Search Results - "Yasui, Hiroyuki"

Analysis of the predictive factors for a critical illness of COVID-19 during treatment － relationship between serum zinc level and critical illness of COVID-19 by Yasui, Yukako, Yasui, Hiroyuki, Suzuki, Kumiko, Saitou, Takako, Yamamoto, Yoshiki, Ishizaka, Toshihiko, Nishida, Kouji, Yoshihara, Shingo, Gohma, Iwao, Ogawa, Yoshihiko

“…•A close relationship is found between low serum zinc and severe states of COVID-19.•Hypozincemia critically contributes to the aggravation of COVID-19.•Serum…”
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Current state for the development of metallopharmaceutics and anti-diabetic metal complexes by Sakurai, Hiromu, Yoshikawa, Yutaka, Yasui, Hiroyuki

“…This tutorial review introduces the current state of metallopharmaceutics development by focusing on the topics of anti-diabetic vanadium and zinc complexes…”
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Reaction and Scavenging Mechanism of β-Carotene and Zeaxanthin with Reactive Oxygen Species by Nishino, Azusa, Yasui, Hiroyuki, Maoka, Takashi

“…In order to investigate chemical scavenging mechanism of singlet oxygen, superoxide anion radical, and hydroxyl radical by carotenoids, reaction products…”
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Zinc complexes developed as metallopharmaceutics for treating diabetes mellitus based on the bio-medicinal inorganic chemistry by Yoshikawa, Yutaka, Yasui, Hiroyuki

“…Biological trace metals such as iron, zinc, copper, and manganese are essential to life and health of humans, and the success of platinum drugs in the cancer…”
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Diameter and rigidity of multiwalled carbon nanotubes are critical factors in mesothelial injury and carcinogenesis by Nagai, Hirotaka, Okazaki, Yasumasa, Chew, Shan Hwu, Misawa, Nobuaki, Yamashita, Yoriko, Akatsuka, Shinya, Ishihara, Toshikazu, Yamashita, Kyoko, Yoshikawa, Yutaka, Yasui, Hiroyuki, Jiang, Li, Ohara, Hiroki, Takahashi, Takashi, Ichihara, Gaku, Kostarelos, Kostas, Miyata, Yasumitsu, Shinohara, Hisanori, Toyokuni, Shinya

“…Multiwalled carbon nanotubes (MWCNTs) have the potential for widespread applications in engineering and materials science. However, because of their…”
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Anti-Diabetic Effect of Organo-Chalcogen (Sulfur and Selenium) Zinc Complexes with Hydroxy-Pyrone Derivatives on Leptin-Deficient Type 2 Diabetes Model ob/ob Mice by Nishiguchi, Takayuki, Yoshikawa, Yutaka, Yasui, Hiroyuki

“…Since the discovery of the anti-diabetic effects of zinc (Zn) complex, we synthesized several Zn complexes and evaluated their effects using the KKA type 2…”
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Sophisticated expression responses of ZNT1 and MT in response to changes in the expression of ZIPs by Nagamatsu, Shino, Nishito, Yukina, Yuasa, Hana, Yamamoto, Nao, Komori, Taiki, Suzuki, Takuya, Yasui, Hiroyuki, Kambe, Taiho

“…The zinc homeostatic proteins Zn transporter 1 (ZNT1) and metallothionein (MT) function in dampening increases in cytosolic zinc concentrations. Conversely,…”
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Contrasting intra- and extracellular distribution of catalytic ferrous iron in ovalbumin-induced peritonitis by Ito, Fumiya, Nishiyama, Takahiro, Shi, Lei, Mori, Masahiko, Hirayama, Tasuku, Nagasawa, Hideko, Yasui, Hiroyuki, Toyokuni, Shinya

“…Iron is an essential nutrient for every type of life on earth. However, excess iron is cytotoxic and can lead to an increased cancer risk in humans. Catalytic…”
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Preventive Effects of β-Cryptoxanthin, a Potent Antioxidant and Provitamin A Carotenoid, on Lifestyle-Related Diseases-A Central Focus on Its Effects on Non-Alcoholic Fatty Liver Disease (NAFLD) by Nishino, Azusa, Maoka, Takashi, Yasui, Hiroyuki

“…Humans usually get dietary carotenoids from foods such as green and yellow vegetables and algae. Carotenoids have been reported to effectively reduce the risk…”
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Copper accumulation in the brain causes the elevation of oxidative stress and less anxious behavior in Ts1Cje mice, a model of Down syndrome by Ishihara, Keiichi, Kawashita, Eri, Shimizu, Ryohei, Nagasawa, Kazuki, Yasui, Hiroyuki, Sago, Haruhiko, Yamakawa, Kazuhiro, Akiba, Satoshi

“…Elevated oxidative stress (OS) is widely accepted to be involved in the pathogenesis of Down syndrome (DS). However, the mechanisms underlying the elevation of…”
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Effects of Neutralizing Antibody Production on AAV-PHP.B-Mediated Transduction of the Mouse Central Nervous System by Shinohara, Yoichiro, Konno, Ayumu, Nitta, Keisuke, Matsuzaki, Yasunori, Yasui, Hiroyuki, Suwa, Junya, Hiromura, Keiju, Hirai, Hirokazu

“…Adeno-associated virus (AAV)-PHP.B, a capsid variant of AAV serotype 9, is highly permeable to the blood-brain barrier. A major obstacle to the systemic use of…”
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In Vivo Effect of Bis(Maltolato)Zinc(II) Complex on Akt Phosphorylation in Adipose Tissues of Mice by Naito, Yuki, Yamamoto, Hiroaki, Yoshikawa, Yutaka, Yasui, Hiroyuki

“…The risk of serious complication gradually increases as diabetes mellitus (DM) progresses. Thus, strategies for the prevention and delay of symptom progression…”
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Synthesis of 18F-labeled streptozotocin derivatives and an in-vivo kinetics study using positron emission tomography by Arimitsu, Kenji, Yagi, Yusuke, Koshino, Kazuhiro, Nishito, Yukina, Higuchi, Takahiro, Yasui, Hiroyuki, Kimura, Hiroyuki

“…[Display omitted] Glucose transporter 2 (GLUT2) is involved in glucose uptake by hepatocytes, pancreatic beta cells, and absorptive cells in the intestine and…”
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Syntheses of Cu(II), Ni(II), and Zn(II) complexes with 2-acetylpyrazine N(4)-phenylthiosemicarbazone and evaluation of their antidiabetic effects by Tanaka, Chihiro, Naito, Yuki, Yoshikawa, Yutaka, Yasui, Hiroyuki

“…The increasing number of patients with diabetes has recently become a serious problem following changes in diet and lifestyle. Various drugs are used to treat…”
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Exercise Performance Upregulatory Effect of R-α-Lipoic Acid with γ-Cyclodextrin by Hashimoto, Yuki, Yoshizawa, Katsuhiko, Kaido, Yuka, Takenouchi, Akiko, Terao, Keiji, Yasui, Hiroyuki, Yoshikawa, Yutaka

“…α-Lipoic acid (ALA) is a vitamin-like substance that is an indispensable supporting factor for a large number of enzymes. Due to its optical activity, ALA has…”
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Fluorobis(phenylsulfonyl)methane: A Fluoromethide Equivalent and Palladium-Catalyzed Enantioselective Allylic Monofluoromethylation by Fukuzumi, Takeo, Shibata, Norio, Sugiura, Masayoshi, Yasui, Hiroyuki, Nakamura, Shuichi, Toru, Takeshi

“…Selective introduction of fluorine: Monofluoromethylation with the fluoromethide equivalent fluorobis(phenylsulfonyl)methane (1) was crucial in the syntheses…”
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Copper-mediated radioiodination and radiobromination via aryl boronic precursor and its application to 125I/77Br–labeled prostate-specific membrane antigen imaging probes by Kondo, Yuto, Kimura, Hiroyuki, Sasaki, Ichiro, Watanabe, Shigeki, Ohshima, Yasuhiro, Yagi, Yusuke, Hattori, Yasunao, Koda, Manami, Kawashima, Hidekazu, Yasui, Hiroyuki, Ishioka, Noriko S.

“…[Display omitted] Prostate-specific membrane antigen (PSMA), expressed in prostate cancer cells, is being investigated extensively worldwide as a target for…”
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Copper‐mediated radioiodination reaction through aryl boronic acid or ester precursor and its application to direct radiolabeling of a cyclic peptide by Kondo, Yuto, Kimura, Hiroyuki, Fukumoto, Chiaki, Yagi, Yusuke, Hattori, Yasunao, Kawashima, Hidekazu, Yasui, Hiroyuki

“…A copper‐mediated radioiodination using aryl boronic precursors is attracting attention as a solution to oxidative iododestannylation and nickel‐mediated…”
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Bis(hinokitiolato)zinc complex ([Zn(hkt)2]) activates Akt/protein kinase B independent of insulin signal transduction by Naito, Yuki, Yoshikawa, Yutaka, Masuda, Kazufumi, Yasui, Hiroyuki

“…Since many Zn complexes have been developed to enhance the insulin-like activity and increase the exposure and residence of Zn in the animal body, these…”
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CF Bond Activation of Unactivated Aliphatic Fluorides: Synthesis of Fluoromethyl-3,5-diaryl-2-oxazolidinones by Desymmetrization of 2-Aryl-1,3-difluoropropan-2-ols by Haufe, Günter, Suzuki, Satoru, Yasui, Hiroyuki, Terada, Chisato, Kitayama, Takashi, Shiro, Motoo, Shibata, Norio

“…How to lose fluorine: Biologically relevant oxazolidinones 1 were synthesized through the desymmetrization of unactivated aliphatic difluorides by Si‐induced…”
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