Positioning accuracy and daily dose assessment for prostate cancer treatment using in‐room CT image guidance at a proton therapy facility

Purpose To evaluate the effectiveness of CT image‐guided proton radiotherapy for prostate cancer by analyzing the positioning uncertainty and assessing daily dose change due to anatomical variations. Materials and methods Patients with prostate cancer were treated by opposed lateral proton beams bas...

Full description

Saved in:

Bibliographic Details
Published in:	Medical physics (Lancaster) Vol. 45; no. 5; pp. 1832 - 1843
Main Authors:	Maeda, Yoshikazu, Sato, Yoshitaka, Minami, Hiroki, Yasukawa, Yutaka, Yamamoto, Kazutaka, Tamamura, Hiroyasu, Shibata, Satoshi, Bou, Sayuri, Sasaki, Makoto, Tameshige, Yuji, Kume, Kyo, Ooto, Hiroshi, Kasahara, Shigeru, Shimizu, Yasuhiro, Saga, Yusuke, Omoya, Akira, Saitou, Makoto
Format:	Journal Article
Language:	English
Published:	United States 01-05-2018
Subjects:	Humans image‐guided radiotherapy interfractional movement in‐room CT lateral beam configuration Male Patient Positioning - methods prostate cancer Prostatic Neoplasms - diagnostic imaging Prostatic Neoplasms - radiotherapy proton range proton therapy Proton Therapy - instrumentation Radiation Dosage Radiotherapy Dosage Radiotherapy Planning, Computer-Assisted Radiotherapy, Image-Guided - instrumentation Tomography, X-Ray Computed prostate cancer proton therapy in-room CT interfractional movement proton range lateral beam configuration image-guided radiotherapy
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Purpose To evaluate the effectiveness of CT image‐guided proton radiotherapy for prostate cancer by analyzing the positioning uncertainty and assessing daily dose change due to anatomical variations. Materials and methods Patients with prostate cancer were treated by opposed lateral proton beams based on a passive scattering method using an in‐room CT image‐guided system. The system employs a single couch for both CT scanning and beam delivery. The patient was positioned by matching the boundary between the prostate and the rectum's anterior region identified in the CT images to the corresponding boundary in the simulator images after bone matching. We acquired orthogonal kV x‐ray images after couch movement and confirmed the body position by referring to the bony structure prior to treatment. In offline analyses, we contoured the targeted anatomical structures on 375 sets of daily in‐room CT images for 10 patients. The uncertainty of the image‐matching procedure was evaluated using the prostate contours and actual couch corrections. We also performed dose calculations using the same set of CT images, and evaluated daily change of dose–volume histograms (DVHs) to compare the effectiveness of the treatment using prostate matching to the bone‐matching procedure. Results The isocenter shifts by prostate matching after bone matching were 0.5 ± 1.8 and −0.8 ± 2.6 mm along the superior–inferior (SI) and anterior–posterior (AP) directions, respectively. The body movement errors (σ) after couch movement were 0.7, 0.5, and 0.3 mm along the lateral, SI and AP direction, respectively, for 30 patients. The estimated errors (σ) in the prostate matching were 1.0 and 1.3 mm, and, in conjunction with the movement errors, the total positioning uncertainty was estimated to be 1.0 and 1.4 mm along the SI and AP directions, respectively. Daily DVH analyses showed that in the prostate matching, 98.7% and 86.1% of the total 375 irradiations maintained a dose condition of V95% > 95% for the prostate and a dose constraint of V77% < 18% for the rectum, whereas 90.4% and 66.1% of the total irradiations did so when bone matching was used. The dose constraint of the rectum and dose coverage of the prostate were better maintained by prostate matching than bone matching (P < 0.001). The daily variation in the dose to the seminal vesicles (SVs) was large, and only 40% of the total irradiations maintained the initial planned values of V95% for high‐risk treatment. Nevertheless, the deviations from the original value were −4 ± 7% and −5 ± 11% in the prostate and bone matching, respectively, and a better dose coverage of the SV was achieved by the prostate matching. Conclusion The correction of repositioning along the AP and SI direction from conventional bone matching in CT image‐guided proton therapy was found to be effective to maintain the dose constraint of the rectum and the dose coverage of the prostate. This work indicated that prostate cancer treatment by prostate matching using CT image guidance may be effective to reduce the rectal complications and achieve better tumor control of the prostate. However, an adaptive approach is desirable to maintain better dose coverage of the SVs.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0094-2405 2473-4209
DOI:	10.1002/mp.12858