Quantification of Galantamine in Sternbergia Species by High Performance Liquid Chromatography

This study describes the qualitative and quantitative analysis of galantamine in species growing in Turkey. Galantamine was isolated from bulbs and the structure of the compound elucidated by spectroscopic methods. The qualitative and quantitative analysis of galantamine was investigated in subsp. s...

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Bibliographic Details
Published in:	Turkish journal of pharmaceutical sciences Vol. 16; no. 1; pp. 32 - 36
Main Authors:	Acikara, Özlem Bahadır, Yilmaz, Betül Sever, Yazgan, Dilhun, Işcan, Gülçin Saltan
Format:	Journal Article
Language:	English
Published:	Turkey Türk Eczacılar Birliği 01-03-2019 Galenos Publishing House Galenos Publishing
Subjects:	Analgesics Antioxidants Chromatography Eczacılık Original Sağlık Hizmetleri Tıp Ankara Türkiye Ankara Turkey Anatolia Turkey United States > US Galantamine HPLC Sternbergia spp Galantamin
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Summary:	This study describes the qualitative and quantitative analysis of galantamine in species growing in Turkey. Galantamine was isolated from bulbs and the structure of the compound elucidated by spectroscopic methods. The qualitative and quantitative analysis of galantamine was investigated in subsp. subsp. , and using a specially developed and validated high performance liquid chromatography (HPLC) method. subsp. had the highest content of galantamine, i.e., 0.0165±0.0002 g/100 g. The limits of detection and quantification were 7.5 μg and 25 μg, respectively. Isolation of galantamine from growing in Turkey is reported for the first time. An HPLC method was developed for identification and quantification of galantamine in .
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1304-530X 2148-6247
DOI:	10.4274/tjps.95967