Search Results - "Yazlovitskaya, E M"

Cellular oxidative stress response mediates radiosensitivity in Fus1-deficient mice by Yazlovitskaya, E M, Voziyan, P A, Manavalan, T, Yarbrough, W G, Ivanova, A V

“…Mechanism of radiosensitivity of normal tissues, a key factor in determining the toxic side effects of cancer radiotherapy, is not fully understood. We…”
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Effect of Extracellular Signal-regulated Kinase on p53 Accumulation in Response to Cisplatin by Persons, Diane L., Yazlovitskaya, Eugenia M., Pelling, Jill C.

“…The p53 tumor suppressor protein is a transcription factor that plays a major role in the DNA damage response. After DNA damage, p53 levels increase due…”
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Cisplatin-induced Activation of Mitogen-activated Protein Kinases in Ovarian Carcinoma Cells: Inhibition of Extracellular Signal-regulated Kinase Activity Increases Sensitivity to Cisplatin by PERSONS, D. L, YAZLOVITSKAYA, E. M, CUI, W, PELLING, J. C

“…Cisplatin treatment activates multiple signal transduction pathways, which can lead to several cellular responses including cell cycle arrest, DNA repair,…”
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Glycogen synthase kinase 3β inhibitors protect hippocampal neurons from radiation-induced apoptosis by regulating MDM2-p53 pathway by Thotala, D K, Hallahan, D E, Yazlovitskaya, E M

“…Exposure of the brain to ionizing radiation can cause neurocognitive deficiencies. The pathophysiology of these neurological changes is complex and includes…”
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Cytosolic Phospholipase A2 and Lysophospholipids in Tumor Angiogenesis by Linkous, Amanda G., Yazlovitskaya, Eugenia M., Hallahan, Dennis E.

“…Background Lung cancer and glioblastoma multiforme are highly angiogenic and, despite advances in treatment, remain resistant to therapy. Cytosolic…”
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Regulation of p53 target gene expression by cisplatin-induced extracellular signal-regulated kinase by DEHAAN, Ryan D, YAZLOVITSKAYA, Eugenia M, PERSONS, Diane L

“…The extracellular signal-regulated kinase (ERK) pathway is among several signal transduction pathways that are activated in response to exposure to the DNA…”
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A novel radioprotective function for the mitochondrial tumor suppressor protein Fus1 by Yazlovitskaya, E M, Uzhachenko, R, Voziyan, P A, Yarbrough, W G, Ivanova, A V

“…FUS1/TUSC2 is a mitochondrial tumor suppressor with activity to regulate cellular oxidative stress by maintaining balanced ROS production and mitochondrial…”
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Cytosolic phospholipase A2 regulates viability of irradiated vascular endothelium by Yazlovitskaya, E M, Linkous, A G, Thotala, D K, Cuneo, K C, Hallahan, D E

“…Radiosensitivity of various normal tissues is largely dependent on radiation-triggered signal transduction pathways. Radiation simultaneously initiates…”
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Prevention of estrogen carcinogenesis in the hamster kidney by ethinylestradiol : some unique properties of a synthetic estrogen by LI, J. J, XIAOYING HOU, BENTEL, J, YAZLOVITSKAYA, E. M, LI, S. A

“…Ethinylestradiol (EE) has evident paradoxical effects on cancer risk for human breast and hepatic cancer which parallel in some respects its effects on…”
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Induction of cathepsin D protein during estrogen carcinogenesis : possible role in estrogen-mediated kidney tubular cell damage by LI, S. A, LIAO, D.-Z. J, YAZLOVITSKAYA, E. M, PANTAZIS, C. G, LI, J. J

“…We have proposed that an early step in estrogen carcinogenesis in the hamster kidney is tubular damage followed by reparative cell proliferation. This tubular…”
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Cisplatin-induced response of c-jun N-terminal kinase 1 and extracellular signal-regulated protein kinases 1 and 2 in a series of cisplatin-resistant ovarian carcinoma cell lines by Cui, Wei, Yazlovitskaya, Eugenia M., Mayo, Matthew S., Pelling, Jill C., Persons, Diane L.

“…The cellular response to cisplatin involves activation of multiple signal transduction pathways, including the mitogen‐activated protein (MAP) kinase pathways…”
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Prolonged Wild-Type p53 Protein Accumulation and Cisplatin Resistance by Yazlovitskaya, Eugenia M., DeHaan, Ryan D., Persons, Diane L.

“…The major limitation for the chemotherapeutic use of DNA-damaging agent cisplatin is the development of resistance in initially responsive tumors. One of the…”
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Selective farnesol toxicity and translocation of protein kinase C in neoplastic HeLa-S3K and non-neoplastic CF-3 cells by Yazlovitskaya, Eugenia M., Melnykovych, George

“…We have reported earlier that farnesol, a 15 carbon isoprenoid, has inhibitory effects on the growth and viability of a variety of cultured cells of neoplastic…”
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Differences in sensitivity to farnesol toxicity between neoplastically- and non-neoplastically-derived cells in culture by Adany, I, Yazlovitskaya, E M, Haug, J S, Voziyan, P A, Melnykovych, G

“…Six neoplastically-derived cell lines and three cell lines derived from normal tissues were compared for their sensitivity to isoprenoid trans-trans farnesol…”
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Directed cell killing (apoptosis) in human lymphoblastoid cells incubated in the presence of farnesol: effect of phosphatidylcholine by Haug, J S, Goldner, C M, Yazlovitskaya, E M, Voziyan, P A, Melnykovych, G

“…Previously reported observations have shown that trans-trans farnesol inhibits incorporation of choline into phosphatidylcholine and reduces the growth rate of…”
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Novel Radiosensitizing Anticancer Therapeutics by LINKOUS, Amanda G, YAZLOVITSKAYA, Eugenia M

“…In cancer treatment, radiation therapy is second only to surgery in terms of its curative potential. However, radiation-induced tumor cell death is limited by…”
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Glycogen synthase kinase 3[beta] inhibitors protect hippocampal neurons from radiation-induced apoptosis by regulating MDM2-p53 pathway by Thotala, D K, Hallahan, D E, Yazlovitskaya, E M

“…Exposure of the brain to ionizing radiation can cause neurocognitive deficiencies. The pathophysiology of these neurological changes is complex and includes…”
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Association of apoptosis with the inhibition of extracellular signal-regulated protein kinase activity in the tumor necrosis factor α-resistant ovarian carcinoma cell line UCI 101 by Yazlovitskaya, Eugenia M., Pelling, Jill C., Persons, Diane L.

“…Tumor necrosis factor‐α (TNFα) can function as both an autocrine and a paracrine growth factor and may therefore play a role in ovarian tumor progression. TNFα…”
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Cytosolic phospholipase A sub(2) regulates viability of irradiated vascular endothelium by Yazlovitskaya, E M, Linkous, A G, Thotala, D K, Cuneo, K C, Hallahan, D E

“…Radiosensitivity of various normal tissues is largely dependent on radiation-triggered signal transduction pathways. Radiation simultaneously initiates…”
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Protein kinase B/Akt-dependent phosphorylation of glycogen synthase kinase-3β in irradiated vascular endothelium by JIAHUA TAN, LING GENG, YAZLOVITSKAYA, Eugenia M, HALLAHAN, Dennis E

“…Abstract The vascular endothelium plays a critical role in the response of cancer to ionizing radiation. Activation of the phosphoinositide-3-kinase/Akt…”
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