Search Results - "Ye, Caiying"

Carboxyamidotriazole alleviates pannus formation and cartilage erosion in rats with adjuvant arthritis by Zhou, Yongting, Yang, Xiyue, Liu, Jingwen, Yang, Mei, Ye, Caiying, Zhu, Lei

“…Carboxyamidotriazole (CAI) was initially considered a non-cytotoxic anticancer agent. However, recently, pronounced anti-inflammatory properties of CAI have…”
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Carboxyamidotriazole combined with IDO1-Kyn-AhR pathway inhibitors profoundly enhances cancer immunotherapy by Shi, Jing, Chen, Chen, Ju, Rui, Wang, Qingzhu, Li, Juan, Guo, Lei, Ye, Caiying, Zhang, Dechang

“…BackgroundCancer immunotherapy has generated significant excitement, mainly as a result of the development of immune checkpoint inhibitors. The blockade of…”
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MicroRNA-31 inhibits lung adenocarcinoma stem-like cells via down-regulation of MET-PI3K-Akt signaling pathway by Hou, Chunying, Sun, Bo, Jiang, Yao, Zheng, Ji, Yang, Nan, Ji, Chao, Liang, Zhen, Shi, Jiaojiao, Zhang, Rui, Liu, Yanyong, Ye, Caiying, Zuo, Pingping

“…Accumulated evidences suggested that microRNAs (miRs) play an important role in non-small cell lung cancer (NSCLC). However, how miRs perform their functions…”
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Inhibition of pro-inflammatory cytokines in tumour associated macrophages is a potential anti-cancer mechanism of carboxyamidotriazole by Ju, Rui, Wu, Danwei, Guo, Lei, Li, Juan, Ye, Caiying, Zhang, Dechang

“…Abstract Carboxyamidotriazole (CAI) has not only direct anti-cancer activities, but also anti-inflammation effects in a variety of inflammatory animal models…”
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Anti-inflammatory and analgesic potency of carboxyamidotriazole, a tumorostatic agent by Guo, Lei, Ye, Caiying, Chen, Wenying, Ye, Hua, Zheng, Ru, Li, Juan, Yang, Huifen, Yu, Xiaoli, Zhang, Dechang

“…Carboxyamidotriazole (CAI) is a calcium influx inhibitor that is undergoing clinical trials for the treatment of various human cancers following the…”
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Regulator of G protein signaling proteins differentially modulate signaling of μ and δ opioid receptors by Xie, Zhihua, Li, Zhisong, Guo, Lei, Ye, Caiying, Li, Juan, Yu, Xiaoli, Yang, Huifen, Wang, Yulin, Chen, Chongguang, Zhang, Dechang, Liu-Chen, Lee-Yuan

“…Effects of regulator of G protein signaling (RGS) proteins on μ and δ opioid receptors were investigated in HEK293 cells. Co-expression of RGS1, RGS2, RGS4,…”
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AIM2 and NLRC4-driven inflammasome activation in adult-onset Still’s disease and the preliminary therapeutic effect exploration of carboxyamidotriazole by Duan, Mengyuan, Shen, Min, Zhou, Yongting, He, Yi, Guo, Zehao, Ye, Caiying, Li, Juan, Zhu, Lei

“…Objectives This study aimed to explore the changes of four major inflammasomes in adult-onset Still’s disease (AOSD) and preliminarily evaluate the therapeutic…”
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NALP1 inflammasome activation in adjuvant arthritis rats is a novel therapeutic target of carboxyamidotrizole in the treatment of rheumatoid arthritis by Zhu, Lei, Li, Juan, Ye, Caiying

“…Abstract BACKGROUND AND PURPOSE Pro-inflammatory cytokines play an important role in rheumatoid arthritis (RA) and their production is mainly regulated by…”
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Discovery of novel triazole compounds as selective IL-1β releasement inhibitors by Mu, Ruixu, Zhou, Yongting, Chen, Leyuan, Wei, Huiqiang, Yu, Jingcheng, Gou, Wenfeng, Ye, Caiying, Hou, Wenbin, Li, Yiliang, Zhu, Lei

“…[Display omitted] Inflammation and immunity are closely related to the occurrence and development of a variety of immune diseases. Although IL-1β has been…”
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Carboxyamidotriazole inhibits oxidative phosphorylation in cancer cells and exerts synergistic anti-cancer effect with glycolysis inhibition by Ju, Rui, Guo, Lei, Li, Juan, Zhu, Lei, Yu, Xiaoli, Chen, Chen, Chen, Wei, Ye, Caiying, Zhang, Dechang

“…Highlights • CAI is confirmed to inhibit OXPHOS in cancer cells for the first time. • Anti-cancer effect of CAI is greatly improved by being combined with…”
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Therapeutic efficacy of carboxyamidotriazole on 2,4,6-trinitrobenzene sulfonic acid-induced colitis model is associated with the inhibition of NLRP3 inflammasome and NF-κB activation by Du, Xiaowan, Chen, Wei, Wang, Yufeng, Chen, Chen, Guo, Lei, Ju, Rui, Li, Juan, Zhang, Dechang, Zhu, Lei, Ye, Caiying

“…Excess proinflammatory cytokines owing to the activation of NF-κB and NLRP3 inflammasome play the key role in inflammatory bowel disease (IBD). Previously, we…”
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Carboxyamidotriazole Synergizes with Sorafenib to Combat Non-Small Cell Lung Cancer through Inhibition of NANOG and Aggravation of Apoptosis by Chen, Chen, Ju, Rui, Shi, Jing, Chen, Wei, Sun, Fangrui, Zhu, Lei, Li, Juan, Zhang, Dechang, Ye, Caiying, Guo, Lei

“…Lung cancer is currently the leading cause of cancer-related deaths worldwide. In this study, we investigated the combination of carboxyamidotriazole (CAI) and…”
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Improved Free Musculocutaneous Flap Survival with Induction of Heat Shock Protein by Wang, Bernadette H, Ye, Caiying, Stagg, Carole A, Lin, Max, Fawcett, Timothy, VanderKolk, Craig A, Udelsman, Robert

“…The cellular response to a wide variety of stresses results in the synthesis of a family of stress response proteins termed heat shock proteins. Recent studies…”
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Activation of NALP1 inflammasomes in rats with adjuvant arthritis; a novel therapeutic target of carboxyamidotriazole in a model of rheumatoid arthritis by Zhu, Lei, Li, Juan, Guo, Lei, Yu, Xiaoli, Wu, Danwei, Luo, Lifeng, Zhu, Lingzhi, Chen, Wei, Chen, Chen, Ye, Caiying, Zhang, Dechang

“…Background and Purpose Pro‐inflammatory cytokines are important in rheumatoid arthritis (RA) and their production is mainly regulated by NF‐κB and…”
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Carboxyamidotriazole: A novel inhibitor of both cAMP-phosphodiesterases and cGMP-phosphodiesterases by Guo, Lei, Luo, Lifeng, Ju, Rui, Chen, Chen, Zhu, Lei, Li, Juan, Yu, Xiaoli, Ye, Caiying, Zhang, Dechang

“…Carboxyamidotriazole (CAI) is a non-cytotoxic anti-tumor drug, which also shows considerable anti-inflammatory effects in a variety of animal models of…”
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Carboxyamidotriazole exerts anti‑inflammatory activity in lipopolysaccharide‑induced RAW264.7 macrophages by inhibiting NF‑κB and MAPKs pathways by Lu, Shan, Duan, Mengyuan, Guo, Zehao, Zhou, Yongting, Wu, Danwei, Zhang, Xiaojuan, Wang, Yicheng, Ye, Caiying, Ju, Rui, Li, Juan, Zhang, Dechang, Zhu, Lei

“…Carboxyamidotriazole (CAI), originally developed as a non-cytotoxic anti-cancer drug, was shown to have anti-inflammatory activity according to recent studies…”
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Improvement of mitochondrial function mediated the neuroprotective effect of 5-(4-hydroxy-3-dimethoxybenzylidene)-2-thioxo-4-thiazolidinone in rats with cerebral ischemia-reperfusion injuries by Wang, Mingyang, Feng, Lu, Zheng, Ji, Liu, Junya, Fan, Shujie, Zhao, Jun, Yang, Nan, Liu, Yanyong, Yang, Zhanjun, Ye, Caiying, Zuo, Pingping

“…Deficits in mitochondrial function is a critical inducement in the major pathways that drive neuronal cell death in ischemic process particularly. Drugs target…”
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Carboxyamidotriazole exerts anti-inflammatory activity in lipopolysaccharide-induced RAW264.7 macrophages by inhibiting NF-[kappa]B and MAPKs pathways by Lu, Shan, Duan, Mengyuan, Guo, Zehao, Zhou, Yongting, Wu, Danwei, Zhang, Xiaojuan, Wang, Yicheng, Ye, Caiying, Ju, Rui, Li, Juan, Zhang, Dechang, Zhu, Lei

“…Carboxyamidotriazole (CAI), originally developed as a non-cytotoxic anti-cancer drug, was shown to have anti-inflammatory activity according to recent studies…”
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Activation of NALP 1 inflammasomes in rats with adjuvant arthritis; a novel therapeutic target of carboxyamidotriazole in a model of rheumatoid arthritis by Zhu, Lei, Li, Juan, Guo, Lei, Yu, Xiaoli, Wu, Danwei, Luo, Lifeng, Zhu, Lingzhi, Chen, Wei, Chen, Chen, Ye, Caiying, Zhang, Dechang

“…Background and Purpose Pro‐inflammatory cytokines are important in rheumatoid arthritis ( RA ) and their production is mainly regulated by NF ‐ κB and…”
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Carboxyamidotriazole ameliorates experimental colitis by inhibition of cytokine production, nuclear factor-κB activation, and colonic fibrosis by Guo, Lei, Ye, Caiying, Hao, Xiaojian, Zheng, Ru, Ju, Rui, Wu, Danwei, Luo, Lifeng, Wang, Conghui, Li, Juan, Yu, Xiaoli, Zhu, Lei, Zhang, Dechang

“…Carboxyamidotrizole (CAI) has been reported to suppress the production of tumor necrosis factor-α (TNF-α) and interleukin (IL)-1β and be effective in rats with…”
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