Search Results - "Yazdi, Amir S."

A role for mitochondria in NLRP3 inflammasome activation by Tschopp, Jürg, Zhou, Rongbin, Yazdi, Amir S, Menu, Philippe

“…An inflammatory response initiated by the NLRP3 inflammasome is triggered by a variety of situations of host 'danger', including infection and metabolic…”
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NLRP1 Is the Key Inflammasome in Primary Human Keratinocytes by Burian, Marc, Yazdi, Amir S.

“…The epidermis is the primary area of contact between the body and the environment, and it distinguishes between harmful exposures and those that should be…”
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Molecular Mechanisms of Hair Growth and Regeneration: Current Understanding and Novel Paradigms by Houschyar, Khosrow Siamak, Borrelli, Mimi R, Tapking, Christian, Popp, Daniel, Puladi, Behrus, Ooms, Mark, Chelliah, Malcolm P, Rein, Susanne, Pförringer, Dominik, Thor, Dominik, Reumuth, Georg, Wallner, Christoph, Branski, Ludwik K, Siemers, Frank, Grieb, Gerrit, Lehnhardt, Marcus, Yazdi, Amir S, Maan, Zeshaan N, Duscher, Dominik

“…Hair is a defining feature of mammals and has critical functions, including protection, production of sebum, apocrine sweat and pheromones, social and sexual…”
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Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1α and IL-1β by Yazdi, Amir S, Guarda, Greta, Riteau, Nicolas, Drexler, Stefan K, Tardivel, Aubry, Couillin, Isabelle, Tschopp, Jürg

“…Nanoparticles are increasingly used in various fields, including biomedicine and electronics. One application utilizes the opacifying effect of nano-TiO₂,…”
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Inflammasome Activators Induce Interleukin-1α Secretion via Distinct Pathways with Differential Requirement for the Protease Function of Caspase-1 by Groß, Olaf, Yazdi, Amir S., Thomas, Christina J., Masin, Mark, Heinz, Leonhard X., Guarda, Greta, Quadroni, Manfredo, Drexler, Stefan K., Tschopp, Jurg

“…Through their capacity to sense danger signals and to generate active interleukin-1β (IL-1β), inflammasomes occupy a central role in the inflammatory response…”
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The NLRP1 inflammasome in skin diseases by Burian, Marc, Schmidt, Morna F, Yazdi, Amir S

“…Healthy human skin is constantly exposed to sterile and microbial agents. The skin immune system plays an important role in immune surveillance between…”
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RIPK1 and TRADD Regulate TNF-Induced Signaling and Ripoptosome Formation by Feoktistova, Maria, Makarov, Roman, Yazdi, Amir S, Panayotova-Dimitrova, Diana

“…TNF is a proinflammatory cytokine that is critical for the coordination of tissue homeostasis. RIPK1 and TRADD are the main participants in the transduction of…”
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Differential expression of NLRP3 among hematopoietic cells by Guarda, Greta, Zenger, Manuel, Yazdi, Amir S, Schroder, Kate, Ferrero, Isabel, Menu, Philippe, Tardivel, Aubry, Mattmann, Chantal, Tschopp, Jürg

“…Although the importance of the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome in health and disease is well appreciated, a precise…”
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Transcriptional Profiling of Staphylococcus aureus during the Transition from Asymptomatic Nasal Colonization to Skin Colonization/Infection in Patients with Atopic Dermatitis by Li, Peijuan, Schulte, Julia, Wurpts, Gerda, Hornef, Mathias W, Wolz, Christiane, Yazdi, Amir S, Burian, Marc

“…acts both as a colonizing commensal bacterium and invasive pathogen. Nasal colonization is associated with an increased risk of infection caused by the…”
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Transcriptional adaptation of staphylococci during colonization of the authentic human environment: An overview of transcriptomic changes and their relationship to physiological conditions by Burian, Marc, Wolz, Christiane, Yazdi, Amir S.

“…Staphylococci are commensals of human skin and mucous membranes, but some species can also cause serious infections. Host niches during both colonization and…”
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Tissue-specific opposing functions of the inflammasome adaptor ASC in the regulation of epithelial skin carcinogenesis by Drexler, Stefan K, Bonsignore, Luca, Masin, Mark, Tardivel, Aubry, Jackstadt, Rene, Hermeking, Heiko, Schneider, Pascal, Gross, Olaf, Tschopp, Jurg, Yazdi, Amir S

“…A chronic inflammatory microenvironment favors tumor progression through molecular mechanisms that are still incompletely defined. In inflammation-induced skin…”
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Apremilast prevents blistering in human epidermis and stabilizes keratinocyte adhesion in pemphigus by Sigmund, Anna M., Winkler, Markus, Engelmayer, Sophia, Kugelmann, Daniela, Egu, Desalegn T., Steinert, Letyfee S., Fuchs, Michael, Hiermaier, Matthias, Radeva, Mariya Y., Bayerbach, Franziska C., Butz, Elisabeth, Kotschi, Stefan, Hudemann, Christoph, Hertl, Michael, Yeruva, Sunil, Schmidt, Enno, Yazdi, Amir S., Ghoreschi, Kamran, Vielmuth, Franziska, Waschke, Jens

“…Pemphigus vulgaris is a life-threatening blistering skin disease caused by autoantibodies destabilizing desmosomal adhesion. Current therapies focus on…”
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Macrophage migration inhibitory factor (MIF) and its homolog D-dopachrome tautomerase (D-DT) are significant promotors of UVB- but not chemically induced non-melanoma skin cancer by Huth, Sebastian, Huth, Laura, Heise, Ruth, Marquardt, Yvonne, Lopopolo, Linda, Piecychna, Marta, Boor, Peter, Fingerle-Rowson, Günter, Kapurniotu, Aphrodite, Yazdi, Amir S., Bucala, Richard, Bernhagen, Jürgen, Baron, Jens Malte

“…Non-melanoma skin cancer (NMSC) is the most common cancer in Caucasians worldwide. We investigated the pathophysiological role of MIF and its homolog D-DT in…”
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The Staphylococcus epidermidis Transcriptional Profile During Carriage by Teichmann, Pascâl, Both, Anna, Wolz, Christiane, Hornef, Mathias W, Rohde, Holger, Yazdi, Amir S, Burian, Marc

“…The virulence factors of the opportunistic human pathogen have been a main subject of research. In contrast, limited information is available on the mechanisms…”
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Innate immune activation as cofactor in pemphigus disease manifestation by Eichkorn, Ramona A., Schmidt, Morna F., Walter, Elias, Hertl, Michael, Baron, Jens Malte, Waschke, Jens, Yazdi, Amir S.

“…Molecular mechanisms underlying auto-antibody-induced acantholysis in pemphigus vulgaris are subject of current research to date. To decipher the discrepancy…”
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Adaptation of Staphylococcus aureus to the Human Skin Environment Identified Using an ex vivo Tissue Model by Burian, Marc, Plange, Johanna, Schmitt, Laurenz, Kaschke, Anke, Marquardt, Yvonne, Huth, Laura, Baron, Jens M., Hornef, Mathias W., Wolz, Christiane, Yazdi, Amir S.

“…The healthy human epidermis provides physical protection and is impenetrable for pathogenic microbes. Nevertheless, commensal and pathogen bacteria such as…”
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Silencing of ASC in Cutaneous Squamous Cell Carcinoma by Meier, Katharina, Drexler, Stefan K, Eberle, Franziska C, Lefort, Karine, Yazdi, Amir S

“…Apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) is an important adaptor protein for inflammasome activation, mediating…”
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TNF Is Partially Required for Cell-Death-Triggered Skin Inflammation upon Acute Loss of cFLIP by Feoktistova, Maria, Makarov, Roman, Leverkus, Martin, Yazdi, Amir S, Panayotova-Dimitrova, Diana

“…cFLIP is required for epidermal integrity and skin inflammation silencing via protection from TNF-induced keratinocyte apoptosis. Here, we generated and…”
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Activation of hypoxia inducible factor 1 is a general phenomenon in infections with human pathogens by Werth, Nadine, Beerlage, Christiane, Rosenberger, Christian, Yazdi, Amir S, Edelmann, Markus, Amr, Amro, Bernhardt, Wanja, von Eiff, Christof, Becker, Karsten, Schäfer, Andrea, Peschel, Andreas, Kempf, Volkhard A J

“…Hypoxia inducible factor (HIF)-1 is the key transcriptional factor involved in the adaptation process of cells and organisms to hypoxia. Recent findings…”
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Author Correction: Apremilast prevents blistering in human epidermis and stabilizes keratinocyte adhesion in pemphigus by Sigmund, Anna M., Winkler, Markus, Engelmayer, Sophia, Kugelmann, Daniela, Egu, Desalegn T., Steinert, Letyfee S., Fuchs, Michael, Hiermaier, Matthias, Radeva, Mariya Y., Bayerbach, Franziska C., Butz, Elisabeth, Kotschi, Stefan, Hudemann, Christoph, Hertl, Michael, Yeruva, Sunil, Schmidt, Enno, Yazdi, Amir S., Ghoreschi, Kamran, Vielmuth, Franziska, Waschke, Jens

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