Search Results - "Yates, Christopher"

The Phyre2 web portal for protein modeling, prediction and analysis by Kelley, Lawrence A, Mezulis, Stefans, Yates, Christopher M, Wass, Mark N, Sternberg, Michael J E

“…Phyre2 is a web-based tool for predicting and analyzing protein structure and function. Phyre2 uses advanced remote homology detection methods to build 3D…”
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The Effects of Non-Synonymous Single Nucleotide Polymorphisms (nsSNPs) on Protein–Protein Interactions by Yates, Christopher M., Sternberg, Michael J.E.

“…Non-synonymous single nucleotide polymorphisms (nsSNPs) are single base changes leading to a change to the amino acid sequence of the encoded protein. Many of…”
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SuSPect: Enhanced Prediction of Single Amino Acid Variant (SAV) Phenotype Using Network Features by Yates, Christopher M., Filippis, Ioannis, Kelley, Lawrence A., Sternberg, Michael J.E.

“…Whole-genome and exome sequencing studies reveal many genetic variants between individuals, some of which are linked to disease. Many of these variants lead to…”
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The interaction of PRC2 with RNA or chromatin is mutually antagonistic by Beltran, Manuel, Yates, Christopher M, Skalska, Lenka, Dawson, Marcus, Reis, Filipa P, Viiri, Keijo, Fisher, Cynthia L, Sibley, Christopher R, Foster, Benjamin M, Bartke, Till, Ule, Jernej, Jenner, Richard G

“…Polycomb repressive complex 2 (PRC2) modifies chromatin to maintain genes in a repressed state during development. PRC2 is primarily associated with CpG…”
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Design and optimization of highly-selective fungal CYP51 inhibitors by Hoekstra, William J, Garvey, Edward P, Moore, William R, Rafferty, Stephen W, Yates, Christopher M, Schotzinger, Robert J

“…While the orally-active azoles such as voriconazole and itraconazole are effective antifungal agents, they potently inhibit a broad range of off-target human…”
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Challenges and controversies in management of pancreatic neuroendocrine tumours in patients with MEN1 by Yates, Christopher J, PhD, Newey, Paul J, DPhil, Thakker, Rajesh V, Prof

“…Summary Multiple endocrine neoplasia type 1 (MEN1), an autosomal dominant disorder, is characterised by the occurrence of pancreatic neuroendocrine tumours…”
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Design and optimization of highly-selective, broad spectrum fungal CYP51 inhibitors by Yates, Christopher M., Garvey, Edward P., Shaver, Sammy R., Schotzinger, Robert J., Hoekstra, William J.

“…[Display omitted] While the orally-active azoles such as fluconazole and posaconazole are effective antifungal agents, they potently inhibit a broad range of…”
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Acute intoxication caused by synthetic cannabinoids 5F-ADB and MMB-2201: a case series by Barceló Martín, Bernardino, Pichini, Simona, López-Corominas, Victoria, Gomila Muñiz, Isabel, Yates Bailo, Christopher, Busardò, Francesco Paolo, Pellegrini, Manuela

“…Highlights • Synthetic cannabinoids have recently been present in the Spanish drug market. • Five young patients with intoxication by synthetic cannabinoids…”
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Ambiguous medical abbreviation study: challenges and opportunities by Holper, Sarah, Barmanray, Rahul, Colman, Blake, Yates, Christopher J., Liew, Danny, Smallwood, David

“…Background Healthcare workers often abbreviate for convenience, but ambiguous abbreviations may cause miscommunication, which jeopardises patient care. Robust…”
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Fungal-specific Cyp51 inhibitor VT-1598 demonstrates in vitro activity against Candida and Cryptococcus species, endemic fungi, including Coccidioides species, Aspergillus species and Rhizopus arrhizus by Wiederhold, Nathan P, Patterson, Hoja P, Tran, Bich Hue, Yates, Christopher M, Schotzinger, Robert J, Garvey, Edward P

“…Invasive fungal infections, including those caused by yeasts, moulds and endemic organisms, can be significant causes of morbidity and mortality in…”
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Crystal Structure of the New Investigational Drug Candidate VT-1598 in Complex with Aspergillus fumigatus Sterol 14α-Demethylase Provides Insights into Its Broad-Spectrum Antifungal Activity by Hargrove, Tatiana Y, Garvey, Edward P, Hoekstra, William J, Yates, Christopher M, Wawrzak, Zdzislaw, Rachakonda, Girish, Villalta, Fernando, Lepesheva, Galina I

“…Within the past few decades, the incidence and complexity of human fungal infections have increased, and therefore, the need for safer and more efficient,…”
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Characterisation of treated effluent from four commonly employed wastewater treatment facilities: A UK case study by Yates, Christopher A., Johnes, Penny J., Spencer, Robert G.M.

“…Sewage treatment systems are a common feature across the landscape of the United Kingdom, serving an estimated 96% of the population and discharging…”
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Assessing the drivers of dissolved organic matter export from two contrasting lowland catchments, U.K by Yates, Christopher A., Johnes, Penny J., Spencer, Robert G.M.

“…Two lowland catchments in the U.K. were sampled throughout 2010–11 to investigate the dominant controls on dissolved organic matter quantity and composition…”
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Microbial uptake kinetics of dissolved organic carbon (DOC) compound groups from river water and sediments by Brailsford, Francesca L., Glanville, Helen C., Golyshin, Peter N., Johnes, Penny J., Yates, Christopher A., Jones, Davey L.

“…Dissolved organic matter (DOM) represents a key component of carbon (C) cycling in freshwater ecosystems. While the behaviour of bulk dissolved organic carbon…”
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The Fungal Cyp51-Specific Inhibitor VT-1598 Demonstrates In Vitro and In Vivo Activity against Candida auris by Wiederhold, Nathan P, Lockhart, Shawn R, Najvar, Laura K, Berkow, Elizabeth L, Jaramillo, Rosie, Olivo, Marcos, Garvey, Edward P, Yates, Christopher M, Schotzinger, Robert J, Catano, Gabriel, Patterson, Thomas F

“…is an emerging pathogen associated with significant mortality and often multidrug resistance. VT-1598, a tetrazole-based fungal CYP51-specific inhibitor, was…”
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Factors controlling the net ecosystem production of cryoconite on Western Himalayan glaciers by Shamurailatpam, Monica S., Telling, Jon, Wadham, Jemma L., Ramanathan, A. L., Yates, Christopher A., Raju, N. Janardhana

“…In situ experiments were conducted to determine the net ecosystem production (NEP) in cryoconite holes from the surface of two glaciers (Patsio glacier and…”
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179-LB: Should We Screen with a Fasting Blood Glucose Test? A Novel Two-Step Screening Strategy for Gestational Diabetes—A Large Tertiary Comparative Cohort Study by DEITCH, JESSICA, LEE, I-LYNN, YATES, CHRISTOPHER J., KATHPAL, ESHA, LAWTON, PAUL, SHAHID, IBRAHIM, STEELE, CHERYL, HAMBLIN, PETER S., KRISHNAMURTHY, BALASUBRAMANIAN, SAID, JOANNE M., TEALE, GLYN R., KEVAT, DEV

“…Background: Gestational diabetes mellitus (GDM) diagnosis is resource intensive and controversial. A modified COVID-19 GDM diagnostic method was introduced at…”
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Screening for New-Onset Diabetes After Kidney Transplantation: Limitations of Fasting Glucose and Advantages of Afternoon Glucose and Glycated Hemoglobin by Yates, Christopher J, Fourlanos, Spiros, Colman, Peter G, Cohney, Solomon J

“…BACKGROUNDThe sensitivity of fasting plasma glucose (FPG) in screening for new-onset diabetes after transplantation (NODAT) has been questioned, particularly…”
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The Role of 68Ga-DOTA-Octreotate PET/CT in Follow-Up of SDH-Associated Pheochromocytoma and Paraganglioma by Kong, Grace, Schenberg, Tess, Yates, Christopher J, Trainer, Alison, Sachithanandan, Nirupa, Iravani, Amir, Ravi Kumar, Aravind, Hofman, Michael S, Akhurst, Tim, Michael, Michael, Hicks, Rodney J

“…Abstract Purpose Germline succinate dehydrogenase (SDHx) mutation carriers, especially SDHB, are at increased risk for malignancy and require life-long…”
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Increased Prevalence of Germline Pathogenic CHEK2 Variants in Individuals With Pituitary Adenomas by De Sousa, Sunita M C, McCormack, Ann, Orsmond, Andreas, Shen, Angeline, Yates, Christopher J, Clifton-Bligh, Roderick, Santoreneos, Stephen, King, James, Feng, Jinghua, Toubia, John, Torpy, David J, Scott, Hamish S

“…Abstract Context CHEK2 is a cell cycle checkpoint regulator gene with a long-established role as a clinically relevant, moderate risk breast cancer…”
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