Search Results - "Yasuhara, Hidenori"

Evaluation of off‐target effects of gapmer antisense oligonucleotides using human cells by Yoshida, Tokuyuki, Naito, Yuki, Yasuhara, Hidenori, Sasaki, Kiyomi, Kawaji, Hideya, Kawai, Jun, Naito, Mikihiko, Okuda, Haruhiro, Obika, Satoshi, Inoue, Takao

“…Antisense oligonucleotide (ASO) has the potential to induce off‐target effects due to complementary binding between the ASO and unintended RNA with a sequence…”
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Reduction of Off-Target Effects of Gapmer Antisense Oligonucleotides by Oligonucleotide Extension by Yasuhara, Hidenori, Yoshida, Tokuyuki, Sasaki, Kiyomi, Obika, Satoshi, Inoue, Takao

“…Aim Antisense oligonucleotide (ASO) has the potential to induce off-target effects by inadvertent binding of ASOs to unintended RNAs that have a sequence…”
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DNA/RNA heteroduplex oligonucleotide for highly efficient gene silencing by Nishina, Kazutaka, Piao, Wenying, Yoshida-Tanaka, Kie, Sujino, Yumiko, Nishina, Tomoko, Yamamoto, Tsuyoshi, Nitta, Keiko, Yoshioka, Kotaro, Kuwahara, Hiroya, Yasuhara, Hidenori, Baba, Takeshi, Ono, Fumiko, Miyata, Kanjiro, Miyake, Koichi, Seth, Punit P., Low, Audrey, Yoshida, Masayuki, Bennett, C. Frank, Kataoka, Kazunori, Mizusawa, Hidehiro, Obika, Satoshi, Yokota, Takanori

“…Antisense oligonucleotides (ASOs) are recognized therapeutic agents for the modulation of specific genes at the post-transcriptional level. Similar to any…”
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Evaluation of the effects of chemically different linkers on hepatic accumulations, cell tropism and gene silencing ability of cholesterol-conjugated antisense oligonucleotides by Wada, Shunsuke, Yasuhara, Hidenori, Wada, Fumito, Sawamura, Motoki, Waki, Reiko, Yamamoto, Tsuyoshi, Harada-Shiba, Mariko, Obika, Satoshi

“…Cholesterol conjugation of oligonucleotides is an attractive way to deliver the oligonucleotides specifically to the liver. However cholesterol-conjugated…”
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Prediction of human pharmacokinetics for low‐clearance compounds using pharmacokinetic data from chimeric mice with humanized livers by Yoshida, Kosuke, Doi, Yuki, Iwazaki, Norihiko, Yasuhara, Hidenori, Ikenaga, Yuka, Shimizu, Hidetoshi, Nakada, Tomohisa, Watanabe, Tomoko, Tateno, Chise, Sanoh, Seigo, Kotake, Yaichiro

“…Development of low‐clearance (CL) compounds that are slowly metabolized is a major goal in the pharmaceutical industry. However, the pursuit of low intrinsic…”
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Locked nucleic acid antisense inhibitor targeting apolipoprotein C-III efficiently and preferentially removes triglyceride from large very low-density lipoprotein particles in murine plasma by Yamamoto, Tsuyoshi, Obika, Satoshi, Nakatani, Moeka, Yasuhara, Hidenori, Wada, Fumito, Shibata, Eiko, Shibata, Masa-Aki, Harada-Shiba, Mariko

“…A 20-mer phosphorothioate antisense oligodeoxyribonucleotide having locked nucleic acids (LNA–AON) was used to reduce elevated serum triglyceride levels in…”
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Evaluation of multiple-turnover capability of locked nucleic acid antisense oligonucleotides in cell-free RNase H-mediated antisense reaction and in mice by Yamamoto, Tsuyoshi, Fujii, Naoko, Yasuhara, Hidenori, Wada, Shunsuke, Wada, Fumito, Shigesada, Naoya, Harada-Shiba, Mariko, Obika, Satoshi

“…The multiple-turnover ability of a series of locked nucleic acid (LNA)-based antisense oligonucleotides (AONs) in the RNase H-mediated scission reaction was…”
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Cholesterol-lowering Action of BNA-based Antisense Oligonucleotides Targeting PCSK9 in Atherogenic Diet-induced Hypercholesterolemic Mice by Yamamoto, Tsuyoshi, Harada-Shiba, Mariko, Nakatani, Moeka, Wada, Shunsuke, Yasuhara, Hidenori, Narukawa, Keisuke, Sasaki, Kiyomi, Shibata, Masa-Aki, Torigoe, Hidetaka, Yamaoka, Tetsuji, Imanishi, Takeshi, Obika, Satoshi

“…Recent findings in molecular biology implicate the involvement of proprotein convertase subtilisin/kexin type 9 (PCSK9) in low-density lipoprotein receptor…”
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Superior Silencing by 2',4'-BNA^(NC)-Based Short Antisense Oligonucleotides Compared to 2',4'-BNA/LNA-Based Apolipoprotein B Antisense Inhibitors by Yamamoto, Tsuyoshi, Yasuhara, Hidenori, Wada, Fumito, Harada-Shiba, Mariko, Imanishi, Takeshi, Obika, Satoshi

“…The duplex stability with target mRNA and the gene silencing potential of a novel bridged nucleic acid analogue are described. The analogue, 2',4'-BNA(NC)…”
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Superior Silencing by 2′,4′-BNANC-Based Short Antisense Oligonucleotides Compared to 2′,4′-BNA/LNA-Based Apolipoprotein B Antisense Inhibitors by Yasuhara, Hidenori, Yamamoto, Tsuyoshi, Wada, Fumito, Harada-Shiba, Mariko, Imanishi, Takeshi, Obika, Satoshi

“…The duplex stability with target mRNA and the gene silencing potential of a novel bridged nucleic acid analogue are described. The analogue, 2′,4′-BNANC…”
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Metabolomic profiling of urine-derived extracellular vesicles from rat model of drug-induced acute kidney injury by Saito, Masayoshi, Horie, Satoshi, Yasuhara, Hidenori, Kashimura, Akane, Sugiyama, Eiji, Saijo, Takeaki, Mizuno, Hajime, Kitajima, Hiroshi, Todoroki, Kenichiro

“…Extracellular vesicles (EVs) are lipid bilayer particles that are released by various cells and provide a real-time snapshot of the state of these cells in…”
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Amido-bridged nucleic acids with small hydrophobic residues enhance hepatic tropism of antisense oligonucleotides in vivo by Yamamoto, Tsuyoshi, Yahara, Aiko, Waki, Reiko, Yasuhara, Hidenori, Wada, Fumito, Harada-Shiba, Mariko, Obika, Satoshi

“…High scalability of a novel bicyclic nucleoside building block, amido-bridged nucleic acid (AmNA), to diversify pharmacokinetic properties of therapeutic…”
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Altered Biodistribution and Hepatic Safety Profile of a Gapmer Antisense Oligonucleotide Bearing Guanidine-Bridged Nucleic Acids by Sasaki, Takashi, Hirakawa, Yoko, Yamairi, Fumiko, Kurita, Takashi, Murahashi, Karin, Nishimura, Hirokazu, Iwazaki, Norihiko, Yasuhara, Hidenori, Tateoka, Takashi, Ohta, Tetsuya, Obika, Satoshi, Kotera, Jun

“…Guanidine-bridged nucleic acid (GuNA) is a novel 2',4'-bridged nucleic acid/locked nucleic acid (2',4'-BNA/LNA) analog containing cations that exhibit strong…”
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Superior silencing by 2,4-[BNA.sup.NC]-based short antisense oligonucleotides compared to 2',4'-BNA/LNA-based apolipoprotein B antisense inhibitors by Yamamoto, Tsuyoshi, Yasuhara, Hidenori, Wada, Fumito, Harada-Shiba, Mariko, Imanishi, Takeshi, Obika, Satoshi

“…The duplex stability with target mRNA and the gene silencing potential of a novel bridged nucleic acid analogue are described. The analogue, 2',4'-[BNA.sup.NC]…”
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Superior Silencing by 2′,4′-BNA NC -Based Short Antisense Oligonucleotides Compared to 2′,4′-BNA/LNA-Based Apolipoprotein B Antisense Inhibitors by Yamamoto, Tsuyoshi, Yasuhara, Hidenori, Wada, Fumito, Harada-Shiba, Mariko, Imanishi, Takeshi, Obika, Satoshi

“…The duplex stability with target mRNA and the gene silencing potential of a novel bridged nucleic acid analogue are described. The analogue, 2 ′ , 4 ′ - BNA NC…”
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