifeng

“…RATIONALE:An elevated level of plasma LDL (low-density lipoprotein) is an established risk factor for cardiovascular disease. Recently, we reported that the…”
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Angiotensinogen Suppression: A New Tool to Treat Cardiovascular and Renal Disease by Cruz-López, Edwyn O., Ye, Dien, Wu, Congqing, Lu, Hong S., Uijl, Estrellita, Mirabito Colafella, Katrina M., Danser, A.H. Jan

“…Multiple types of renin-angiotensin system (RAS) blockers exist, allowing interference with the system at the level of renin, angiotensin-converting enzyme, or…”
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Conventional Vasopressor and Vasopressor‐Sparing Strategies to Counteract the Blood Pressure–Lowering Effect of Small Interfering RNA Targeting Angiotensinogen by Uijl, Estrellita, Ye, Dien, Ren, Liwei, Mirabito Colafella, Katrina M., van Veghel, Richard, Garrelds, Ingrid M., Lu, Hong S., Daugherty, Alan, Hoorn, Ewout J., Nioi, Paul, Foster, Don, Danser, A. H. Jan

“…Background A single dose of small interfering RNA (siRNA) targeting liver angiotensinogen eliminates hepatic angiotensinogen and lowers blood pressure…”
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Manipulation of components of the renin angiotensin system in renal proximal tubules fails to alter atherosclerosis in hypercholesterolemic mice by Kukida, Masayoshi, Amioka, Naofumi, Ye, Dien, Chen, Hui, Moorleghen, Jessica J., Liang, Ching-Ling, Howatt, Deborah A., Katsumata, Yuriko, Yanagita, Motoko, Sawada, Hisashi, Daugherty, Alan, Lu, Hong S.

“…Background and objective Whole body manipulation of the renin-angiotensin system (RAS) consistently exerts profound effects on experimental atherosclerosis…”
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Fludrocortisone Induces Aortic Pathologies in Mice by Ye, Dien, Wu, Congqing, Chen, Hui, Liang, Ching-Ling, Howatt, Deborah A, Franklin, Michael K, Moorleghen, Jessica J, Tyagi, Samuel C, Uijl, Estrellita, Danser, A H Jan, Sawada, Hisashi, Daugherty, Alan, Lu, Hong S

“…In an experiment designed to explore the mechanisms of fludrocortisone-induced high blood pressure, we serendipitously observed aortic aneurysms in mice…”
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(Pro)renin Receptor Inhibition Reduces Plasma Cholesterol and Triglycerides but Does Not Attenuate Atherosclerosis in Atherosclerotic Mice by Ye, Dien, Yang, Xiaofei, Ren, Liwei, Lu, Hong S, Sun, Yuan, Lin, Hui, Tan, Lunbo, Wang, Na, Nguyen, Genevieve, Bader, Michael, Mullick, Adam E, Danser, A H Jan, Daugherty, Alan, Jiang, Yizhou, Sun, Yidan, Li, Furong, Lu, Xifeng

“…Elevated plasma cholesterol concentrations contributes to ischemic cardiovascular diseases. Recently, we showed that inhibiting hepatic (pro)renin receptor…”
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Acid‐Responsive H2‐Releasing 2D MgB2 Nanosheet for Therapeutic Synergy and Side Effect Attenuation of Gastric Cancer Chemotherapy by Fan, Mingjian, Wen, Yanyuan, Ye, Dien, Jin, Zhaokui, Zhao, Penghe, Chen, Danyang, Lu, Xifeng, He, Qianjun

“…The hydrogen molecule is recognized as a high potential to attenuate toxic side effects of chemotherapy and also enhance chemotherapeutic efficacy, and the…”
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Abstract 446: Complement Component 4 Suppression Accompanies Abatement Of Liver Steatosis In Hepatocyte-specific Angiotensinogen Deficient Mice by Pettey, Alex, Sawada, Hisashi, Ye, Dien, Wu, Congqing, Daugherty, Alan, Lu, Hong S

“…Abstract only Background: Steatosis is a frequently associated with chronic liver disease. Western diet (WD)-induced steatosis has been shown consistently to…”
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COMBINING RENIN-ANGIOTENSIN SYSTEM (RAS) BLOCKADE AND SODIUM-GLUCOSE COTRANSPORTER-2 (SGLT2) INHIBITION IN EXPERIMENTAL DIABETES RESULTS IN SYNERGISTIC BENEFICIAL EFFECTS by Ye, Dien, Cruz-Ló, Edwyn O., Veghel, Richard Van, Garrelds, Ingrid M., Danser, A.H. Jan

“…Objective: To study the combined effect of RAS blockade and SGLT2i in experimental diabetes. Design and method: TGR (mREN2)27 rats (a model of angiotensin…”
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Abstract 560: Fludrocortisone Induces Aortic Pathologies In Mice by Liang, Ching L, Ye, Dien, Wu, Congqing, Howatt, Debroah, Daugherty, Alan, Lu, Hong

“…ObjectiveFludrocortisone, a corticosteroid, is used to treat adrenocortical insufficiency. In a previous study to determine associations between…”
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Abstract P159: Induction Of Human Angiotensinogen In Hepatocytes And Human Renin In Renal Proximal Tubule Cells Does Not Accelerate Atherosclerosis In Mice by Amioka, Naofumi, Kukida, Masayoshi, Ye, Dien, Howatt, Deborah A, Moorleghen, Jessica J, Daugherty, Alan, Lu, Hong

“…Abstract only Objective: Hepatocyte-produced angiotensinogen (AGT) can be filtered by glomeruli and retained in renal proximal tubules. Renin protein has also…”
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Abstract 18: Persistent beneficial effects of angiotensinogen small interfering RNA (siRNA) and valsartan in spontaneously hypertensive rats after drug removal by Cruz-Lopez, Edwyn, Ye, Dien, Van veghel, Richard, Garrelds, Ingrid, Kasper, Anne, Wassarman, Kelly, Tu, Ho-Chou, Zlatev, Ivan, Danser, Jan

“…Abstract only Objective: Dual blockade of the renin-angiotensin system (RAS) with siRNA targeting hepatic angiotensinogen (AGT) plus the angiotensin receptor…”
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Abstract 044: Stimulation Of Intrarenal Angiotensinogen Expression And The Development Of Hypertension And Kidney Injury In Angiotensin II-infused Hepatic Angiotensinogen Knockout Mice by Satou, Ryousuke, Ye, Dien, Lu, Hong S, Katsurada, Akemi, Dugas, Courtney M, Daugherty, Alan, Motazedian, Shahriar, Navar, L G

“…Abstract only Regulation of systemic and local angiotensinogen (AGT) levels is a key determinant of tissue angiotensin II (Ang II) levels and inappropriate AGT…”
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Angiotensinogen Suppression: A New Tool to Treat Cardiovascular and Renal Disease by Cruz-López, Edwyn O., Ye, Dien, Wu, Congqing, Lu, Hong S., Uijl, Estrellita, Mirabito Colafella, Katrina M., Danser, A.H. Jan

“…Multiple types of renin-angiotensin system (RAS) blockers exist, allowing interference with the system at the level of renin, angiotensin-converting enzyme, or…”
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COUNTERACTING ANGIOTENSINOGEN SMALL INTERFERING RNA-MEDIATED ANTIHYPERTENSIVE EFFECTS WITH REVERSIR by López, Edwyn Cruz, Ye, Dien, Van Veghel, Richard, Garrelds, Ingrid M., Kasper, Anne, Wassarman, Kelly, Tu, Ho -Chou, Zlatev, Ivan, Danser, A. H. Jan

“…Objective: Administering small interfering RNA (siRNA) targeting liver angiotensinogen (AGT) effectively depletes circulating AGT, leading to a sustained blood…”
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Abstract 543: Inhibition Of Renin-angiotensin System Failed To Suppress Beta-aminopropionitrile-induced Thoracic Aortopathies In Mice by Sawada, Hisashi, Ohno, Satoko, Ye, Dien, Franklin, Michael, Howatt, Deborah A, Moorleghen, Jessica J, Lu, Hong, Daugherty, Alan

“…ObjectiveCross-linking of elastin and collagen fibers is a vital process in aortic development. Pharmacological inhibition of aortic cross-linking by…”
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Effects of Renin-Angiotensin Inhibition on ACE2 (Angiotensin-Converting Enzyme 2) and TMPRSS2 (Transmembrane Protease Serine 2) Expression: Insights Into COVID-19 by Wu, Congqing, Ye, Dien, Mullick, Adam E., Li, Zhenyu, Danser, A.H. Jan, Daugherty, Alan, Lu, Hong S.

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Abstract P160: Deficiency Of Angiotensin-converting Enzyme In Renal Proximal Convoluted Tubules Does Not Attenuate Atherosclerosis In Mice by Chen, Hui, Masayoshi, Kukida, Ye, Dien, Howatt, Deborah A, Moorleghen, Jessica J, Sawada, Hisashi, Daugherty, Alan, Lu, Hong S

“…Abstract only Objective: Angiotensin-converting enzyme (ACE) is the enzyme to generate Angiotensin II (AngII), an important contributor to atherosclerosis. ACE…”
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Abstract P145: Renal Proximal Tubule-specific Renin Deficiency Has No Effect On Atherosclerosis In Hypercholesterolemic Mice by Ye, Dien, Liang, Chingling, Howatt, Deborah A, Moorleghen, Jessica J, Danser, Jan A, Daugherty, Alan, Lu, Hong

“…Abstract only Objective: Renin cleaving angiotensinogen to release angiotensin I is the rate-limiting step to produce angiotensin II. Although juxtaglomerular…”
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Targeting Angiotensinogen With N -Acetylgalactosamine-Conjugated Small Interfering RNA to Reduce Blood Pressure by Ye, Dien, Cruz-López, Edwyn O, Tu, Ho-Chou, Zlatev, Ivan, Danser, A H Jan

“…Blood pressure management involves antihypertensive therapies blocking the renin-angiotensin system (RAS). Yet, it might be inadequate due to poor patient…”
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