Angiotensin-converting enzyme gene variant and its levels: risk factors for myocardial infarction in a South Indian population

Recently, there has been increasing evidence that genetic variation in the angiotensin-converting enzyme (ACE) plays an important role in myocardial infarction. Therefore, the present study was carried out with the aim of investigating the association of the ACE gene insertion/deletion (I /D) polymo...

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Bibliographic Details
Published in:	Singapore medical journal Vol. 51; no. 7; p. 576
Main Authors:	Pulla Reddy, B, Srikanth Babu, B M, Venkata Karunakar, K, Yasovanthi, J, Munshi, A, Sampath Kumar, P, Sharath, A, Jyothy, A
Format:	Journal Article
Language:	English
Published:	Singapore 01-07-2010
Subjects:	Alleles Case-Control Studies Chi-Square Distribution Confidence Intervals Ethnic Groups - genetics Female Genetic Predisposition to Disease - epidemiology Genetic Variation Genotype Humans Incidence India - epidemiology Male Myocardial Infarction - epidemiology Myocardial Infarction - genetics Myocardial Infarction - physiopathology Odds Ratio Peptidyl-Dipeptidase A - analysis Peptidyl-Dipeptidase A - genetics Polymorphism, Genetic Reference Values India
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Summary:	Recently, there has been increasing evidence that genetic variation in the angiotensin-converting enzyme (ACE) plays an important role in myocardial infarction. Therefore, the present study was carried out with the aim of investigating the association of the ACE gene insertion/deletion (I /D) polymorphism and its levels in myocardial infarction patients and their first-degree relatives (FDRs). 206 patients with myocardial infarction, 168 FDRs and 210 control subjects were enrolled in the study. ACE I /D polymorphism was determined using the polymerase chain reaction method. Serum ACE levels were measured using the photometric method. The DD genotype and ACE activity were significantly higher in patients (p-value is 0.00006 and 0.0001, respectively) and FDRs (p-value is 0.003 and 0.04, respectively) compared with the controls. ACE DD genotype and ACE levels are important risk factors for myocardial infarction. This study indicates that the higher frequency of the DD genotype and ACE levels observed in FDRs may increase susceptibility to developing myocardial infarction.
ISSN:	0037-5675