Search Results - "Yasuhiko Shinguh"

Release of neutrophil elastase and its role in tissue injury in acute inflammation: effect of the elastase inhibitor, FR134043 by Fujie, Keiko, Shinguh, Yasuhiko, Inamura, Noriaki, Yasumitsu, Ritsuko, Okamoto, Masanori, Okuhara, Masakuni

“…Neutrophil elastase degrades extracellular matrix components and is involved in tissue destruction in several inflammatory states. We examined the inhibition…”
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FR901277, a novel inhibitor of human leukocyte elastase from Streptomyces resistomycificus. Producing organism, fermentation, isolation, physico-chemical and biological properties by Fujie, K, Shinguh, Y, Hatanaka, H, Shigematsu, N, Murai, H, Fujita, T, Yamashita, M, Okamoto, M, Okuhara, M

“…A novel human leukocyte elastase inhibitor, FR901277 was discovered in the fermentation broth of Streptomyces resistomycificus No. 7622. FR901277 has a…”
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Pharmacological evaluation of FK706, a novel and potent elastase inhibitor by Yamazaki, Akiko, Shinguh, Yasuhiko, Inamura, Noriaki, Nakahara, Kunio, Shirnomura, Kyoujchi, Ono, Takaharu

“…We found a novel and potent elastase inhibitor, FK706, sodium…”
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High Throughput Screening in the Japanese Pharmaceutical Industry by Yasuhiko Shinguh

“…During the past 5 years, Japanese pharmaceutical companies have introduced high throughput screening (HTS) into their laboratories as a major tool for the…”
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Biochemical and pharmacological characterization of FK706, a novel elastase inhibitor by Shinguh, Yasuhiko, Imai, Keisuke, Yamazaki, Akiko, Inamura, Noriaki, Shima, Ichiro, Wakabayashi, Akiko, Higashi, Yasuyuki, Ono, Takaharu

“…FK706, sodium 2-[4-[[( S)-1-[[( S)-2-[[( RS)-3, 3, 3-trifluoro-1-isopropyl-2-oxopropyl]aminocarbonyl]pyrrolidin-1-yl]carbonyl]-2-methylpropyl] aminocarbonyl]…”
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Biochemical and pharmacological characterization of FR134043, a novel elastase inhibitor by Shinguh, Yasuhiko, Yamazaki, Akiko, Inamura, Noriaki, Fujie, Keiko, Okamoto, Masanori, Nakahara, Kunio, Notsu, Yoshitada, Okuhara, Masakuni, Ono, Takaharu

“…FR134043, disodium( Z,1 S,15 S,18 S,24 S,27 R,29 S,34 S,37…”
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Pharmacological properties of a novel and potent elastase inhibitor FR 134043 by Yasuhiko Shinguh, Akiko Yamazaki, Noriaki Inamura, Kunio Nakahara, Yoshitada Notsu, Masanori Okamoto, Masakuni Okuhara, Keiji Henmi, Hirokazu Tanaka, Takaharu Ono

“…FR134043 (FR), a water soluble derivative of FR901277 isolated from the culture filtrate of streptomyces resistomicificus, is a very potent and competitive…”
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FR901451, a novel inhibitor of human leukocyte elastase from Flexibacter sp. II. Pharmacological effect of FR901451 by Fujita, T, Shinguh, Y, Yamazaki, A, Nakahara, K, Okamoto, M, Okuhara, M

“…Intratracheal (i.t.) or intravenous (i.v.) administration of FR901451, a potent inhibitor of human leukocyte elastase (HLE) prevented HLE-induced lung…”
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Erratum by Yamazaki, Akiko, Shinguh, Yasuhiko, Inamura, Noriaki

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O-222 - Pharmacological properties of a novel and potent elastase inhibitor, FR134043 by Shinguh, Yasuhiko, Yamazaki, Akiko, Inamura, Noriaki, Nakahara, Kunio, Notsu, Yoshitada, Okamoto, Masanori, Okuhara, Masakuni, Henmi, Keiji, Tanaka, Hirokazu, Ono, Takaharu

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Pharmacological properties of a novel and potent elastase inhibitor, FR134043 by Shinguh, Yasuhiko, Yamazaki, Akiko, Inamura, Noriaki, Nakahara, Kunio, Notsu, Yoshitada, Okamoto, Masanori, Okuhara, Masakuni, Henmi, Keiji, Tanaka, Hirokazu, Ono, Takaharu

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