Tear Osmolarity Measurements in Dry Eye Related to Primary Sjögren's Syndrome

Tear Osmolarity Measurements in Dry Eye Related to Primary Sjögren's Syndrome

Background: To evaluate the tear osmolarity in patients with dry eye syndrome related to primary Sjögren's Syndrome (SS). Materials and Methods: Twenty eyes of 10 patients with dry eye and primary SS (Group 1) and 20 eyes of 20 subjects who do not have dry eye syndrome (Group 2) were included i...

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Published in:Current eye research Vol. 36; no. 8; pp. 683 - 690
Main Authors: Utine, Canan Asli, B çakç gil, Müge, Yavuz, ule, Çiftçi, Ferda
Format: Journal Article
Language:English
Published: England Informa Healthcare 01-08-2011
Taylor & Francis
Subjects:
Adult
Cross-Sectional Studies
Dry eye
Dry Eye Syndromes - classification
Dry Eye Syndromes - diagnosis
Female
Fluorescein - metabolism
Humans
Male
Ocular surface
Osmolar Concentration
Sjogren's Syndrome - classification
Sjogren's Syndrome - diagnosis
Sjögren's syndrome
Staining and Labeling - methods
Tear osmolarity
TearLab
Tears - chemistry
Young Adult
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Summary:Background: To evaluate the tear osmolarity in patients with dry eye syndrome related to primary Sjögren's Syndrome (SS). Materials and Methods: Twenty eyes of 10 patients with dry eye and primary SS (Group 1) and 20 eyes of 20 subjects who do not have dry eye syndrome (Group 2) were included in this cross-sectional study. In all eyes, ophthalmic examination was performed in the same order: International Ocular Surface Disease Index survey, visual acuity assessment, conjunctival hyperemia scoring, tear osmolarity measurement with TearLab™ Osmolarity System, tear film break-up time assessment, corneal fluorescein staining scoring, ocular surface Lissamine Green staining scoring, anesthetized Schirmer test. Dry eye severity was graded according to Dry Eye Workshop (DEWS) classification system. Results: Four eyes with grade 1, four eyes with grade 2, seven eyes with grade 3, and five eyes with grade 4 dryness, according to DEWS system, were included. The mean tear osmolarity value was 301.9 ± 11.40 mOsm/L (range: 290-328) in Group 1, and 294.85 ± 8.33 mOsm/L (range: 283-311) in Group 2 (p = 0.03). In Group 1, tear osmolarity values were positively correlated with OSDI scores (r(18) = 0.55, r2 = 0.31, p = 0.01), DEWS classification grades (r(18) = 0.73, r2 = 0.54, p < 0.01), temporal and total corneal staining scores (r(18) = 0.67, r2 = 0.44, p < 0.01, and r(18) = 0.51, r2 = 0.26, p = 0.02, respectively), temporal conjunctival staining scores (r(18) = 58, r2 = 0.34, p < 0.01); and negatively correlated with anesthetized Schirmer test results (r(18) = -0.62, r2 = 0.38, p < 0.01) and TFBUT (r(18) = -0.50, r2 = 0.25, p = 0.02). Conclusions: Tear osmolarity values were found to be greater in patients with dry eye syndrome related to primary SS compared to control subjects, and positively correlated with the severity of dry eye.
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ISSN:0271-3683
1460-2202
DOI:10.3109/02713683.2011.571357