Search Results - "Yates, Edwin A"

Metabolism of multiple glycosaminoglycans by Bacteroides thetaiotaomicron is orchestrated by a versatile core genetic locus by Ndeh, Didier, Baslé, Arnaud, Strahl, Henrik, Yates, Edwin A., McClurgg, Urszula L., Henrissat, Bernard, Terrapon, Nicolas, Cartmell, Alan

“…The human gut microbiota (HGM), which is critical to human health, utilises complex glycans as its major carbon source. Glycosaminoglycans represent an…”
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SimpleDSFviewer: A tool to analyze and view differential scanning fluorimetry data for characterizing protein thermal stability and interactions by Sun, Changye, Li, Yong, Yates, Edwin A., Fernig, David G.

“…Differential scanning fluorimetry (DSF) is a widely used thermal shift assay for measuring protein stability and protein–ligand interactions that are simple,…”
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Functions and specificity of bacterial carbohydrate sulfatases targeting host glycans by Luis, Ana S, Yates, Edwin A, Cartmell, Alan

“…Sulfated host glycans (mucin O-glycans and glycosaminoglycans [GAGs]) are critical nutrient sources and colonisation factors for Bacteroidetes of the human gut…”
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A single sulfatase is required to access colonic mucin by a gut bacterium by Luis, Ana S., Jin, Chunsheng, Pereira, Gabriel Vasconcelos, Glowacki, Robert W. P., Gugel, Sadie R., Singh, Shaleni, Byrne, Dominic P., Pudlo, Nicholas A., London, James A., Baslé, Arnaud, Reihill, Mark, Oscarson, Stefan, Eyers, Patrick A., Czjzek, Mirjam, Michel, Gurvan, Barbeyron, Tristan, Yates, Edwin A., Hansson, Gunnar C., Karlsson, Niclas G., Cartmell, Alan, Martens, Eric C.

“…Humans have co-evolved with a dense community of microbial symbionts that inhabit the lower intestine. In the colon, secreted mucus creates a barrier that…”
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Unfractionated heparin inhibits live wild type SARS‐CoV‐2 cell infectivity at therapeutically relevant concentrations by Tree, Julia A., Turnbull, Jeremy E., Buttigieg, Karen R., Elmore, Michael J., Coombes, Naomi, Hogwood, John, Mycroft‐West, Courtney J., Lima, Marcelo A., Skidmore, Mark A., Karlsson, Richard, Chen, Yen‐Hsi, Yang, Zhang, Spalluto, Cosma Mirella, Staples, Karl J., Yates, Edwin A., Gray, Elaine, Singh, Dave, Wilkinson, Tom, Page, Clive P., Carroll, Miles W.

“…Background and Purpose Currently, there are no licensed vaccines and limited antivirals for the treatment of COVID‐19. Heparin (delivered systemically) is…”
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Intrinsic tryptophan fluorescence spectroscopy reliably determines galectin-ligand interactions by Sindrewicz, Paulina, Li, Xiaoxin, Yates, Edwin A., Turnbull, Jeremy E., Lian, Lu-Yun, Yu, Lu-Gang

“…Galectins are involved in the regulation of divergent physiological and pathological processes and are increasingly recognized to play important roles in a…”
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Should We Be Worried About Clostridioides difficile During the SARS-CoV2 Pandemic? by Ferreira, Eliane de Oliveira, Penna, Bruno, Yates, Edwin A.

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Sulfated glycan recognition by carbohydrate sulfatases of the human gut microbiota by Luis, Ana S, Baslé, Arnaud, Byrne, Dominic P., Wright, Gareth S. A., London, James A., Jin, Chunsheng, Karlsson, Niclas G., Hansson, Gunnar C., Eyers, Patrick A., Czjzek, Mirjam, Barbeyron, Tristan, Yates, Edwin A., Martens, Eric C., Cartmell, Alan

“…Sulfated glycans are ubiquitous nutrient sources for microbial communities that have coevolved with eukaryotic hosts. Bacteria metabolize sulfated glycans by…”
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Differential Solvent DEEP-STD NMR and MD Simulations Enable the Determinants of the Molecular Recognition of Heparin Oligosaccharides by Antithrombin to Be Disentangled by Parafioriti, Michela, Elli, Stefano, Muñoz-García, Juan C, Ramírez-Cárdenas, Jonathan, Yates, Edwin A, Angulo, Jesús, Guerrini, Marco

“…The interaction of heparin with antithrombin (AT) involves a specific sequence corresponding to the pentasaccharide GlcNAc/NS6S-GlcA-GlcNS3S6S-IdoA2S-GlcNS6S…”
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Introduction to the Molecules Special Edition Entitled ' Heparan Sulfate and Heparin: Challenges and Controversies ': Some Outstanding Questions in Heparan Sulfate and Heparin Research by Yates, Edwin A, Gallagher, John T, Guerrini, Marco

“…The scope of this article is to provide a brief general introduction to heparan sulfate (HS) and heparin, and attempt to identify some of the central…”
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Chemical Modification of Glycosaminoglycan Polysaccharides by Palhares, Lais C. G. F., London, James A., Kozlowski, Aleksandra M., Esposito, Emiliano, Chavante, Suely F., Ni, Minghong, Yates, Edwin A.

“…The linear anionic class of polysaccharides, glycosaminoglycans (GAGs), are critical throughout the animal kingdom for developmental processes and the…”
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Glycation of Host Proteins Increases Pathogenic Potential of Porphyromonas gingivalis by Śmiga, Michał, Smalley, John W, Ślęzak, Paulina, Brown, Jason L, Siemińska, Klaudia, Jenkins, Rosalind E, Yates, Edwin A, Olczak, Teresa

“…The non-enzymatic addition of glucose (glycation) to circulatory and tissue proteins is a ubiquitous pathophysiological consequence of hyperglycemia in…”
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Chemokine CXCL4 interactions with extracellular matrix proteoglycans mediate widespread immune cell recruitment independent of chemokine receptors by Gray, Anna L., Karlsson, Richard, Roberts, Abigail R.E., Ridley, Amanda J.L., Pun, Nabina, Khan, Bakhtbilland, Lawless, Craig, Luís, Rafael, Szpakowska, Martyna, Chevigné, Andy, Hughes, Catherine E., Medina-Ruiz, Laura, Birchenough, Holly L., Mulholland, Iashia Z., Salanga, Catherina L., Yates, Edwin A., Turnbull, Jeremy E., Handel, Tracy M., Graham, Gerard J., Jowitt, Thomas A., Schiessl, Ingo, Richter, Ralf P., Miller, Rebecca L., Dyer, Douglas P.

“…Leukocyte recruitment from the vasculature into tissues is a crucial component of the immune system but is also key to inflammatory disease. Chemokines are…”
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Differentiation of Generic Enoxaparins Marketed in the United States by Employing NMR and Multivariate Analysis by Guerrini, Marco, Rudd, Timothy R, Mauri, Lucio, Macchi, Eleonora, Fareed, Jawed, Yates, Edwin A, Naggi, Annamaria, Torri, Giangiacomo

“…The U.S. Food and Drug Administration defines criteria for the equivalence of Enoxaparin with Lovenox, comprising the equivalence of physiochemical properties,…”
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Subverting the mechanisms of cell death: flavivirus manipulation of host cell responses to infection by Vicenzi, Elisa, Pagani, Isabel, Ghezzi, Silvia, Taylor, Sarah L, Rudd, Timothy R, Lima, Marcelo A, Skidmore, Mark A, Yates, Edwin A

“…Viruses exploit host metabolic and defence machinery for their own replication. The flaviviruses, which include Dengue (DENV), Yellow Fever (YFV), Japanese…”
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Sulfated polysaccharides interact with fibroblast growth factors and protect from denaturation by Sun, Changye, Liu, Mengxin, Sun, Panwen, Yang, Mingming, Yates, Edwin A., Guo, Zhikun, Fernig, David G.

“…Fibroblast growth factors (FGFs) regulate embryonic development and homeostasis, including tissue and organ repair and specific aspects of metabolism. The…”
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Author Correction: Metabolism of multiple glycosaminoglycans by Bacteroides thetaiotaomicron is orchestrated by a versatile core genetic locus by Ndeh, Didier, Baslé, Arnaud, Strahl, Henrik, Yates, Edwin A., McClurgg, Urszula L., Henrissat, Bernard, Terrapon, Nicolas, Cartmell, Alan

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Human (α2→6) and Avian (α2→3) Sialylated Receptors of Influenza A Virus Show Distinct Conformations and Dynamics in Solution by Sassaki, Guilherme L, Elli, Stefano, Rudd, Timothy R, Macchi, Eleonora, Yates, Edwin A, Naggi, Annamaria, Shriver, Zachary, Raman, Rahul, Sasisekharan, R, Torri, Giangiacomo, Guerrini, Marco

“…Differential interactions between influenza A virus protein hemagglutinin (HA) and α2→3 (avian) or α2→6 (human) sialylated glycan receptors play an important…”
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A semi-synthetic glycosaminoglycan analogue inhibits and reverses Plasmodium falciparum cytoadherence by Skidmore, Mark A, Mustaffa, Khairul Mohd Fadzli, Cooper, Lynsay C, Guimond, Scott E, Yates, Edwin A, Craig, Alister G

“…A feature of mature Plasmodium falciparum parasitized red blood cells is their ability to bind surface molecules of the microvascular endothelium via the…”
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Heparin binding preference and structures in the fibroblast growth factor family parallel their evolutionary diversification by Li, Yong, Sun, Changye, Yates, Edwin A., Jiang, Chao, Wilkinson, Mark C., Fernig, David G.

“…The interaction of a large number of extracellular proteins with heparan sulfate (HS) regulates their transport and effector functions, but the degree of…”
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