Search Results - "Yassa, A."

Neuroimaging Biomarkers for Alzheimer's Disease by Márquez, Freddie, Yassa, Michael A

“…Currently, over five million Americans suffer with Alzheimer's disease (AD). In the absence of a cure, this number could increase to 13.8 million by 2050. A…”
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Integrating new findings and examining clinical applications of pattern separation by Leal, Stephanie L., Yassa, Michael A.

“…Pattern separation, the ability to independently represent and store similar experiences, is a crucial facet of episodic memory. Growing evidence suggests that…”
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Object and spatial mnemonic interference differentially engage lateral and medial entorhinal cortex in humans by Reagh, Zachariah M, Yassa, Michael A

“…Recent models of episodic memory propose a division of labor among medial temporal lobe cortices comprising the parahippocampal gyrus. Specifically, perirhinal…”
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Reduction of Hippocampal Hyperactivity Improves Cognition in Amnestic Mild Cognitive Impairment by Bakker, Arnold, Krauss, Gregory L., Albert, Marilyn S., Speck, Caroline L., Jones, Lauren R., Stark, Craig E., Yassa, Michael A., Bassett, Susan S., Shelton, Amy L., Gallagher, Michela

“…Elevated hippocampal activation is observed in conditions that confer risk for Alzheimer's disease, including amnestic mild cognitive impairment (aMCI)…”
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Autism: A form of lead and mercury toxicity by Yassa, Heba A

“…Highlights • Autism is a developmental disability characterized by severe, pervasive deficits in social interaction and communications. • Lead and mercury two…”
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A task to assess behavioral pattern separation (BPS) in humans: Data from healthy aging and mild cognitive impairment by Stark, Shauna M., Yassa, Michael A., Lacy, Joyce W., Stark, Craig E.L.

“…Changes in memory performance are one of the hallmark symptoms of mild cognitive impairment and are affected by healthy aging as well. Pattern separation,…”
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Pupil dynamics during very light exercise predict benefits to prefrontal cognition by Kuwamizu, Ryuta, Yamazaki, Yudai, Aoike, Naoki, Hiraga, Taichi, Hata, Toshiaki, Yassa, Michael A., Soya, Hideaki

“…•We examine the effect of very light exercise on pupil size and prefrontal function.•Very light exercise improved executive function and task-related neural…”
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Amygdala-hippocampal dynamics during salient information processing by Zheng, Jie, Anderson, Kristopher L., Leal, Stephanie L., Shestyuk, Avgusta, Gulsen, Gultekin, Mnatsakanyan, Lilit, Vadera, Sumeet, Hsu, Frank P. K., Yassa, Michael A., Knight, Robert T., Lin, Jack J.

“…Recognizing motivationally salient information is critical to guiding behaviour. The amygdala and hippocampus are thought to support this operation, but the…”
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Age-related memory deficits linked to circuit-specific disruptions in the hippocampus by Yassa, Michael A, Mattfeld, Aaron T, Stark, Shauna M, Stark, Craig E.L

“…Converging data from rodents and humans have demonstrated an age-related decline in pattern separation abilities (the ability to discriminate among similar…”
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The ANTsX ecosystem for quantitative biological and medical imaging by Tustison, Nicholas J., Cook, Philip A., Holbrook, Andrew J., Johnson, Hans J., Muschelli, John, Devenyi, Gabriel A., Duda, Jeffrey T., Das, Sandhitsu R., Cullen, Nicholas C., Gillen, Daniel L., Yassa, Michael A., Stone, James R., Gee, James C., Avants, Brian B.

“…The Advanced Normalizations Tools ecosystem, known as ANTsX, consists of multiple open-source software libraries which house top-performing algorithms used…”
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Acute moderate exercise improves mnemonic discrimination in young adults by Suwabe, Kazuya, Hyodo, Kazuki, Byun, Kyeongho, Ochi, Genta, Yassa, Michael A., Soya, Hideaki

“…ABSTRACT Increasing evidence suggests that regular moderate exercise increases neurogenesis in the dentate gyrus (DG) of the hippocampus and improves memory…”
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Pattern Separation and Source Memory Engage Distinct Hippocampal and Neocortical Regions during Retrieval by Stevenson, Rebecca F, Reagh, Zachariah M, Chun, Amanda P, Murray, Elizabeth A, Yassa, Michael A

“…Detailed representations of past events rely on the ability to form associations between items and their contextual features (i.e., source memory), as well as…”
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Pattern separation of emotional information in hippocampal dentate and CA3 by Leal, Stephanie L., Tighe, Sarah K., Jones, Craig K., Yassa, Michael A.

“…ABSTRACT Emotional arousal, mediated by the amygdala, is known to modulate episodic memories stored by the hippocampus, a region involved in pattern separation…”
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Benefit of human moderate running boosting mood and executive function coinciding with bilateral prefrontal activation by Damrongthai, Chorphaka, Kuwamizu, Ryuta, Suwabe, Kazuya, Ochi, Genta, Yamazaki, Yudai, Fukuie, Takemune, Adachi, Kazutaka, Yassa, Michael A., Churdchomjan, Worachat, Soya, Hideaki

“…Running, compared to pedaling is a whole-body locomotive movement that may confer more mental health via strongly stimulating brains, although running impacts…”
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Asymmetric effects of emotion on mnemonic interference by Leal, Stephanie L., Tighe, Sarah K., Yassa, Michael A.

“…•Discrimination of similar items impaired on emotional but not neutral items.•Emotional modulation effect magnified after 24h.•Hyper-discrimination of negative…”
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Theta mediated dynamics of human hippocampal-neocortical learning systems in memory formation and retrieval by Gattas, Sandra, Larson, Myra Sarai, Mnatsakanyan, Lilit, Sen-Gupta, Indranil, Vadera, Sumeet, Swindlehurst, A. Lee, Rapp, Paul E., Lin, Jack J., Yassa, Michael A.

“…Episodic memory arises as a function of dynamic interactions between the hippocampus and the neocortex, yet the mechanisms have remained elusive. Here, using…”
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Awake ripples enhance emotional memory encoding in the human brain by Zhang, Haoxin, Skelin, Ivan, Ma, Shiting, Paff, Michelle, Mnatsakanyan, Lilit, Yassa, Michael A., Knight, Robert T., Lin, Jack J.

“…Enhanced memory for emotional experiences is hypothesized to depend on amygdala-hippocampal interactions during memory consolidation. Here we show using…”
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Disruption of amygdala–entorhinal–hippocampal network in late‐life depression by Leal, Stephanie L., Noche, Jessica A., Murray, Elizabeth A., Yassa, Michael A.

“…ABSTRACT Episodic memory deficits are evident in late‐life depression (LLD) and are associated with subtle synaptic and neurochemical changes in the medial…”
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Overnight olfactory enrichment using an odorant diffuser improves memory and modifies the uncinate fasciculus in older adults by Woo, Cynthia C, Miranda, Blake, Sathishkumar, Mithra, Dehkordi-Vakil, Farideh, Yassa, Michael A, Leon, Michael

“…Cognitive loss in older adults is a growing issue in our society, and there is a need to develop inexpensive, simple, effective in-home treatments. This study…”
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Ultrahigh-resolution microstructural diffusion tensor imaging reveals perforant path degradation in aged humans in vivo by Yassa, Michael A., Muftuler, L. Tugan, Stark, Craig E. L., Squire, Larry R.

“…The perforant path (PP) undergoes synaptic changes in the course of aging and dementia. Previous studies attempting to assess the integrity of the PP in humans…”
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