Search Results - "Yavuz, Akif S"

Clinical features and survival of patients with indolent systemic mastocytosis defined by the updated WHO classification by Trizuljak, Jakub, Sperr, Wolfgang R., Nekvindová, Lucie, Elberink, Hanneke O., Gleixner, Karoline V., Gorska, Aleksandra, Lange, Magdalena, Hartmann, Karin, Illerhaus, Anja, Bonifacio, Massimiliano, Perkins, Cecelia, Elena, Chiara, Malcovati, Luca, Fortina, Anna B., Shoumariyeh, Khalid, Jawhar, Mohamad, Zanotti, Roberta, Bonadonna, Patrizia, Caroppo, Francesca, Zink, Alexander, Triggiani, Massimo, Parente, Roberta, Bubnoff, Nikolas, Yavuz, Akif S., Hägglund, Hans, Mattsson, Mattias, Panse, Jens, Jäkel, Nadja, Kilbertus, Alex, Hermine, Olivier, Arock, Michel, Fuchs, David, Sabato, Vito, Brockow, Knut, Bretterklieber, Agnes, Niedoszytko, Marek, Anrooij, Björn, Reiter, Andreas, Gotlib, Jason, Kluin‐Nelemans, Hanneke C., Mayer, Jiri, Doubek, Michael, Valent, Peter

“…Background In indolent systemic mastocytosis (ISM), several risk factors of disease progression have been identified. Previous studies, performed with limited…”
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Analysis of the lineage relationship between mast cells and basophils using the c- kit D816V mutation as a biologic signature by Kocabas, Can N., Yavuz, Akif S., Lipsky, Peter E., Metcalfe, Dean D., Akin, Cem

“…Mast cells and basophils share similar morphologic and functional properties; however, it is not known whether they are derived from a bilineage (basophil/mast…”
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A novel form of mastocytosis associated with a transmembrane c-kit mutation and response to imatinib by Akin, Cem, Fumo, Gerard, Yavuz, Akif S., Lipsky, Peter E., Neckers, Len, Metcalfe, Dean D.

“…Mutational analysis of the c-kit gene in a patient with a previously undescribed variant of mast cell disease revealed a germline mutation, Phe522Cys, within…”
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Frontline nilotinib treatment in Turkish patients with Philadelphia chromosome-positive chronic Myeloid Leukemia in chronic phase: updated results with 2 years of follow-up by Saydam, Guray, Haznedaroglu, Ibrahim Celalettin, Kaynar, Leylagul, Yavuz, Akif S, Ali, Ridvan, Guvenc, Birol, Akay, Olga M, Baslar, Zafer, Ozbek, Ugur, Sonmez, Mehmet, Aydin, Demet, Pehlivan, Mustafa, Undar, Bulent, Dagdas, Simten, Ayyildiz, Orhan, Akin, Gülnur, Dag, Ilkiz M, Ilhan, Osman

“…This report presents final results (24 months of follow-up) from the first prospective, national study of frontline nilotinib in chronic myeloid leukemia (CML)…”
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Outcomes with frontline nilotinib treatment in Turkish patients with newly diagnosed Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase by Saydam, Guray, Haznedaroglu, Ibrahim Celalettin, Kaynar, Leylagul, Yavuz, Akif S, Ali, Ridvan, Guvenc, Birol, Akay, Olga M, Baslar, Zafer, Ozbek, Ugur, Sonmez, Mehmet, Aydin, Demet, Pehlivan, Mustafa, Undar, Bulent, Dagdas, Simten, Ayyildiz, Orhan, Akkaynak, Diyar Z, Dag, Ilkiz M, Ilhan, Osman

“…Nilotinib is a BCR-ABL1 tyrosine kinase inhibitor approved for the treatment of patients with chronic myeloid leukemia in chronic phase (CML-CP). This study…”
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Analysis of activation-induced cytidine deaminase mRNA levels in patients with chronic lymphocytic leukemia with different cytogenetic status by Gelmez, Metin Y., Teker, Aysegul B. A., Aday, Aynur D., Yavuz, Akif S., Soysal, Teoman, Deniz, Gunnur, Aktan, Melih

“…Abstract Activation induced cytidine deaminase (AID) enzyme, which converts cytosine into uracil and is expressed only by activated B lymphocytes, plays a role…”
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The role of polymerase eta in somatic hypermutation determined by analysis of mutations in a patient with xeroderma pigmentosum variant by Yavuz, Sule, Yavuz, Akif S, Kraemer, Kenneth H, Lipsky, Peter E

“…To determine the possible role of polymerase eta (pol eta) in somatic hypermutation of B cells, a mutational analysis of 24 nonproductive rearrangements from a…”
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Short-course use of recombinant factor VIIa in a haemophilia patient with inhibitor undergoing cataract surgeries by Pekçelen, Yüksel, Yavuz, Akif S, Namli, Sule, Gücükoglu, Ahmet

“…A 36 year-old patient with severe haemophilia A and high-titre inhibitor underwent cataract surgery under topical anaesthesia. Recombinant factor VIIa was used…”
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Different patterns of bcl-6 and p53 gene mutations in tonsillar B cells indicate separate mutational mechanisms by Yavuz, Akif S, Monson, Nancy L, Yavuz, Sule, Grammer, Amrie C, Longo, Nancy, Girschick, Hermann J, Lipsky, Peter E

“…Mutations within the 5′-non-coding region of the bcl-6 gene can occur in lymphomas that originate from germinal centers (GCs), as well as in normal memory and…”
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Can Activation Induced Cytidine Deaminase Lead to Genetic Instability in Bcr-Abl Negative Myeloproliferative Neoplasms? by Dermenci, Hasan, Daglar, Aynur, Akadam, Basak Peker, Hancer, Veysel Sabri, Gelmez, Yusuf, Aktan, Melih, Nalcaci, Meliha, Yavuz, Akif S.

“…Abstract 5056 Most patients with myeloproliferative neoplasms (MPN) have mutations that lead to constitutive activation of the tyrosine kinase signal…”
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Nilotinib Results in Improved Rates of Molecular Response in Turkish Newly Diagnosed CML-CP Patients: A 24-Month Update by Saydam, Guray, Haznedaroglu, Ibrahim Celalettin, Kaynar, Leylagul, Yavuz, Akif S., Ali, Ridvan, Guvenc, Birol, Akay, Olga M., Baslar, Zafer, Ozbek, Ugur, Sonmez, Mehmet, Aydin, Demet, Pehlivan, Mustafa, Undar, Bulent, Dagdas, Simten, Ayyildiz, Orhan M., Akkaynak, Diyar Z., Dag, Ilkiz M., Ilhan, Osman

“…Introduction Nilotinib, a more potent and selective BCR-ABL-1 inhibitor than imatinib, is approved by the FDA and EMA 1) for the treatment of chronic and…”
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Use Of Nilotinib As a First Line Treatment In Adult Patients With Philadelphia Chromosome-Positive and Chronic Phase Myeloid Leukemia by Saydam, Guray, Haznedaroglu, Ibrahim C., Kaynar, Leylagul, Yavuz, Akif S., Ali, Ridvan, Guvenc, Birol, Akay, Olga M., Baslar, Zafer, Ozbek, Ugur, Sonmez, Mehmet, Aydin, Demet, Pehlivan, Mustafa, Undar, Bulent, Dagdas, Simten, Ayyildiz, Orhan M., Akkaynak, Diyar Z., Dag, Ilkiz M., Ilhan, Osman

“…Nilotinib, a more potent and selective drug than imatinib, was approved by the FDA and EMA initially for the treatment of chronic and accelerated phase…”
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Analysis of Bone Mineral Density, Biochemical Bone Turnover Markers and Serum Tryptase Levels in Patients with Systemic Mastocytosis (SM) by Yavuz, Akif S., Alpay, Nilüfer, Dogan, Öner, Büyükbabani, Nesimi, Baykal, Can, Sindel, Dilsad, Pekçelen, Yüksel, Tanakol, Refik

“…Osteoporosis, osteosclerosis and lytic lesions, have been observed in patients with SM possibly reflecting different amounts of infiltrating mast cells and…”
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Analysis of the lineage relationship between mast cells and basophils using the c-kitD816V mutation as a biologic signature by Kocabas, Can N, Yavuz, Akif S, Lipsky, Peter E, Metcalfe, Dean D, Akin, Cem

“…Background Mast cells and basophils share similar morphologic and functional properties; however, it is not known whether they are derived from a bilineage…”
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The Role of Polymerase {eta} in Somatic Hypermutation Determined by Analysis of Mutations in a Patient with Xeroderma Pigmentosum Variant by Yavuz, Sule, Yavuz, Akif S, Kraemer, Kenneth H, Lipsky, Peter E

“…To determine the possible role of polymerase [eta] (pol [eta]) in somatic hypermutation of B cells, a mutational analysis of 24 nonproductive rearrangements…”
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