Search Results - "Yates, Luke A"

The Long and Short of MicroRNA by Yates, Luke A., Norbury, Chris J., Gilbert, Robert J.C.

“…MicroRNAs (miRNAs) are versatile regulators of gene expression in higher eukaryotes. In order to silence many different mRNAs in a precise manner, miRNA…”
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Structural basis of homologous recombination by Sun, Yueru, McCorvie, Thomas J., Yates, Luke A., Zhang, Xiaodong

“…Homologous recombination (HR) is a pathway to faithfully repair DNA double-strand breaks (DSBs). At the core of this pathway is a DNA recombinase, which, as a…”
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Structures and regulations of ATM and ATR, master kinases in genome integrity by Williams, Rhys M, Yates, Luke A, Zhang, Xiaodong

“…•cryo-EM structures of ATMTel1 and ATRMec1 reveal the molecular basis for their intrinsically low kinase activities.•PRD-Insert plays key roles in maintaining…”
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A structural and dynamic model for the assembly of Replication Protein A on single-stranded DNA by Yates, Luke A., Aramayo, Ricardo J., Pokhrel, Nilisha, Caldwell, Colleen C., Kaplan, Joshua A., Perera, Rajika L., Spies, Maria, Antony, Edwin, Zhang, Xiaodong

“…Replication Protein A (RPA), the major eukaryotic single stranded DNA-binding protein, binds to exposed ssDNA to protect it from nucleases, participates in a…”
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A DNA damage–induced phosphorylation circuit enhances Mec1ATR Ddc2ATRIP recruitment to Replication Protein A by Yates, Luke A, Tannous, Elias A, Morgan, R Marc, Burgers, Peter M, Zhang, Xiaodong

“…The cell cycle checkpoint kinase Mec1ATR and its integral partner Ddc2ATRIP are vital for the DNA damage and replication stress response. Mec1–Ddc2 "senses"…”
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Dominant carnivore loss benefits native avian and invasive mammalian scavengers by Fielding, Matthew W, Cunningham, Calum X, Buettel, Jessie C, Stojanovic, Dejan, Yates, Luke A, Jones, Menna E, Brook, Barry W

“…Scavenging by large carnivores is integral for ecosystem functioning by limiting the build-up of carrion and facilitating widespread energy flows. However, top…”
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Optimal Translational Termination Requires C4 Lysyl Hydroxylation of eRF1 by Feng, Tianshu, Yamamoto, Atsushi, Wilkins, Sarah E., Sokolova, Elizaveta, Yates, Luke A., Münzel, Martin, Singh, Pooja, Hopkinson, Richard J., Fischer, Roman, Cockman, Matthew E., Shelley, Jake, Trudgian, David C., Schödel, Johannes, McCullagh, James S.O., Ge, Wei, Kessler, Benedikt M., Gilbert, Robert J., Frolova, Ludmila Y., Alkalaeva, Elena, Ratcliffe, Peter J., Schofield, Christopher J., Coleman, Mathew L.

“…Efficient stop codon recognition and peptidyl-tRNA hydrolysis are essential in order to terminate translational elongation and maintain protein sequence…”
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Structure and lipid-binding properties of the kindlin-3 pleckstrin homology domain by Ni, Tao, Kalli, Antreas C, Naughton, Fiona B, Yates, Luke A, Naneh, Omar, Kozorog, Mirijam, Anderluh, Gregor, Sansom, Mark S P, Gilbert, Robert J C

“…Kindlins co-activate integrins alongside talin. They possess, like talin, a FERM domain (4.1-erythrin-radixin-moiesin domain) comprising F0-F3 subdomains, but…”
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Cryo-EM Structure of Nucleotide-Bound Tel1ATM Unravels the Molecular Basis of Inhibition and Structural Rationale for Disease-Associated Mutations by Yates, Luke A., Williams, Rhys M., Hailemariam, Sarem, Ayala, Rafael, Burgers, Peter, Zhang, Xiaodong

“…Yeast Tel1 and its highly conserved human ortholog ataxia-telangiectasia mutated (ATM) are large protein kinases central to the maintenance of genome…”
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Structural plasticity of Cid1 provides a basis for its distributive RNA terminal uridylyl transferase activity by Yates, Luke A, Durrant, Benjamin P, Fleurdépine, Sophie, Harlos, Karl, Norbury, Chris J, Gilbert, Robert J C

“…Terminal uridylyl transferases (TUTs) are responsible for the post-transcriptional addition of uridyl residues to RNA 3' ends, leading in some cases to altered…”
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Structural basis for the activity of a cytoplasmic RNA terminal uridylyl transferase by Yates, Luke A, Fleurdépine, Sophie, Rissland, Olivia S, De Colibus, Luigi, Harlos, Karl, Norbury, Chris J, Gilbert, Robert J C

“…The post-transcriptional addition of uridyl ribonucleotides by terminal uridyltransferases (TUTases) to the ′A ends of various cytoplasmic RNAs, including…”
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Cross validation for model selection: A review with examples from ecology by Yates, Luke A., Aandahl, Zach, Richards, Shane A., Brook, Barry W.

“…Specifying, assessing, and selecting among candidate statistical models is fundamental to ecological research. Commonly used approaches to model selection are…”
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Regulation of DNA break repair by RNA by Yates, Luke A.

“…Genomic stability is critical for cell survival and its effective repair when damaged is a vital process for preserving genetic information. Failure to…”
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Phosphoregulation of the checkpoint kinase Mec1ATR by Yates, Luke A., Zhang, Xiaodong

“…Yeast Mec1, and its mammalian ortholog, Ataxia-Telangiectasia and Rad3-related, are giant protein kinases central to replication stress and double strand DNA…”
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Parsimonious model selection using information theory: a modified selection rule by Yates, Luke A., Richards, Shane A., Brook, Barry W.

“…Information-theoretic approaches to model selection, such as Akaike’s information criterion (AIC) and cross validation, provide a rigorous framework to select…”
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Spatial pattern analysis of line‐segment data in ecology by Yates, Luke A., Brook, Barry W., Buettel, Jessie C.

“…The spatial analysis of linear features (lines and curves) is a challenging and rarely attempted problem in ecology. Existing methods are typically expressed…”
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Why some countries but not others? Urbanisation, GDP and endemic disease predict global SARS-CoV-2 excess mortality patterns by Fountain-Jones, Nicholas M., Charleston, Michael, Flies, Emily J., Carver, Scott, Yates, Luke A.

“…Context The global impact of the SARS-CoV-2 pandemic has been uneven, with some regions experiencing significant excess mortality while others have been…”
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A DNA damage-induced phosphorylation circuit enhances Mec1 ATR Ddc2 ATRIP recruitment to Replication Protein A by Yates, Luke A, Tannous, Elias A, Morgan, R Marc, Burgers, Peter M, Zhang, Xiaodong

“…The cell cycle checkpoint kinase Mec1 and its integral partner Ddc2 are vital for the DNA damage and replication stress response. Mec1-Ddc2…”
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Southeast Asian biodiversity is a fifth lower in deforested versus intact forests by Botterill-James, Thomas, Yates, Luke A, Buettel, Jessie C, Aandahl, Zach, Brook, Barry W

“…Abstract Southeast Asia is highly biodiverse and currently experiences among the highest rates of tropical deforestation globally, but impacts on biodiversity…”
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Roadkill islands: Carnivore extinction shifts seasonal use of roadside carrion by generalist avian scavenger by Fielding, Matthew W., Buettel, Jessie C., Brook, Barry W., Stojanovic, Dejan, Yates, Luke A.

“…Global road networks facilitate habitat modification and are integral to human expansion. Many animals, particularly scavengers, use roads as they provide a…”
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