Search Results - "Yasufumi Kataoka"

Paracellular Barrier and Tight Junction Protein Expression in the Immortalized Brain Endothelial Cell Lines bEND.3, bEND.5 and Mouse Brain Endothelial Cell 4 by Watanabe, Takuya, Dohgu, Shinya, Takata, Fuyuko, Nishioku, Tsuyoshi, Nakashima, Akio, Futagami, Koujiro, Yamauchi, Atsushi, Kataoka, Yasufumi

“…The blood-brain barrier (BBB) is formed by brain endothelial cells. Many immortalized brain endothelial cell lines have been established; these have been used…”
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Brain-transportable dipeptides across the blood-brain barrier in mice by Tanaka, Mitsuru, Dohgu, Shinya, Komabayashi, Genki, Kiyohara, Hayato, Takata, Fuyuko, Kataoka, Yasufumi, Nirasawa, Takashi, Maebuchi, Motohiro, Matsui, Toshiro

“…Apart from nutrients required for the brain, there has been no report that naturally occurring peptides can cross the blood-brain barrier (BBB). The aim of…”
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Aging decreases docosahexaenoic acid transport across the blood-brain barrier in C57BL/6J mice by Iwao, Takuro, Takata, Fuyuko, Matsumoto, Junichi, Aridome, Hisataka, Yasunaga, Miho, Yokoya, Miki, Kataoka, Yasufumi, Dohgu, Shinya

“…Nutrients are actively taken up by the brain via various transporters at the blood-brain barrier (BBB). A lack of specific nutrients in the aged brain,…”
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Hesperidin blocks varenicline-aggravated atherosclerotic plaque formation in apolipoprotein E knockout mice by downregulating net uptake of oxidized low-density lipoprotein in macrophages by Koga, Mitsuhisa, Kanaoka, Yuki, Inada, Koshun, Omine, Sai, Kataoka, Yasufumi, Yamauchi, Atsushi

“…Varenicline is a widely used and effective drug for smoking cessation. We have previously reported experimental evidence suggesting that varenicline increases…”
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Tumor Necrosis Factor-α Mediates the Blood–Brain Barrier Dysfunction Induced by Activated Microglia in Mouse Brain Microvascular Endothelial Cells by Nishioku, Tsuyoshi, Matsumoto, Junichi, Dohgu, Shinya, Sumi, Noriko, Miyao, Kenji, Takata, Fuyuko, Shuto, Hideki, Yamauchi, Atsushi, Kataoka, Yasufumi

“…The present study was designed to elucidate the involvement of tumor necrosis factor-α (TNF-α) release from activated microglia in the induction of blood–brain…”
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Brain pericytes are the most thrombin-sensitive matrix metalloproteinase-9-releasing cell type constituting the blood–brain barrier in vitro by Machida, Takashi, Takata, Fuyuko, Matsumoto, Junichi, Takenoshita, Hisayo, Kimura, Ikuya, Yamauchi, Atsushi, Dohgu, Shinya, Kataoka, Yasufumi

“…•Thrombin induced MMP-9 release from brain pericytes.•This MMP-9 release from pericytes was higher than that from other BBB cells.•Pericytes expressed high and…”
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Reactive pericytes in early phase are involved in glial activation and late-onset hypersusceptibility to pilocarpine-induced seizures in traumatic brain injury model mice by Sakai, Kenta, Takata, Fuyuko, Yamanaka, Gaku, Yasunaga, Miho, Hashiguchi, Kana, Tominaga, Kazuki, Itoh, Kouichi, Kataoka, Yasufumi, Yamauchi, Atsushi, Dohgu, Shinya

“…In this study, among neurovascular unit (NVU) cells, we focused on pericyte reactivity in mice subjected to controlled cortical impact (CCI) to understand how…”
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Contribution of thrombin-reactive brain pericytes to blood-brain barrier dysfunction in an in vivo mouse model of obesity-associated diabetes and an in vitro rat model by Machida, Takashi, Takata, Fuyuko, Matsumoto, Junichi, Miyamura, Tomoyuki, Hirata, Ryosuke, Kimura, Ikuya, Kataoka, Yasufumi, Dohgu, Shinya, Yamauchi, Atsushi

“…Diabetic complications are characterized by the dysfunction of pericytes located around microvascular endothelial cells. The blood-brain barrier (BBB) exhibits…”
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Oncostatin M–induced blood‐brain barrier impairment is due to prolonged activation of STAT3 signaling in vitro by Takata, Fuyuko, Dohgu, Shinya, Matsumoto, Junichi, Machida, Takashi, Sakaguchi, Shinya, Kimura, Ikuya, Yamauchi, Atsushi, Kataoka, Yasufumi

“…Oncostatin M (OSM) is a member of the interleukin (IL)‐6 family cytokines. We previously demonstrated that OSM induces blood‐brain barrier (BBB) impairment…”
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Metformin induces up-regulation of blood–brain barrier functions by activating AMP-activated protein kinase in rat brain microvascular endothelial cells by Takata, Fuyuko, Dohgu, Shinya, Matsumoto, Junichi, Machida, Takashi, Kaneshima, Shuji, Matsuo, Mai, Sakaguchi, Shinya, Takeshige, Yuki, Yamauchi, Atsushi, Kataoka, Yasufumi

“…•Metformin up-regulated the rat brain endothelial barrier function.•Compound C, an AMPK inhibitor, blocked the increased barrier tightness by…”
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Varenicline aggravates atherosclerotic plaque formation in nicotine-pretreated ApoE knockout mice due to enhanced oxLDL uptake by macrophages through downregulation of ABCA1 and ABCG1 expression by Koga, Mitsuhisa, Kanaoka, Yuki, Okamoto, Mana, Nakao, Yuki, Inada, Koshun, Takayama, Saki, Kataoka, Yasufumi, Yamauchi, Atsushi

“…Varenicline is a widely used and effective drug for smoking cessation. We previously reported that varenicline aggravates atherosclerosis in apolipoprotein E…”
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Oncostatin-M-Reactive Pericytes Aggravate Blood–Brain Barrier Dysfunction by Activating JAK/STAT3 Signaling In Vitro by Takata, Fuyuko, Dohgu, Shinya, Sakaguchi, Shinya, Sakai, Kenta, Yamanaka, Gaku, Iwao, Takuro, Matsumoto, Junichi, Kimura, Ikuya, Sezaki, Yume, Tanaka, Yoshie, Yamauchi, Atsushi, Kataoka, Yasufumi

“…The present findings demonstrate that (1) pericytes can respond to OSM and (2) OSM-reactive pericytes aggravate OSM-induced RBEC barrier dysfunction. These…”
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The Neuroinflammatory Role of Pericytes in Epilepsy by Yamanaka, Gaku, Takata, Fuyuko, Kataoka, Yasufumi, Kanou, Kanako, Morichi, Shinichiro, Dohgu, Shinya, Kawashima, Hisashi

“…Pericytes are a component of the blood–brain barrier (BBB) neurovascular unit, in which they play a crucial role in BBB integrity and are also implicated in…”
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Varenicline is a smoking cessation drug that blocks alveolar expansion in mice intratracheally administrated porcine pancreatic elastase by Koga, Mitsuhisa, Kanaoka, Yuki, Tashiro, Tetsushi, Hashidume, Nagisa, Kataoka, Yasufumi, Yamauchi, Atsushi

“…Smoking cessation is the most effective treatment in patients with emphysema and lung inflammation. The aim of the present study was to examine the effect of…”
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Brain pericytes among cells constituting the blood-brain barrier are highly sensitive to tumor necrosis factor-α, releasing matrix metalloproteinase-9 and migrating in vitro by Takata, Fuyuko, Dohgu, Shinya, Matsumoto, Junichi, Takahashi, Hiroyuki, Machida, Takashi, Wakigawa, Tomoya, Harada, Eriko, Miyaji, Haruki, Koga, Mitsuhisa, Nishioku, Tsuyoshi, Yamauchi, Atsushi, Kataoka, Yasufumi

“…Increased matrix metalloproteinase (MMP)-9 in the plasma and brain is associated with blood-brain barrier (BBB) disruption through proteolytic activity in…”
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Activation of the α7 nicotinic acetylcholine receptor upregulates blood-brain barrier function through increased claudin-5 and occludin expression in rat brain endothelial cells by Kimura, Ikuya, Dohgu, Shinya, Takata, Fuyuko, Matsumoto, Junichi, Kawahara, Yohei, Nishihira, Megumi, Sakada, Shohei, Saisho, Takuya, Yamauchi, Atsushi, Kataoka, Yasufumi

“…•α7 nAChR agonist tightens the brain endothelial tight junction barrier.•α7 nAChR agonist increases claudin-5 and occludin in brain endothelial…”
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Pericytes from brain microvessels strengthen the barrier integrity in primary cultures of rat brain endothelial cells by Nakagawa, Shinsuke, Deli, Mária A, Nakao, Shinobu, Honda, Masaru, Hayashi, Kentaro, Nakaoke, Ryota, Kataoka, Yasufumi, Niwa, Masami

“…(1) The blood-brain barrier (BBB) characteristics of cerebral endothelial cells are induced by organ-specific local signals. Brain endothelial cells lose their…”
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Detachment of Brain Pericytes from the Basal Lamina is Involved in Disruption of the Blood-Brain Barrier Caused by Lipopolysaccharide-Induced Sepsis in Mice by Nishioku, Tsuyoshi, Dohgu, Shinya, Takata, Fuyuko, Eto, Tomoaki, Ishikawa, Naoko, Kodama, Kota B, Nakagawa, Shinsuke, Yamauchi, Atsushi, Kataoka, Yasufumi

“…The blood-brain barrier (BBB) is highly restrictive of the transport of substances between blood and the central nervous system. Brain pericytes are one of the…”
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Permeability studies on in vitro blood-brain barrier models: physiology, pathology, and pharmacology by Deli, Máiria A, Abrahám, Csongor S, Kataoka, Yasufumi, Niwa, Masami

“…(1) The specifically regulated restrictive permeability barrier to cells and molecules is the most important feature of the blood-brain barrier (BBB). The aim…”
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Brain-transportable soy dipeptide, Tyr-Pro, attenuates amyloid β peptide25-35-induced memory impairment in mice by Tanaka, Mitsuru, Kiyohara, Hayato, Yoshino, Atsuko, Nakano, Akihiro, Takata, Fuyuko, Dohgu, Shinya, Kataoka, Yasufumi, Matsui, Toshiro

“…In this study, experiments on amyloid β peptide 25-35 -induced mice were performed to provide in vivo evidence on the potential of the blood–brain barrier…”
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