Search Results - "Yawe, Joseph C."

Local Proliferation of Macrophages Contributes to Obesity-Associated Adipose Tissue Inflammation by Amano, Shinya U., Cohen, Jessica L., Vangala, Pranitha, Tencerova, Michaela, Nicoloro, Sarah M., Yawe, Joseph C., Shen, Yuefei, Czech, Michael P., Aouadi, Myriam

“…Adipose tissue (AT) of obese mice and humans accumulates immune cells, which secrete cytokines that can promote insulin resistance. AT macrophages (ATMs) are…”
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Gene silencing in adipose tissue macrophages regulates whole-body metabolism in obese mice by Aouadi, Myriam, Tencerova, Michaela, Vangala, Pranitha, Yawe, Joseph C., Nicoloro, Sarah M., Amano, Shinya U., Cohen, Jessica L., Czech, Michael P.

“…Adipose tissue (AT) inflammation and infiltration by macrophages is associated with insulin resistance and type 2 diabetes in obese humans, offering a…”
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Endothelial protein kinase MAP4K4 promotes vascular inflammation and atherosclerosis by Roth Flach, Rachel J., Skoura, Athanasia, Matevossian, Anouch, Danai, Laura V., Zheng, Wei, Cortes, Christian, Bhattacharya, Samit K., Aouadi, Myriam, Hagan, Nana, Yawe, Joseph C., Vangala, Pranitha, Menendez, Lorena Garcia, Cooper, Marcus P., Fitzgibbons, Timothy P., Buckbinder, Leonard, Czech, Michael P.

“…Signalling pathways that control endothelial cell (EC) permeability, leukocyte adhesion and inflammation are pivotal for atherosclerosis initiation and…”
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Activated Kupffer cells inhibit insulin sensitivity in obese mice by Tencerova, Michaela, Aouadi, Myriam, Vangala, Pranitha, Nicoloro, Sarah M., Yawe, Joseph C., Cohen, Jessica L., Shen, Yuefei, Garcia‐Menendez, Lorena, Pedersen, David J., Gallagher‐Dorval, Karen, Perugini, Richard A., Gupta, Olga T., Czech, Michael P.

“…ABSTRACT Obesity promotes insulin resistance associated with liver inflammation, elevated glucose production, and type 2 diabetes. Although insulin resistance…”
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Lipid storage by adipose tissue macrophages regulates systemic glucose tolerance by Aouadi, Myriam, Vangala, Pranitha, Yawe, Joseph C, Tencerova, Michaela, Nicoloro, Sarah M, Cohen, Jessica L, Shen, Yuefei, Czech, Michael P

“…Proinflammatory pathways in adipose tissue macrophages (ATMs) can impair glucose tolerance in obesity, but ATMs may also be beneficial as repositories for…”
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Endothelial Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 Is Critical for Lymphatic Vascular Development and Function by Roth Flach, Rachel J., Guo, Chang-An, Danai, Laura V., Yawe, Joseph C., Gujja, Sharvari, Edwards, Yvonne J. K., Czech, Michael P.

“…The molecular mechanisms underlying lymphatic vascular development and function are not well understood. Recent studies have suggested a role for endothelial…”
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Map4k4 impairs energy metabolism in endothelial cells and promotes insulin resistance in obesity by Roth Flach, Rachel J, DiStefano, Marina T, Danai, Laura V, Senol-Cosar, Ozlem, Yawe, Joseph C, Kelly, Mark, Garcia Menendez, Lorena, Czech, Michael P

“…The blood vasculature responds to insulin, influencing hemodynamic changes in the periphery, which promotes tissue nutrient and oxygen delivery and thus…”
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Peptide- and Amine-Modified Glucan Particles for the Delivery of Therapeutic siRNA by Cohen, Jessica L, Shen, Yuefei, Aouadi, Myriam, Vangala, Pranitha, Tencerova, Michaela, Amano, Shinya U, Nicoloro, Sarah M, Yawe, Joseph C, Czech, Michael P

“…Translation of siRNA technology into the clinic is limited by the need for improved delivery systems that target specific cell types. Macrophages are…”
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