Search Results - "Yates, Susan"
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Structural and mechanistic insights into the bifunctional enzyme isocitrate dehydrogenase kinase/phosphatase AceK
Published in Philosophical transactions of the Royal Society of London. Series B. Biological sciences (19-09-2012)“…The switch between the Krebs cycle and the glyoxylate bypass is controlled by isocitrate dehydrogenase kinase/phosphatase (AceK). AceK, a bifunctional enzyme,…”
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High prevalence of latent tuberculosis and bloodborne virus infection in a homeless population
Published in Thorax (01-06-2018)“…Urban homeless populations in the UK have been shown to have high rates of active tuberculosis, but less is known about the prevalence of latent tuberculosis…”
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Long-Term Data Reveal Complex Dynamics in Grassland in Relation to Climate and Disturbance
Published in Ecological monographs (01-11-2007)“…We conducted a long-term experiment in grassland with the aim of elucidating grassland dynamics in relation to variations in rainfall amount and spatial and…”
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Living with Dementia in Aotearoa (LiDiA): a cross-sectional feasibility study protocol for a multiethnic dementia prevalence study in Aotearoa/New Zealand
Published in BMJ open (03-05-2021)“…IntroductionAotearoa/New Zealand (NZ) is officially recognised as a bicultural country composed of Māori and non-Māori. Recent estimations have projected a…”
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Do Māori and Pacific Peoples Living with Dementia in New Zealand Receive Equitable Long-Term Care Compared with New Zealand Europeans?
Published in Journal of long-term care (14-09-2022)“…Context: Compared to Europeans, Māori and Pacific peoples living with dementia in the Counties Manukau District Health Board region are three times less likely…”
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Exotoxin A-eEF2 complex structure indicates ADP ribosylation by ribosome mimicry
Published in Nature (18-08-2005)“…The bacteria causing diphtheria, whooping cough, cholera and other diseases secrete mono-ADP-ribosylating toxins that modify intracellular proteins. Here, we…”
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Stealth and mimicry by deadly bacterial toxins
Published in Trends in biochemical sciences (Amsterdam. Regular ed.) (01-02-2006)“…Diphtheria toxin and exotoxin A are well-characterized members of the ADP-ribosyltransferase toxin family that function as virulence factors in the pathogenic…”
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Predictors of Aged Residential Care Placement in Patients Newly Diagnosed with Dementia at a New Zealand Memory Service
Published in Journal of long-term care (2021)“…Background: Aged residential care (ARC) is a significant cost of dementia care. However, little is known about the predictors of ARC placement in New Zealand…”
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Structural Basis of the Substrate Specificity of Bifunctional Isocitrate Dehydrogenase Kinase/Phosphatase
Published in Biochemistry (Easton) (27-09-2011)“…Isocitrate dehydrogenase kinase/phosphatase (AceK) regulates entry into the glyoxylate bypass by reversibly phosphorylating isocitrate dehydrogenase (ICDH). On…”
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Structure-function analysis of water-soluble inhibitors of the catalytic domain of exotoxin A from Pseudomonas aeruginosa
Published in Biochemical journal (01-02-2005)“…The mono-ADPRT (mono-ADP-ribosyltransferase), Pseudomonas aeruginosa ETA (exotoxin A), catalyses the transfer of ADP-ribose from NAD+ to its protein substrate…”
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Overexpression of cardiac actin with baculovirus is promoter dependent
Published in Archives of biochemistry and biophysics (01-10-2007)“…The influence of the promoter and an N-terminal hexahistidine tag on human cardiac actin (ACTC) expression and function was investigated using four baculovirus…”
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Actin polymerization is controlled by residue size at position 204
Published in Biochemistry and cell biology (01-12-2009)“…Previous work has shown that purified double mutant A204C/C374A yeast actin is polymerization-deficient in vitro under physiological concentrations. To…”
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Crystal Structure of ADP-ribosylated Ribosomal Translocase from Saccharomyces cerevisiae
Published in The Journal of biological chemistry (29-10-2004)“…The crystal structure of ADP-ribosylated yeast elongation factor 2 in the presence of sordarin and GDP has been determined at 2.6 Ã resolution. The…”
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Characterization of oxidized nicotinamide adenine dinucleotide (NAD +) analogues using a high-pressure-liquid-chromatography-based NAD +-glycohydrolase assay and comparison with fluorescence-based measurements
Published in Analytical biochemistry (01-05-2005)“…A high-pressure-liquid-chromatography (HPLC)-based technique was developed to assess the oxidized nicotinamide adenine dinucleotide (NAD +)-glycohydrolase…”
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Linkage Disequilibrium at the Angelman Syndrome Gene UBE3A in Autism Families
Published in Genomics (San Diego, Calif.) (01-09-2001)“…Autistic disorder is a neurodevelopmental disorder with a complex genetic etiology. Observations of maternal duplications affecting chromosome 15q11–q13 in…”
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Elucidation of eukaryotic elongation factor-2 contact sites within the catalytic domain of Pseudomonas aeruginosa exotoxin A
Published in Biochemical journal (01-05-2004)“…Pseudomonas aeruginosa produces the virulence factor, ETA (exotoxin A), which catalyses an ADP-ribosyltransferase reaction of its target protein, eEF2…”
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Absence of MeCP2 mutations in patients from the South Carolina autism project
Published in American journal of medical genetics. Part B, Neuropsychiatric genetics (15-02-2003)“…The methyl‐CpG binding protein 2 (MeCP2) gene has recently been identified as the gene responsible for Rett syndrome (RS), a pervasive developmental disorder…”
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Insight into the catalytic mechanism of Pseudomonas aeruginosa exotoxin A. Studies of toxin interaction with eukaryotic elongation factor-2
Published in The Journal of biological chemistry (29-11-2002)“…The molecular nature of the protein-protein interactions between the catalytic domain from Pseudomonas aeruginosa exotoxin A (PE24H) and its protein substrate,…”
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Exploring older people’s attitudes and preferences around the use of their routinely collected healthcare data in brain health research
Published in Alzheimer's & dementia (01-12-2023)“…Background Over 50% of dementia in NZ may be due to high prevalence of risk factors such as hypertension, diabetes and cardiovascular disease. If so, a better…”
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Carers' perspective on adapting the iSupport in New Zealand
Published in Alzheimer's & dementia (01-12-2023)“…Background The World Health Organisation (WHO) has developed ‘iSupport for Dementia’, a self‐paced training for family carers of people with dementia…”
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