Search Results - "Yasuda, Mitsuya"

N-Methyl-N-Nitrosourea-Induced Acute Alteration of Retinal Function and Morphology in Monkeys by Kinoshita, Junzo, Iwata, Noriaki, Maejima, Takanori, Imaoka, Masako, Kimotsuki, Tomofumi, Yasuda, Mitsuya

“…The purpose of this study was to investigate both functional and morphologic alteration of the retina acutely induced by N-methyl-N-nitrosourea (MNU) in…”
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Mechanism of voriconazole-induced transient visual disturbance: reversible dysfunction of retinal ON-bipolar cells in monkeys by Kinoshita, Junzo, Iwata, Noriaki, Ohba, Mitsuhiro, Kimotsuki, Tomofumi, Yasuda, Mitsuya

“…To investigate the mechanism of voriconazole-induced transient visual disturbance in humans. andard full-field electroretinograms (ERGs) were recorded from…”
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Age-related differences of QT interval and autonomic nervous system activity in female cynomolgus monkeys by Ishizaka, Tomomichi, Yoshimatsu, Yu, Ozawa, Minori, Kimotsuki, Tomofumi, Takasaki, Wataru, Manabe, Sunao, Yasuda, Mitsuya

“…Cynomolgus monkeys are used in in vivo toxicological studies to evaluate the effects of drug candidates on the cardiovascular system, especially the effects of…”
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Detection of Drug-Induced Retinal Dysfunction by Electroretinographic Assessment of the Function in Rod- and Cone-Pathways in Cynomolgus Monkeys: Investigation by Administration of Digoxin by KINOSHITA, Junzo, KIMOTSUKI, Tomofumi, SAKURAI, Ken, YASUDA, Mitsuya

“…The purpose of this study was to examine whether the drug-induced alteration of electroretinogram (ERG) corresponding to that reported in humans could be…”
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Factors influencing intraocular pressure in cynomolgus monkeys by IWATA, Noriaki, SAKURAI, Ken, KINOSHITA, Junzo, KIMOTSUKI, Tomofumi, YASUDA, Mitsuya

“…Intraocular pressure (IOP) is widely measured for evaluating physiology, diseases and toxic changes of the eye. IOP was reported to be influenced by various…”
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Topographic analysis of flash visual evoked potentials in dogs by Kimotsuki, T.(Sankyo Co. Ltd., Fukuroi, Shizuoka (Japan). Medicinal Safety Research Labs.), Yasuda, M, Tamahara, S, Matsuki, N, Ono, K

“…Visual evoked potentials by flash stimulation (flash VEP) were analyzed in dogs using a topographic method. The flash VEP consisted of 3 positive (P1, P2 and…”
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Sildenafil-induced reversible impairment of rod and cone phototransduction in monkeys by Kinoshita, Junzo, Iwata, Noriaki, Shimoda, Hitomi, Kimotsuki, Tomofumi, Yasuda, Mitsuya

“…To investigate functional alteration of the retina induced by sildenafil in monkeys. Sildenafil was administered intravenously to cynomolgus monkeys at dose…”
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Age-associated changes of flash visual evoked potentials in dogs by Kimotsuki, T.(Sankyo Co. Ltd., Fukuroi, Shizuoka (Japan). Medicinal Safety Research Labs.), Yasuda, M, Tamahara, S, Tomihara, M, Matsuki, N, Ono, K

“…Age-associated changes of visual evoked potentials by flash stimulation (flash VEP) were evaluated in 53 beagle dogs aged from 1- to 15-year-old. Among the…”
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Retinal function and morphology in monkeys with ethambutol-induced optic neuropathy by Kinoshita, Junzo, Iwata, Noriaki, Maejima, Takanori, Kimotsuki, Tomofumi, Yasuda, Mitsuya

“…Ethambutol-induced optic neuropathy is a well recognized adverse ocular event. However, abnormalities of the retina in this optic neuropathy are not fully…”
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Digoxin-induced reversible dysfunction of the cone photoreceptors in monkeys by Kinoshita, Junzo, Iwata, Noriaki, Kimotsuki, Tomofumi, Yasuda, Mitsuya

“…To investigate functional alteration of the retina induced by digoxin in monkeys. Digoxin was intravenously administered to cynomolgus monkeys and standard…”
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カニクイザルでの網膜電図を用いた杆体経路及び錐体経路機能の評価による薬剤誘発性網膜機能障害の検出：ジゴキシン投与による検討 by 木下, 順三, 肝付, 智文, 櫻井, 健, 安田, 充也

“…本実験は、カニクイザルでの網膜電図（Electroretinogram：ERG）による杆体経路及び錐体経路機能の評価により、ヒトで報告されている薬剤誘発性のERGの変化を検出可能か調べることを目的として実施した。…”
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カニクイザルの眼圧に影響を与える因子の検討 by 岩田, 憲明, 櫻井, 健, 木下, 順三, 肝付, 智文, 安田, 充也

“…眼圧測定は、眼球の生理学的状態、疾病あるいは毒性変化の評価のために広く用いられているが、眼圧はヒト、アカゲザルおよびイヌを含む多くの種において様々な因子により影響を受けることが報告されている1-10）。本実験では、カニクイザルにおける眼圧に対する麻酔、測定体位、日内の測定時間帯および散瞳の影響について検討を行った。…”
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EFFECT OF TROGLITAZONE ON THE LIVER OF A GUNN RAT MODEL OF GENETIC ENZYME POLYMORPHISM by WATANABE, Toshiyuki, FURUKAWA, Tadashi, SHARYO, Satoru, OHASHI, Yoshihiko, YASUDA, Mitsuya, TAKAOKA, Masaya, MANABE, Sunao

“…There is a possibility that serious liver dysfunction rarely observed in diabetic patients given troglitazone is attributable to idiosyncratic abnormalities in…”
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Continuous and simultaneous monitoring of glucose and electrocardiogram in monkeys treated with quinolones by Ishizaka, Tomomichi, Yoshimatsu, Yu, Ozawa, Minori, Sakurai, Ken, Kimotsuki, Tomofumi, Sanbuissho, Atsushi, Yasuda, Mitsuya

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Sildenafil-Induced Reversible Impairment of Rod and Cone Phototransduction in Monkeys by Kinoshita, J., Iwata, N., Shimoda, H., Kimotsuki, T., Yasuda, M.

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Evaluation of drug-induced QT prolongation in a halothane-anesthetized monkey model: Effects of sotalol by Ishizaka, Tomomichi, Yoshimatsu, Yu, Ozawa, Minori, Kimotsuki, Tomofumi, Takasaki, Wataru, Manabe, Sunao, Yasuda, Mitsuya

“…Cynomolgus monkeys are used in in vivo models of safety pharmacological studies to evaluate the effects of drug candidates on the cardiovascular system. Models…”
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Changes of magnetic resonance imaging on the brain in beagle dogs with aging by Kimotsuki, T.(Sankyo Co. Ltd., Fukuroi, Shizuoka (Japan). Medicinal Safety Research Labs.), Nagaoka, T, Yasuda, M, Tamahara, S, Matsuki, N, Ono, K

“…Age-associated changes of magnetic resonance imaging (MRI) on the brain were evaluated in 19 beagle dogs aged from 8-month- to 16-year-old. A significant…”
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NERVOUS INFLUENCES UPON THE HEART DUE TO OVERDISTENSION OF THE URINARY BLADDER: THE RELATION OF ITS MECHANISM TO VAGO-VAGAL REFLEX by YAMAGUCHI, YOICHI, TSUCHIYA, MASAHARU, AKIBA, TADAYOSHI, YASUDA, MITSUYA, KIRYU, YASUYOSHI, HAGIWARA, TAKASHI, FUJISHIRO, YASUO, SUGAYA, EIICHI

“…1. In two patiens suffering from urinary retention of various causes, appearance of arrhythmias were seen at the time of overdistension of the urinary bladder,…”
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STUDIES ON ELECTROPHYSIOLOGICAL PROPERTIES OF VAGO-VAGAL REFLEX by SUGAYA, EIICHI, AKIBA, TADAYOSHI, TSUCHIYA, MASAHARU, KIRYU, YASUYOSHI, YASUDA, MITSUYA, YAMAGUCHI, YOICHI, FUJISHIRO, YASUO

“…1. Electrical reflex response of vago-vagal reflex was studied by stimulating the cervical vagus nerve of the right side and recording from the cervical vagus…”
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A case of idiopathic throbocytopenic purpura associated with hyperthyroidism (author's transl) by Muraki, H, Toyama, K, Hasegawa, M, Shimabukuro, K, Yasuda, M

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