Search Results - "Yau, J L W"

Forebrain‐Specific Transgene Rescue of 11β‐HSD1 Associates with Impaired Spatial Memory and Reduced Hippocampal Brain‐Derived Neurotrophic Factor mRNA Levels in Aged 11β‐HSD1 Deficient Mice by Caughey, S., Harris, A. P., Seckl, J. R., Holmes, M. C., Yau, J. L. W.

“…Mice lacking the intracellular glucocorticoid‐regenerating enzyme 11β‐hydroxysteroid dehydrogenase type 1 (11β‐HSD1) are protected from age‐related spatial…”
Get full text

Decreased Npas4 and Arc mRNA Levels in the Hippocampus of Aged Memory-Impaired Wild-Type But Not Memory Preserved 11β-HSD1 Deficient Mice by Qiu, J., Dunbar, D. R., Noble, J., Cairns, C., Carter, R., Kelly, V., Chapman, K. E., Seckl, J. R., Yau, J. L. W.

“…Mice deficient in the glucocorticoid‐regenerating enzyme 11β‐HSD1 resist age‐related spatial memory impairment. To investigate the mechanisms and pathways…”
Get full text

Tonic activity and GABA responsiveness of medial vestibular nucleus neurons in aged rats by Him, A, Johnston, A R, Yau, J L. W, Seckl, J, Dutia, M B

“…The tonic discharge of rat medial vestibular nucleus (MVN) neurons, and their responsiveness to GABA receptor agonists were investigated in slices prepared…”
Get full text

Dehydroepiandrosterone 7-hydroxylase cyp7b: predominant expression in primate hippocampus and reduced expression in alzheimer's disease by Yau, J.L.W, Rasmuson, S, Andrew, R, Graham, M, Noble, J, Olsson, T, Fuchs, E, Lathe, R, Seckl, J.R

“…Neurosteroids such as dehydroepiandrosterone (DHEA), pregnenolone and 17β-estradiol are synthesized by cytochrome P450s from endogenous cholesterol. We…”
Get full text

Differential regulation of corticosteroid receptors by monoamine neurotransmitters and antidepressant drugs in primary hippocampal culture by LAI, M, MCCORMICK, J. A, CHAPMAN, K. E, KELLY, P. A. T, SECKL, J. R, YAU, J. L. W

“…Hyperactivity of the hypothalamic-pituitary-adrenal axis is a characteristic feature of depressive illness. The centrally located corticosteroid receptors, the…”
Get full text

5′-Heterogeneity of Glucocorticoid Receptor Messenger RNA Is Tissue Specific: Differential Regulation of Variant Transcripts by Early-Life Events by McCormick, J. A, Lyons, V, Jacobson, M. D, Noble, J, Diorio, J, Nyirenda, M, Weaver, S, Ester, W, Yau, J. L. W, Meaney, M. J, Seckl, J. R, Chapman, K. E

“…Glucocorticoid receptor (GR) gene expression is regulated in a complex tissue-specific manner, notably by early-life environmental events that program tissue…”
Get full text

11β-hydroxysteroid dehydrogenase type I in the brain; thickening the glucocorticoid soup by Yau, J L W, Seckl, J R

Get full text

Forebrain-Specific Transgene Rescue of 11[beta]-HSD1 Associates with Impaired Spatial Memory and Reduced Hippocampal Brain-Derived Neurotrophic Factor mRNA Levels in Aged 11[beta]-HSD1 Deficient Mice by Caughey, S, Harris, A P, Seckl, J R, Holmes, M C, Yau, J L W

“…Mice lacking the intracellular glucocorticoid-regenerating enzyme 11[beta]-hydroxysteroid dehydrogenase type 1 (11[beta]-HSD1) are protected from age-related…”
Get full text

Decreased Npas4 and ArcmRNA Levels in the Hippocampus of Aged Memory-Impaired Wild-Type But Not Memory Preserved 11[beta]-HSD1 Deficient Mice by Qiu, J, Dunbar, D R, Noble, J, Cairns, C, Carter, R, Kelly, V, Chapman, K E, Seckl, J R, Yau, J L W

“…Mice deficient in the glucocorticoid-regenerating enzyme 11[beta]-HSD1 resist age-related spatial memory impairment. To investigate the mechanisms and pathways…”
Get full text

Decreased Npas4 and Arc mRNA Levels in the Hippocampus of Aged Memory‐Impaired Wild‐Type But Not Memory Preserved 11β‐ HSD 1 Deficient Mice by Qiu, J., Dunbar, D. R., Noble, J., Cairns, C., Carter, R., Kelly, V., Chapman, K. E., Seckl, J. R., Yau, J. L. W.

“…Mice deficient in the glucocorticoid‐regenerating enzyme 11β‐ HSD 1 resist age‐related spatial memory impairment. To investigate the mechanisms and pathways…”
Get full text

Modulation of the GABAA receptor by barbiturates and pregnane steroids: differential effects of the influence of assay temperature by Yau, J L, Balfour, D J, Stevenson, I H

“…The effect of temperature on the modulation of the GABAA receptor by barbiturates and steroids has been investigated in-vitro using a radioreceptor binding…”
Get more information

11[beta]-hydroxysteroid dehydrogenase type I in the brain; thickening the glucocorticoid soup by Yau, J L W, Seckl, J R

Get full text

11b-hydroxysteroid dehydrogenase type I in the brain; thickening the glucocorticoid soup by Yau, J L W, Seckl, J R

Get full text

Continuous blockade of brain mineralocorticoid receptors impairs spatial learning in rats by Yau, Joyce L.W, Noble, June, Seckl, Jonathan R

“…Hippocampal mineralocorticoid receptors (MR) are proposed to mediate facilitation of cognition in the short-term. The acute central blockade of MR increases…”
Get full text

Glucocorticoids, hippocampal corticosteroid receptor gene expression and antidepressant treatment: relationship with spatial learning in young and aged rats by Yau, J.L.W., Olsson, T., Morris, R.G.M., Meaney, M.J., Seckl, J.R.

“…The emergence of cognitive deficits in a subgroup of aged rats is associated with increased hypothalamic-pituitary-adrenal axis activity, decreased hippocampal…”
Get full text

Site-specific regulation of corticosteroid and serotonin receptor subtype gene expression in the rat hippocampus following 3,4-methylenedioxymethamphetamine: role of corticosterone and serotonin by Yau, J.L.W, Noble, J, Seckl, J.R

“…Abnormal interactions between serotonin (5-hydroxytryptamine) and glucocorticoids, notably in the hippocampus, may underpin neuroendocrine, affective and…”
Get full text

The effect of adrenalectomy on 5-hydroxytryptamine and corticosteroid receptor subtype messenger RNA expression in rat hippocampus by Holmes, M.C., Yau, J.L.W., French, K.L., Seckl, J.R.

“…Both central serotonergic dysfunction and glucocorticoid hypersecretion have been separately implicated in the aetiology of affective disorders. The…”
Get full text

Impact of adrenalectomy on 5-HT6 and 5-HT7 receptor gene expression in the rat hippocampus by YAU, J. L. W, NOBLE, J, WIDDOWSON, J, SECKL, J. R

“…Both glucocorticoid excess and decreased serotonergic (5-HT) transmission may cause depression. The recently cloned 5-HT6 and 5-HT7 receptors have high…”
Get full text

Chronic amitriptyline administration increases serotonin transporter binding sites in the hippocampus of aged rats by Yau, Joyce L.W, Kelly, Paul A.T, Olsson, Tommy, Noble, June, Seckl, Jonathan R

“…The effects of ageing and of chronic antidepressant treatment upon 5-HT transporter sites ([ 3H]paroxetine binding) in the rat hippocampus was examined. […”
Get full text

Chronic 3,4-methylenedioxymethamphetamine administration decreases glucocorticoid and mineralocorticoid receptor, but increases 5-hydroxytryptamine1C receptor gene expression in the rat hippocampus by Yau, J L, Kelly, P A, Sharkey, J, Seckl, J R

“…Both glucocorticoids and serotonin have been implicated in the regulation of mood and neuroendocrine control. In this study we have examined the effects of the…”
Get more information