TAMEC: a new analogue of cyclomyrsinol diterpenes decreases anxiety- and depression-like behaviors in a mouse model of multiple sclerosis

There is a significant prevalence of affective disorders including depression and anxiety in people with multiple sclerosis (MS), resulting in reduced quality of life. Since the current treatments are not generally effective, further studies are needed to find appropriate drugs to alleviate anxiety...

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Bibliographic Details
Published in:	Neurological research (New York) Vol. 39; no. 12; pp. 1056 - 1065
Main Authors:	Ayatollahi, Abdul Majid, Haji Molla Hoseini, Mostafa, Ghanadian, Syed Mustafa, Kosari-Nasab, Morteza, Mami, Fatemeh, Yazdiniapoure, Zeinab, Zolfaghari, Behzad, Salari, Ali-Akbar
Format:	Journal Article
Language:	English
Published:	England Taylor & Francis 02-12-2017
Subjects:	Animals anxiety Anxiety - drug therapy Anxiety - physiopathology Cyclomyrsinol diterpenes depression Depression - drug therapy Depression - physiopathology Disease Models, Animal Diterpenes - chemistry Diterpenes - isolation & purification Diterpenes - pharmacology EAE Encephalomyelitis, Autoimmune, Experimental - drug therapy Encephalomyelitis, Autoimmune, Experimental - physiopathology Encephalomyelitis, Autoimmune, Experimental - psychology Female Hippocampus - drug effects Hippocampus - metabolism Interleukin-10 - metabolism Interleukin-1beta - metabolism Mice, Inbred C57BL Molecular Structure Psychotropic Drugs - chemistry Psychotropic Drugs - isolation & purification Psychotropic Drugs - pharmacology Tumor Necrosis Factor-alpha - metabolism Cyclomyrsinol diterpenes EAE anxiety depression
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Summary:	There is a significant prevalence of affective disorders including depression and anxiety in people with multiple sclerosis (MS), resulting in reduced quality of life. Since the current treatments are not generally effective, further studies are needed to find appropriate drugs to alleviate anxiety and depression symptoms in these patients. The effects of a new analog of cyclomyrsinol diterpenes (TAMEC) isolated from Euphorbia sogdiana on the anxiety (open field and elevated plus maze test) and depressive-like behaviors (sucrose preference test and forced swim test) in EAE-induced C57BL/6 mice (EAE; a mouse model of MS) were investigated. Hippocampal tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1β and IL-10 levels were also measured by ELISA. The results indicated that TAMEC treatment reduced anxiety and depression-like behavior. This drug also decreased the levels of TNF-α and IL1β and increased IL-10 level in the hippocampus. Taken together, our findings demonstrate that the drug we used here can reduce anxiety and depression-like symptoms in EAE-induced mice. However, more studies are still needed to validate, expand, and generalize these data.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0161-6412 1743-1328
DOI:	10.1080/01616412.2017.1376789